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    HSD4 hydroxysteroid dehydrogenase 4 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 835128, updated on 18-Sep-2024

    Summary

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    Official Symbol
    HSD4
    Official Full Name
    hydroxysteroid dehydrogenase 4
    Primary source
    TAIR:AT5G50590
    Locus tag
    AT5G50590
    See related
    Araport:AT5G50590
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtHSD4; hydroxysteroid dehydrogenase 4; MFB16.20
    Summary
    Encodes a putative hydroxysteroid dehydrogenase (HSD). Genes that encode HSD include: At5g50600 and At5g50700 (HSD1), At3g47350(HSD2), At3g47360(HSD3), At5g50590 and At5g50690(HSD4), At5g50770(HSD6) (Plant Cell Physiology 50:1463). Two copies of HSD1 and HSD4 exist due to a gene duplication event. In Plant Physiology 145:87, At5g50690 is HSD7, At4g10020 is HSD5.
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    Genomic context

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    See HSD4 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    5
    Sequence:
    Chromosome: 5; NC_003076.8 (20587936..20589490)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Squamosa promoter-binding protein-like (SBP domain) transcription factor family protein Neighboring gene SUMO-activating enzyme 1B Neighboring gene hydroxysteroid dehydrogenase 1 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evidence for network evolution in an Arabidopsis interactome map. Arabidopsis Interactome Mapping Consortium. Science, 2011 Jul 29. PMID 21798944, Free PMC Article
    2. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Gene Ontology Provided by TAIR

    Component Evidence Code Pubs
    located_in extracellular region ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    hydroxysteroid dehydrogenase 4
    NP_199871.1
    • hydroxysteroid dehydrogenase 4 (HSD4); FUNCTIONS IN: oxidoreductase activity, binding, catalytic activity; INVOLVED IN: oxidation reduction, metabolic process; LOCATED IN: endomembrane system; CONTAINS InterPro DOMAIN/s: Short-chain dehydrogenase/reductase, conserved site (InterPro:IPR020904), NAD(P)-binding domain (InterPro:IPR016040), Glucose/ribitol dehydrogenase (InterPro:IPR002347), Short-chain dehydrogenase/reductase SDR (InterPro:IPR002198); BEST Arabidopsis thaliana protein match is: hydroxysteroid dehydrogenase 7 (TAIR:AT5G50690.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      20587936..20589490
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001344899.1 → NP_001331862.1  hydroxysteroid dehydrogenase 4 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8BF42, A0A5S9YCR9, A0A654G9R1

    2. NM_124447.2 → NP_199871.1  hydroxysteroid dehydrogenase 4 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_199871.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P0DKC7, Q9FGP2, Q9LUF2
      UniProtKB/TrEMBL
      A0A5S9YCR9, A0A654G9R1
      Conserved Domains (1) summary
      cd05332
      Location:45 → 295
      11beta-HSD1_like_SDR_c; 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0DKC7.1
    Q9LUF2.2

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