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    CTR1 Protein kinase superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 831748, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CTR1
    Official Full Name
    Protein kinase superfamily protein
    Primary source
    TAIR:AT5G03730
    Locus tag
    AT5G03730
    See related
    Araport:AT5G03730
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtCTR1; CONSTITUTIVE TRIPLE RESPONSE 1; F17C15.150; F17C15_150; SERINE/THREONINE-PROTEIN KINASE CTR1; SIS1; SUGAR-INSENSITIVE 1
    Summary
    Homologous to the RAF family of serine/threonine protein kinases. Negative regulator in the ethylene signal transduction pathway. Interacts with the putative ethylene receptors ETR1 and ERS. Constitutively expressed.
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    Genomic context

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    See CTR1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    16
    Sequence:
    Chromosome: 5; NC_003076.8 (974360..979849, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene tRNA-Leu Neighboring gene replication factor C large subunit Neighboring gene heat shock transcription factor A3 Neighboring gene histone deacetylase 2C Neighboring gene tRNA-Leu

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. CTR1, a negative regulator of the ethylene response pathway in Arabidopsis, encodes a member of the raf family of protein kinases. Kieber JJ, et al. Cell, 1993 Feb 12. PMID 8431946
    2. The sugar-insensitive1 (sis1) mutant of Arabidopsis is allelic to ctr1. Gibson SI, et al. Biochem Biophys Res Commun, 2001 Jan 12. PMID 11162499
    3. Unsaturation of very-long-chain ceramides protects plant from hypoxia-induced damages by modulating ethylene signaling in Arabidopsis. Xie LJ, et al. PLoS Genet, 2015 Mar. PMID 25822663, Free PMC Article
    4. The plant stress hormone ethylene controls floral transition via DELLA-dependent regulation of floral meristem-identity genes. Achard P, et al. Proc Natl Acad Sci U S A, 2007 Apr 10. PMID 17389366, Free PMC Article
    5. Phosphatidic acid binds to and inhibits the activity of Arabidopsis CTR1. Testerink C, et al. J Exp Bot, 2007. PMID 18000017

