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    PI-4KBETA2 phosphatidylinositol 4-OH kinase beta2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 830794, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PI-4KBETA2
    Official Full Name
    phosphatidylinositol 4-OH kinase beta2
    Primary source
    TAIR:AT5G09350
    Locus tag
    AT5G09350
    See related
    Araport:AT5G09350
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    phosphatidylinositol 4-OH kinase beta2; PHOSPHATIDYLINOSITOL 4-OH KINASE BETA2; PI4KBETA2; T5E8.150; T5E8_150
    Summary
    Encodes a phosphatidylinositol 4-OH kinase, PI-4Kbeta2. Arabidopsis contains 12 PI-4Ks in three separate families: PI-4Kalphs, PI-4kbeta, and PI-4Kgamma. PI-4Kbeta2 is 83% identical to PI-4kbeta1 encoded by At5g64070. Important for polarized root hair growth as the loss of this gene and its close relative PI-4kbeta1, leads to the formation of abnormal root hairs.
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    Genomic context

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    See PI-4KBETA2 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    16
    Sequence:
    Chromosome: 5; NC_003076.8 (2899001..2906160, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene Ubiquitin family protein Neighboring gene tRNA-Leu Neighboring gene laccase 14 Neighboring gene Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. PI4KIIIβ Activity Regulates Lateral Root Formation Driven by Endocytic Trafficking to the Vacuole. Rubilar-Hernández C, et al. Plant Physiol, 2019 Sep. PMID 31285293, Free PMC Article
    2. A dual role for cell plate-associated PI4Kβ in endocytosis and phragmoplast dynamics during plant somatic cytokinesis. Lin F, et al. EMBO J, 2019 Feb 15. PMID 30617084, Free PMC Article
    3. The Arabidopsis pi4kIIIβ1β2 double mutant is salicylic acid-overaccumulating: a new example of salicylic acid influence on plant stature. Janda M, et al. Plant Signal Behav, 2014. PMID 25482755, Free PMC Article
    4. Constitutive salicylic acid accumulation in pi4kIIIβ1β2 Arabidopsis plants stunts rosette but not root growth. Sašek V, et al. New Phytol, 2014 Aug. PMID 24758581
    5. A plant 126-kDa phosphatidylinositol 4-kinase with a novel repeat structure. Cloning and functional expression in baculovirus-infected insect cells. Xue HW, et al. J Biol Chem, 1999 Feb 26. PMID 10026194

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PI4KIIIbeta Activity Regulates Lateral Root Formation Driven by Endocytic Trafficking to the Vacuole.
      Title: PI4KIIIβ Activity Regulates Lateral Root Formation Driven by Endocytic Trafficking to the Vacuole.
    2. PI4Kbeta1 and PI4Kbeta2 regulate microtubule dynamics in Arabidopsis in both cytokinetic and interphase root cells. [pi4kbeta2]
      Title: A dual role for cell plate-associated PI4Kβ in endocytosis and phragmoplast dynamics during plant somatic cytokinesis.
    3. pi4kIIIbeta1beta2 double mutant stunted rosette is due to high salicylic acid, while the short root length is not.
      Title: The Arabidopsis pi4kIIIβ1β2 double mutant is salicylic acid-overaccumulating: a new example of salicylic acid influence on plant stature.
    4. PI4KIIIbeta1 and PI4KIIIbeta2 are genetically upstream of EDS1 and need functional salicylic acid biosynthesis and perception through NPR1 to express the dwarf phenotype. [PI4KIIIbeta2]
      Title: Constitutive salicylic acid accumulation in pi4kIIIβ1β2 Arabidopsis plants stunts rosette but not root growth.
    5. AtPI4KIIIbeta1 and AtPI4KIIIbeta2 can both act upstream of the PI-PLC.
      Title: Arabidopsis type-III phosphatidylinositol 4-kinases β1 and β2 are upstream of the phospholipase C pathway triggered by cold exposure.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    NM_120971.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol 4-kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within phosphatidylinositol biosynthetic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in phosphatidylinositol phosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within pollen tube growth IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within root hair cell tip growth IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasmic vesicle membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    phosphatidylinositol 4-OH kinase beta2
    NP_196497.1
    • phosphatidylinositol 4-OH kinase beta2 (PI-4KBETA2); FUNCTIONS IN: inositol or phosphatidylinositol kinase activity, binding, phosphotransferase activity, alcohol group as acceptor; INVOLVED IN: phosphoinositide biosynthetic process, root hair cell tip growth, pollen tube growth; CONTAINS InterPro DOMAIN/s: Phosphatidylinositol 3-/4-kinase, catalytic (InterPro:IPR000403), Phosphatidylinositol Kinase (InterPro:IPR015433), Armadillo-type fold (InterPro:IPR016024), Phosphatidylinositol 3/4-kinase, conserved site (InterPro:IPR018936), Protein kinase-like domain (InterPro:IPR011009); BEST Arabidopsis thaliana protein match is: phosphatidylinositol 4-OH kinase beta1 (TAIR:AT5G64070.1); Has 7223 Blast hits to 5858 proteins in 401 species: Archae - 10; Bacteria - 146; Metazoa - 2545; Fungi - 1184; Plants - 443; Viruses - 52; Other Eukaryotes - 2843 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      2899001..2906160 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_120971.3 → NP_196497.1  phosphatidylinositol 4-OH kinase beta2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_196497.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0WPX9, Q9FY80
      UniProtKB/TrEMBL
      A0A178UGA7, A0A5S9Y2P6
      Conserved Domains (2) summary
      COG5192
      Location:240 → 405
      BMS1; GTP-binding protein required for 40S ribosome biogenesis [Translation, ribosomal structure and biogenesis]
      cd05168
      Location:826 → 1115
      PI4Kc_III_beta; Catalytic domain of Type III Phosphoinositide 4-kinase beta
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0WPX9.1

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