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    UGD3 UDP-glucose 6-dehydrogenase family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 831402, updated on 18-Sep-2024

    Summary

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    Official Symbol
    UGD3
    Official Full Name
    UDP-glucose 6-dehydrogenase family protein
    Primary source
    TAIR:AT5G15490
    Locus tag
    AT5G15490
    See related
    Araport:AT5G15490
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    T20K14.100; T20K14_100; UDP-glucose dehydrogenase 3
    Summary
    Encodes one of four UDP-glucose dehydrogenase UGD) genes. Mutation of this gene in combination with UGD2 leads to swollen plant cell walls and severe developmental defects associated with changes in pectic polysaccharides.
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    Genomic context

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    See UGD3 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    2
    Sequence:
    Chromosome: 5; NC_003076.8 (5027638..5030245, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene galacturonosyltransferase 14 Neighboring gene C2H2-type zinc finger family protein Neighboring gene Ankyrin repeat family protein Neighboring gene TPX2 (targeting protein for Xklp2) protein family

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Down-regulation of UDP-glucuronic acid biosynthesis leads to swollen plant cell walls and severe developmental defects associated with changes in pectic polysaccharides. Reboul R, et al. J Biol Chem, 2011 Nov 18. PMID 21949134, Free PMC Article
    2. Genome-wide analysis of the UDP-glucose dehydrogenase gene family in Arabidopsis, a key enzyme for matrix polysaccharides in cell walls. Klinghammer M, et al. J Exp Bot, 2007. PMID 18057039
    3. The 14-3-3 isoforms chi and epsilon differentially bind client proteins from developing Arabidopsis seed. Swatek KN, et al. J Proteome Res, 2011 Sep 2. PMID 21766784
    4. Arabidopsis cell wall proteome defined using multidimensional protein identification technology. Bayer EM, et al. Proteomics, 2006 Jan. PMID 16287169
    5. Advanced proteomic analyses yield a deep catalog of ubiquitylation targets in Arabidopsis. Kim DY, et al. Plant Cell, 2013 May. PMID 23667124, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_121553.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables NAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables UDP-glucose 6-dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables UDP-glucose 6-dehydrogenase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in UDP-glucuronate biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in UDP-glucuronate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within carbohydrate metabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within cell wall pectin metabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plant-type cell wall HDA PubMed 

    General protein information

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    Preferred Names
    UDP-glucose 6-dehydrogenase family protein
    NP_197053.1
    • UDP-glucose 6-dehydrogenase family protein; FUNCTIONS IN: in 7 functions; INVOLVED IN: oxidation reduction, metabolic process; LOCATED IN: cytosol, cell wall, nucleus; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: UDP-glucose/GDP-mannose dehydrogenase, N-terminal (InterPro:IPR001732), 6-phosphogluconate dehydrogenase, C-terminal-like (InterPro:IPR008927), Dehydrogenase, multihelical (InterPro:IPR013328), UDP-glucose/GDP-mannose dehydrogenase, dimerisation and substrate-binding domain (InterPro:IPR014028), UDP-glucose/GDP-mannose dehydrogenase, C-terminal (InterPro:IPR014027), NAD(P)-binding domain (InterPro:IPR016040), UDP-glucose/GDP-mannose dehydrogenase, dimerisation (InterPro:IPR014026), Nucleotide sugar dehydrogenase (InterPro:IPR017476); BEST Arabidopsis thaliana protein match is: UDP-glucose 6-dehydrogenase family protein (TAIR:AT3G29360.2); Has 13373 Blast hits to 13344 proteins in 2170 species: Archae - 309; Bacteria - 7111; Metazoa - 214; Fungi - 99; Plants - 213; Viruses - 14; Other Eukaryotes - 5413 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      5027638..5030245 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_121553.4 → NP_197053.1  UDP-glucose 6-dehydrogenase family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_197053.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9LF33
      UniProtKB/TrEMBL
      A0A178UJW9, A0A178VPC3, A0A5S9XH23, A0A5S9Y4C2
      Conserved Domains (1) summary
      PLN02353
      Location:1 → 473
      PLN02353; probable UDP-glucose 6-dehydrogenase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LF33.1

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