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    AGO10 Stabilizer of iron transporter SufD / Polynucleotidyl transferase [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 834403, updated on 18-Sep-2024

    Summary

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    Official Symbol
    AGO10
    Official Full Name
    Stabilizer of iron transporter SufD / Polynucleotidyl transferase
    Primary source
    TAIR:AT5G43810
    Locus tag
    AT5G43810
    See related
    Araport:AT5G43810
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARGONAUTE 10; ARGONAUTE PROTEIN 10; MQD19.17; MQD19_17; PINHEAD; PNH; ZLL; ZWILLE
    Summary
    Encodes Argonaute10, a member of the EIF2C (elongation initiation factor 2c)/ Argonaute class of proteins. Required to establish the central-peripheral organization of the embryo apex. Along with WUS and CLV genes, controls the relative organization of central zone and peripheral zone cells in meristems. Acts in embryonic provascular tissue potentiating WUSCHEL function during meristem development in the embryo. AGO10 specifically sequesters miR166/165 to regulate shoot apical meristem development.
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    Genomic context

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    See AGO10 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    21
    Sequence:
    Chromosome: 5; NC_003076.8 (17610744..17616907)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene Pentatricopeptide repeat (PPR) superfamily protein Neighboring gene pseudo Neighboring gene Pentatricopeptide repeat (PPR) superfamily protein Neighboring gene Pentatricopeptide repeat (PPR) superfamily protein Neighboring gene aluminum induced protein with YGL and LRDR motifs

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The molecular mechanism of microRNA duplex selectivity of Arabidopsis ARGONAUTE10. Xiao Y, et al. Nucleic Acids Res, 2022 Sep 23. PMID 35801914, Free PMC Article
    2. Regulation of ARGONAUTE10 Expression Enables Temporal and Spatial Precision in Axillary Meristem Initiation in Arabidopsis. Zhang C, et al. Dev Cell, 2020 Dec 7. PMID 33232670, Free PMC Article
    3. ZWILLE buffers meristem stability in Arabidopsis thaliana. Moussian B, et al. Dev Genes Evol, 2003 Nov. PMID 14564520
    4. ZLL/AGO10 maintains shoot meristem stem cells during Arabidopsis embryogenesis by down-regulating ARF2-mediated auxin response. Roodbarkelari F, et al. BMC Biol, 2015 Sep 10. PMID 26358077, Free PMC Article
    5. Arabidopsis Argonaute10 specifically sequesters miR166/165 to regulate shoot apical meristem development. Zhu H, et al. Cell, 2011 Apr 15. PMID 21496644, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ARGONAUTE10 controls cell fate specification and formative cell divisions in the Arabidopsis root.
      Title: ARGONAUTE10 controls cell fate specification and formative cell divisions in the Arabidopsis root.
    2. The molecular mechanism of microRNA duplex selectivity of Arabidopsis ARGONAUTE10.
      Title: The molecular mechanism of microRNA duplex selectivity of Arabidopsis ARGONAUTE10.
    3. Arabidopsis RBV is a conserved WD40 repeat protein that promotes microRNA biogenesis and ARGONAUTE1 loading.
      Title: Arabidopsis RBV is a conserved WD40 repeat protein that promotes microRNA biogenesis and ARGONAUTE1 loading.
    4. Regulation of ARGONAUTE10 Expression Enables Temporal and Spatial Precision in Axillary Meristem Initiation in Arabidopsis.
      Title: Regulation of ARGONAUTE10 Expression Enables Temporal and Spatial Precision in Axillary Meristem Initiation in Arabidopsis.
    5. the shoot regeneration inhibition determined by AGO10 functions via the repression of miR165/166.
      Title: ARGONAUTE10 Inhibits In Vitro Shoot Regeneration Via Repression of miR165/166 in Arabidopsis thaliana.
    6. The regulatory mechanism of AGO10 by which shoot apical meristem size is controlled under stress conditions.[LBD12-1]
      Title: The LBD12-1 Transcription Factor Suppresses Apical Meristem Size by Repressing Argonaute 10 Expression.
    7. AGO10 reduces miR165/6 accumulation by enhancing its degradation by SDN1 and SDN2 in vivo.
      Title: ARGONAUTE10 promotes the degradation of miR165/6 through the SDN1 and SDN2 exonucleases in Arabidopsis.
    8. data suggest that boundary-expressing HAN communicates with the meristem through the PNH, regulates floral organ development via JAG and BOP2, and maintains boundary morphology through CKX3 during flower development in Arabidopsis
      Title: HANABA TARANU (HAN) Bridges Meristem and Organ Primordia Boundaries through PINHEAD, JAGGED, BLADE-ON-PETIOLE2 and CYTOKININ OXIDASE 3 during Flower Development in Arabidopsis.
    9. Our results indicate that maintenance of shoot meristem stem cells by AGO10 involves negative regulation of auxin signaling and, via REV-mediated downregulation of ARF2 expression, auxin response.
      Title: ZLL/AGO10 maintains shoot meristem stem cells during Arabidopsis embryogenesis by down-regulating ARF2-mediated auxin response.
    10. AGO1, AGO2 and AGO10 promoted anti-TuMV defense in a modular way in various organs, with AGO2 providing a prominent antiviral role in leaves. AGO5, AGO7 and AGO10 had minor effects in leaves.
      Title: Roles and programming of Arabidopsis ARGONAUTE proteins during Turnip mosaic virus infection.
    Submit: New GeneRIF Correction See all GeneRIFs (18)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001203535.1
    NM_001344506.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables miRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables translation initiation factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within defense response to virus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within miRNA metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within primary shoot apical meristem specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of meristem structural organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of shoot apical meristem development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in somatic stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in plastid HDA PubMed 

