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    XPB1 DNA repair helicase XPB1-like protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 834139, updated on 18-Sep-2024

    Summary

    Official Symbol
    XPB1
    Official Full Name
    DNA repair helicase XPB1-like protein
    Primary source
    TAIR:AT5G41370
    Locus tag
    AT5G41370
    See related
    Araport:AT5G41370
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS HOMOLOG OF XERODERMA PIGMENTOSUM COMPLEMENTATION GROUP B 1; ATXPB1; homolog of xeroderma pigmentosum complementation group B 1; MYC6.8; MYC6_8
    Summary
    Encodes XPB1, a DNA repair protein and transcription factor. Arabidopsis thaliana has duplicated XPB gene (AtXPB1 and AtXPB2, with high similarity to each other). XPB proteins are involved in both DNA repair and transcription, they are component of the transcription factor IIH (TFIIH) and are responsible for DNA helicase activity during nucleotide (nt) excision repair (NER). Complementation assays in yeast rad25 mutant strains suggest the involvement of AtXPB2 in DNA repair. Although both genes are expressed in a constitutive manner during the plant life cycle, Northern blot analyses suggest that light modulates the expression level of both XPB copies.
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    Genomic context

    See XPB1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    17
    Sequence:
    Chromosome: 5; NC_003076.8 (16551119..16556038)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene RING/U-box superfamily protein Neighboring gene homolog of Xeroderma pigmentosum complementation group B 2 Neighboring gene CCT motif family protein Neighboring gene PLAC8 family protein

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    DNA repair helicase XPB1-like protein
    NP_568592.1
    • homolog of xeroderma pigmentosum complementation group B 1 (XPB1); FUNCTIONS IN: in 7 functions; INVOLVED IN: response to UV, response to toxin; LOCATED IN: nucleus, cytoplasm; EXPRESSED IN: whole plant, male gametophyte, pollen tube; EXPRESSED DURING: L mature pollen stage, M germinated pollen stage, seedling growth; CONTAINS InterPro DOMAIN/s: Restriction endonuclease, type I, R subunit/Type III, Res subunit (InterPro:IPR006935), DEAD-like helicase, N-terminal (InterPro:IPR014001), Xeroderma pigmentosum group B protein (XP-B) (InterPro:IPR001161), DNA/RNA helicase, C-terminal (InterPro:IPR001650), Helicase, superfamily 1/2, ATP-binding domain (InterPro:IPR014021); BEST Arabidopsis thaliana protein match is: homolog of Xeroderma pigmentosum complementation group B 2 (TAIR:AT5G41360.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      16551119..16556038
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_123502.3NP_568592.1  DNA repair helicase XPB1-like protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_568592.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O04171, Q38861, Q6JA92, Q9FN63
      UniProtKB/TrEMBL
      A0A178UCR1, A0A5S9Y9W4
      Conserved Domains (1) summary
      TIGR00603
      Location:51764
      rad25; DNA repair helicase rad25