U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    KNU C2H2 and C2HC zinc fingers superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 831249, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    KNU
    Official Full Name
    C2H2 and C2HC zinc fingers superfamily protein
    Primary source
    TAIR:AT5G14010
    Locus tag
    AT5G14010
    See related
    Araport:AT5G14010
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    KNUCKLES; MAC12.2; MAC12_2
    Summary
    Encodes KNUCKLES (KNU), a C2H2-type zinc finger protein with a conserved transcriptional repression motif. Mediates the repression of WUS in floral meristem determinacy control.
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See KNU in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    1
    Sequence:
    Chromosome: 5; NC_003076.8 (4522149..4522935)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene NAC domain containing protein 84 Neighboring gene ncRNA Neighboring gene Endosomal targeting BRO1-like domain-containing protein Neighboring gene translocon-associated protein beta (TRAPB) family protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Robust control of floral meristem determinacy by position-specific multifunctions of KNUCKLES. Shang E, et al. Proc Natl Acad Sci U S A, 2021 Sep 7. PMID 34462349, Free PMC Article
    2. A timing mechanism for stem cell maintenance and differentiation in the Arabidopsis floral meristem. Sun B, et al. Genes Dev, 2009 Aug 1. PMID 19651987, Free PMC Article
    3. Integration of Transcriptional Repression and Polycomb-Mediated Silencing of WUSCHEL in Floral Meristems. Sun B, et al. Plant Cell, 2019 Jul. PMID 31068455, Free PMC Article
    4. At-MINI ZINC FINGER2 and Sl-INHIBITOR OF MERISTEM ACTIVITY, a Conserved Missing Link in the Regulation of Floral Meristem Termination in Arabidopsis and Tomato. Bollier N, et al. Plant Cell, 2018 Jan. PMID 29298836, Free PMC Article
    5. A PXY-Mediated Transcriptional Network Integrates Signaling Mechanisms to Control Vascular Development in Arabidopsis. Smit ME, et al. Plant Cell, 2020 Feb. PMID 31806676, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Robust control of floral meristem determinacy by position-specific multifunctions of KNUCKLES.
      Title: Robust control of floral meristem determinacy by position-specific multifunctions of KNUCKLES.
    2. KNU integrates initial transcriptional repression with polycomb-mediated stable silencing of WUS.
      Title: Integration of Transcriptional Repression and Polycomb-Mediated Silencing of WUSCHEL in Floral Meristems.
    Submit: New GeneRIF Correction

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription cis-regulatory region binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within floral meristem determinacy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of abscisic acid-activated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of DNA-templated transcription TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of flower development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    C2H2 and C2HC zinc fingers superfamily protein
    NP_196905.1
    • KNUCKLES (KNU); FUNCTIONS IN: sequence-specific DNA binding transcription factor activity, zinc ion binding, nucleic acid binding; INVOLVED IN: floral meristem determinacy, regulation of transcription, regulation of flower development; LOCATED IN: intracellular, chloroplast; CONTAINS InterPro DOMAIN/s: Zinc finger, C2H2-type (InterPro:IPR007087); BEST Arabidopsis thaliana protein match is: zinc finger protein 4 (TAIR:AT1G66140.1); Has 934 Blast hits to 934 proteins in 27 species: Archae - 0; Bacteria - 0; Metazoa - 0; Fungi - 0; Plants - 934; Viruses - 0; Other Eukaryotes - 0 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      4522149..4522935
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_121404.2 → NP_196905.1  C2H2 and C2HC zinc fingers superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_196905.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9FFX4
      UniProtKB/TrEMBL
      A0A178UJG4, A0A384L1F1, Q29Q53
      Conserved Domains (1) summary
      pfam13912
      Location:38 → 63
      zf-C2H2_6; C2H2-type zinc finger
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FFX4.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools