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    TPR7 Tetratricopeptide repeat (TPR)-like superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 832259, updated on 18-Sep-2024

    Summary

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    Official Symbol
    TPR7
    Official Full Name
    Tetratricopeptide repeat (TPR)-like superfamily protein
    Primary source
    TAIR:AT5G21990
    Locus tag
    AT5G21990
    See related
    Araport:AT5G21990
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtTPR7; OEP61; outer envelope protein 61; tetratricopeptide repeat 7
    Summary
    Encodes one of the 36 carboxylate clamp (CC)-tetratricopeptide repeat (TPR) proteins (Prasad 2010, Pubmed ID: 20856808). Functions as a chaperone receptor at the chloroplast outer envelope, mediating Hsp70-dependent protein targeting to chloroplasts. It has been localized to the ER membrane, interacts with the Sec translocon, and has a potential function in post-translational protein transport into the ER.
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    Genomic context

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    See TPR7 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    11
    Sequence:
    Chromosome: 5; NC_003076.8 (7273071..7276579)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene miscRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene RING-H2 group F2A Neighboring gene replication factor C1 Neighboring gene Calcium-dependent phosphotriesterase superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. AtTPR7 as part of the Arabidopsis Sec post-translocon. Schweiger R, et al. Plant Signal Behav, 2013 Aug. PMID 23759546, Free PMC Article
    2. AtTPR7 is a chaperone-docking protein of the Sec translocon in Arabidopsis. Schweiger R, et al. J Cell Sci, 2012 Nov 1. PMID 22899711
    3. OEP61 is a chaperone receptor at the plastid outer envelope. von Loeffelholz O, et al. Biochem J, 2011 Aug 15. PMID 21612577, Free PMC Article
    4. Quantification of interaction strengths between chaperones and tetratricopeptide repeat domain-containing membrane proteins. Schweiger R, et al. J Biol Chem, 2013 Oct 18. PMID 24036116, Free PMC Article
    5. Study of receptor-chaperone interactions using the optical technique of spectroscopic ellipsometry. Kriechbaumer V, et al. Biophys J, 2011 Jul 20. PMID 21767504, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_147882.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cytosol to endoplasmic reticulum transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast outer membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in intracellular anatomical structure IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    located_in plastid HDA PubMed 

    General protein information

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    Preferred Names
    Tetratricopeptide repeat (TPR)-like superfamily protein
    NP_680187.2
    • Tetratricopeptide repeat (TPR)-like superfamily protein; FUNCTIONS IN: binding; INVOLVED IN: protein folding; LOCATED IN: cellular_component unknown; EXPRESSED IN: cultured cell; CONTAINS InterPro DOMAIN/s: Tetratricopeptide TPR-1 (InterPro:IPR001440), Tetratricopeptide-like helical (InterPro:IPR011990), Tetratricopeptide repeat-containing (InterPro:IPR013026), Tetratricopeptide repeat (InterPro:IPR019734), Peptidyl-prolyl cis-trans isomerase, FKBP-type (InterPro:IPR001179); BEST Arabidopsis thaliana protein match is: FKBP-type peptidyl-prolyl cis-trans isomerase family protein (TAIR:AT5G48570.1); Has 3652 Blast hits to 3437 proteins in 299 species: Archae - 17; Bacteria - 74; Metazoa - 1859; Fungi - 377; Plants - 620; Viruses - 0; Other Eukaryotes - 705 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      7273071..7276579
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_147882.3 → NP_680187.2  Tetratricopeptide repeat (TPR)-like superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_680187.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B7ZWR6, Q8GWM6, Q9C588
      UniProtKB/TrEMBL
      A0A178UNB9, A0A5S9Y642, A0A7G2FAA7
      Conserved Domains (2) summary
      TIGR00990
      Location:30 → 204
      3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
      sd00006
      Location:103 → 134
      TPR; TPR repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B7ZWR6.1

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