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The SALT OVERLY SENSITIVE 2-CONSTITUTIVE TRIPLE RESPONSE1 module coordinates plant growth and salt tolerance in Arabidopsis.
      Title: The SALT OVERLY SENSITIVE 2-CONSTITUTIVE TRIPLE RESPONSE1 module coordinates plant growth and salt tolerance in Arabidopsis.
    2. Ethylene signaling in salt-stressed Arabidopsis thaliana ein2-1 and ctr1-1 mutants - A dissection of molecular mechanisms involved in acclimation.
      Title: Ethylene signaling in salt-stressed Arabidopsis thaliana ein2-1 and ctr1-1 mutants - A dissection of molecular mechanisms involved in acclimation.
    3. Epistatic interaction of CTR1 and ALF3 genes in Arabidopsis roots has been reported.
      Title: Features inheritance of root system Arabidopsis thaliana (L.) Heynh. the interaction of genes CTR1 AND ALF3, NPH4 and IAR2.
    4. Suc sustains rhythms in the dark by stabilizing GI protein, dependent on the F-box protein ZEITLUPE, and implicate CONSTITUTIVE TRIPLE RESPONSE1 (CTR1), a negative regulator of ethylene signaling.
      Title: Sucrose and Ethylene Signaling Interact to Modulate the Circadian Clock.
    5. the roles of CTR1-related proteins appear to have functionally diversified during land-plant evolution.
      Title: An Ancestral Role for CONSTITUTIVE TRIPLE RESPONSE1 Proteins in Both Ethylene and Abscisic Acid Signaling.
    6. The dark submergence-sensitive phenotypes of loh mutants were rescued by a ctr1-1 mutation. Thus, our findings demonstrate that unsaturation of VLC ceramides is a protective strategy for hypoxic tolerance in Arabidopsis
      Title: Unsaturation of very-long-chain ceramides protects plant from hypoxia-induced damages by modulating ethylene signaling in Arabidopsis.
    7. Ethylene (ET) affects auxin signaling through the central regulator CTR1 and that fungal-derived compounds, such as indole-3-acetic acid and indole-3-acetaldehyde, induce MPK6 activity.
      Title: Mitogen-Activated Protein Kinase 6 and Ethylene and Auxin Signaling Pathways Are Involved in Arabidopsis Root-System Architecture Alterations by Trichoderma atroviride.
    8. Ethylene receptor/CTR1 signaling is regulated by ethylene in Arabidopsis thaliana
      Title: Ethylene Regulates Levels of Ethylene Receptor/CTR1 Signaling Complexes in Arabidopsis thaliana.
    9. Protein phosphorylation plays a key role in ethylene signaling, which is mediated by the activities of ethylene receptors, CTR1, and RCN1.
      Title: Stable isotope metabolic labeling-based quantitative phosphoproteomic analysis of Arabidopsis mutants reveals ethylene-regulated time-dependent phosphoproteins and putative substrates of constitutive triple response 1 kinase.
    10. Genetic studies unveiled the existence of are1-1 mutation in the ctr1-1 mutant, as a second-site modifier which confers root-specific ethylene-resistance.
      Title: Genetic identification of a second site modifier of ctr1-1 that controls ethylene-responsive and gravitropic root growth in Arabidopsis thaliana.
    Submit: New GeneRIF Correction See all GeneRIFs (17)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_120454.4
    NM_180429.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity HDA PubMed 
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine/tyrosine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within gibberellin biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of ethylene-activated signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within protein autophosphorylation HDA PubMed 
    acts_upstream_of_or_within regulation of post-embryonic root development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of stem cell division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of timing of transition from vegetative to reproductive phase IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to ethylene IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to fructose IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to hypoxia IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to sucrose IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within sugar mediated signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    Protein kinase superfamily protein
    NP_195993.1
    • CONSTITUTIVE TRIPLE RESPONSE 1 (CTR1); CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Serine/threonine-protein kinase domain (InterPro:IPR002290), Serine-threonine/tyrosine-protein kinase (InterPro:IPR001245), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271), Protein kinase, catalytic domain (InterPro:IPR000719), Tyrosine-protein kinase, catalytic domain (InterPro:IPR020635); BEST Arabidopsis thaliana protein match is: Protein kinase superfamily protein (TAIR:AT4G24480.1); Has 126606 Blast hits to 124675 proteins in 4966 species: Archae - 112; Bacteria - 13843; Metazoa - 48138; Fungi - 11278; Plants - 33351; Viruses - 509; Other Eukaryotes - 19375 (source: NCBI BLink).
    NP_850760.1
    • CONSTITUTIVE TRIPLE RESPONSE 1 (CTR1); CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Serine/threonine-protein kinase domain (InterPro:IPR002290), Serine-threonine/tyrosine-protein kinase (InterPro:IPR001245), Serine/threonine-protein kinase, active site (InterPro:IPR008271), Protein kinase-like domain (InterPro:IPR011009), Protein kinase, catalytic domain (InterPro:IPR000719), Tyrosine-protein kinase, catalytic domain (InterPro:IPR020635); BEST Arabidopsis thaliana protein match is: Protein kinase superfamily protein (TAIR:AT4G24480.1); Has 126606 Blast hits to 124675 proteins in 4966 species: Archae - 112; Bacteria - 13843; Metazoa - 48138; Fungi - 11278; Plants - 33351; Viruses - 509; Other Eukaryotes - 19375 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      974360..979849 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_180429.4 → NP_850760.1  Protein kinase superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_850760.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q05609
      UniProtKB/TrEMBL
      A0A178UAE5, A0A5S9Y1U0, Q0WUI6
      Conserved Domains (3) summary
      smart00219
      Location:551 → 805
      TyrKc; Tyrosine kinase, catalytic domain
      cd13999
      Location:557 → 805
      STKc_MAP3K-like; Catalytic domain of Mitogen-Activated Protein Kinase (MAPK) Kinase Kinase-like Serine/Threonine kinases
      pfam14381
      Location:208 → 413
      EDR1; Ethylene-responsive protein kinase Le-CTR1

    2. NM_120454.4 → NP_195993.1  Protein kinase superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_195993.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q05609
      UniProtKB/TrEMBL
      A0A178UAE5, A0A5S9Y1U0, Q0WUI6
      Conserved Domains (3) summary
      smart00219
      Location:551 → 805
      TyrKc; Tyrosine kinase, catalytic domain
      cd13999
      Location:557 → 805
      STKc_MAP3K-like; Catalytic domain of Mitogen-Activated Protein Kinase (MAPK) Kinase Kinase-like Serine/Threonine kinases
      pfam14381
      Location:208 → 413
      EDR1; Ethylene-responsive protein kinase Le-CTR1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q05609.1

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