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    GCP2 gamma-tubulin complex protein 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 830445, updated on 18-Sep-2024

    Summary

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    Official Symbol
    GCP2
    Official Full Name
    gamma-tubulin complex protein 2
    Primary source
    TAIR:AT5G05620
    Locus tag
    AT5G05620
    See related
    Araport:AT5G05620
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS THALIANA GAMMA-TUBULIN COMPLEX PROTEIN 2; ARABIDOPSIS THALIANA GAMMA-TUBULIN COMPLEX PROTEIN 2; ATGCP2; gamma-tubulin complex protein 2; GAMMA-TUBULIN 2; gamma-tubulin complex protein 2; MJJ3.10; MJJ3_10; TUBG2
    Summary
    Paralog of TUBG1, required for centrosomal and noncentrosomal microtubule nucleation. Involved in specification of cell identity, such as stomatal patterning. Constitutively expressed throughout plant. Enriched at the post-cytokinetic cell edges in leaves and roots.
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    Genomic context

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    See GCP2 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    10
    Sequence:
    Chromosome: 5; NC_003076.8 (1679230..1682055)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene 2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase superfamily protein Neighboring gene alfin-like 1 Neighboring gene Amino acid permease family protein Neighboring gene uncharacterized protein Neighboring gene nucleoprotein-like protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cell edges accumulate gamma tubulin complex components and nucleate microtubules following cytokinesis in Arabidopsis thaliana. Ambrose C, et al. PLoS One, 2011. PMID 22110647, Free PMC Article
    2. Gamma-tubulin is essential for microtubule organization and development in Arabidopsis. Pastuglia M, et al. Plant Cell, 2006 Jun. PMID 16698945, Free PMC Article
    3. Gamma-tubulin is essential for acentrosomal microtubule nucleation and coordination of late mitotic events in Arabidopsis. Binarová P, et al. Plant Cell, 2006 May. PMID 16603653, Free PMC Article
    4. A mutation in the Arabidopsis gamma-tubulin-containing complex causes helical growth and abnormal microtubule branching. Nakamura M, et al. J Cell Sci, 2009 Jul 1. PMID 19509058
    5. Feeding cells induced by phytoparasitic nematodes require γ-tubulin ring complex for microtubule reorganization. Banora MY, et al. PLoS Pathog, 2011 Dec. PMID 22144887, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. gamma tubulin nucleation complex (GCP2 and GCP3) localize at distinct sites along the outer periclinal edge of newly formed crosswalls
      Title: Cell edges accumulate gamma tubulin complex components and nucleate microtubules following cytokinesis in Arabidopsis thaliana.
    2. Results show that a null mutation of Arabidopsis GCP2, a core subunit of the gamma-tubulin-containing complex, severely impaired the development of male and female gametophytes.
      Title: A mutation in the Arabidopsis gamma-tubulin-containing complex causes helical growth and abnormal microtubule branching.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_120644.3

    Gene Ontology Provided by TAIR

    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cytokinesis by cell plate formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cytoplasmic microtubule organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within embryo sac development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within leaf development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within microtubule nucleation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within microtubule polymerization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within phragmoplast assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in response to nematode IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within root hair cell tip growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within stomatal complex morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    NOT located_in cytosol RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    part_of gamma-tubulin complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plant-type cell wall HDA PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    gamma-tubulin complex protein 2
    NP_196181.1
    • gamma-tubulin complex protein 2 (GCP2); FUNCTIONS IN: structural molecule activity, GTP binding, GTPase activity; INVOLVED IN: in 9 processes; LOCATED IN: in 6 components; CONTAINS InterPro DOMAIN/s: Gamma tubulin (InterPro:IPR002454), Tubulin (InterPro:IPR000217), Tubulin/FtsZ, GTPase domain (InterPro:IPR003008), Tubulin/FtsZ, N-terminal (InterPro:IPR019746), Tubulin/FtsZ, C-terminal (InterPro:IPR008280), Tubulin, conserved site (InterPro:IPR017975), Tubulin/FtsZ, 2-layer sandwich domain (InterPro:IPR018316); BEST Arabidopsis thaliana protein match is: gamma-tubulin (TAIR:AT3G61650.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      1679230..1682055
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_120644.3 → NP_196181.1  gamma-tubulin complex protein 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_196181.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4IJ36, P38558
      UniProtKB/TrEMBL
      A0A178UJQ8, A0A5S9Y2E0, A0A7G2F8Q8
      Conserved Domains (1) summary
      PLN00222
      Location:1 → 454
      PLN00222; tubulin gamma chain; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38558.1

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