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    pescadillo-like protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 831303, updated on 18-Sep-2024

    Summary

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    Official Full Name
    pescadillo-like protein
    Primary source
    TAIR:AT5G14520
    Locus tag
    AT5G14520
    See related
    Araport:AT5G14520
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    PES; PESCADILLO; T15N1.10; T15N1_10
    Summary
    Encodes a nucleolar protein that plays an essential role in cell growth and survival through its regulation of ribosome biogenesis and mitotic progression.
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    Genomic context

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    Location:
    chromosome: 5
    Exon count:
    13
    Sequence:
    Chromosome: 5; NC_003076.8 (4680540..4684472, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene aldose 1-epimerase family protein Neighboring gene ARM repeat superfamily protein Neighboring gene uncharacterized protein Neighboring gene Transducin/WD40 repeat-like superfamily protein Neighboring gene basic salivary proline-rich-like protein (DUF1421)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional characterization of the ribosome biogenesis factors PES, BOP1, and WDR12 (PeBoW), and mechanisms of defective cell growth and proliferation caused by PeBoW deficiency in Arabidopsis. Ahn CS, et al. J Exp Bot, 2016 Sep. PMID 27440937, Free PMC Article
    2. The nucleolar GTPase nucleostemin-like 1 plays a role in plant growth and senescence by modulating ribosome biogenesis. Jeon Y, et al. J Exp Bot, 2015 Oct. PMID 26163696, Free PMC Article
    3. Transcriptional regulation and functional involvement of the Arabidopsis pescadillo ortholog AtPES in root development. Zografidis A, et al. Plant Sci, 2014 Dec. PMID 25443833
    4. Pescadillo plays an essential role in plant cell growth and survival by modulating ribosome biogenesis. Cho HK, et al. Plant J, 2013 Nov. PMID 23909681
    5. Discovering the RNA-Binding Proteome of Plant Leaves with an Improved RNA Interactome Capture Method. Bach-Pages M, et al. Biomolecules, 2020 Apr 24. PMID 32344669, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. functional characterization and role in mechanisms of defective cell growth and proliferation caused by PeBoW deficiency
      Title: Functional characterization of the ribosome biogenesis factors PES, BOP1, and WDR12 (PeBoW), and mechanisms of defective cell growth and proliferation caused by PeBoW deficiency in Arabidopsis.
    2. AtPES is firmly regulated at the transcriptional level and the corresponding protein plays a role in root developmental processes. [AtPES]
      Title: Transcriptional regulation and functional involvement of the Arabidopsis pescadillo ortholog AtPES in root development.
    3. role in cell growth and survival through its regulation of ribosome biogenesis and mitotic progression
      Title: Pescadillo plays an essential role in plant cell growth and survival by modulating ribosome biogenesis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_121456.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within regulation of rRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of ribosome biogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    pescadillo-like protein
    NP_196956.1
    • pescadillo-related; FUNCTIONS IN: transcription coactivator activity; INVOLVED IN: cell proliferation; LOCATED IN: nucleolus, intracellular; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Pescadillo, N-terminal (InterPro:IPR010613), BRCT (InterPro:IPR001357); Has 503 Blast hits to 494 proteins in 230 species: Archae - 0; Bacteria - 0; Metazoa - 173; Fungi - 168; Plants - 48; Viruses - 0; Other Eukaryotes - 114 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      4680540..4684472 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_121456.4 → NP_196956.1  pescadillo-like protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_196956.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9LYK7
      UniProtKB/TrEMBL
      A0A178ULJ1, A0A5S9Y4E5
      Conserved Domains (2) summary
      COG5163
      Location:6 → 583
      NOP7; Protein required for biogenesis of the 60S ribosomal subunit [Translation, ribosomal structure and biogenesis]
      pfam06732
      Location:11 → 264
      Pescadillo_N; Pescadillo N-terminus
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LYK7.1

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