    General protein information

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    Preferred Names
    Stabilizer of iron transporter SufD / Polynucleotidyl transferase
    NP_001190464.1
    • ZWILLE (ZLL); CONTAINS InterPro DOMAIN/s: Domain of unknown function DUF1785 (InterPro:IPR014811), Stem cell self-renewal protein Piwi (InterPro:IPR003165), Argonaute/Dicer protein, PAZ (InterPro:IPR003100), Polynucleotidyl transferase, ribonuclease H fold (InterPro:IPR012337); BEST Arabidopsis thaliana protein match is: Stabilizer of iron transporter SufD / Polynucleotidyl transferase (TAIR:AT1G48410.1).
    NP_199194.1
    • ZWILLE (ZLL); CONTAINS InterPro DOMAIN/s: Domain of unknown function DUF1785 (InterPro:IPR014811), Stem cell self-renewal protein Piwi (InterPro:IPR003165), Argonaute/Dicer protein, PAZ (InterPro:IPR003100), Polynucleotidyl transferase, ribonuclease H fold (InterPro:IPR012337); BEST Arabidopsis thaliana protein match is: Stabilizer of iron transporter SufD / Polynucleotidyl transferase (TAIR:AT1G48410.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      17610744..17616907
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_123748.3 → NP_199194.1  Stabilizer of iron transporter SufD / Polynucleotidyl transferase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_199194.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O49256, Q9XGW1
      UniProtKB/TrEMBL
      A0A178UP07, A0A5S9YBA6
      Conserved Domains (1) summary
      PLN03202
      Location:131 → 988
      PLN03202; protein argonaute; Provisional

    2. NM_001344505.1 → NP_001331600.1  Stabilizer of iron transporter SufD / Polynucleotidyl transferase [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O49256, Q9XGW1
      UniProtKB/TrEMBL
      A0A178UP07, A0A5S9YBA6
      Conserved Domains (1) summary
      PLN03202
      Location:131 → 988
      PLN03202; protein argonaute; Provisional

    3. NM_001203535.1 → NP_001190464.1  Stabilizer of iron transporter SufD / Polynucleotidyl transferase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001190464.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O49256, Q9XGW1
      UniProtKB/TrEMBL
      A0A178UP07, A0A5S9YBA6
      Conserved Domains (1) summary
      PLN03202
      Location:131 → 988
      PLN03202; protein argonaute; Provisional

    4. NM_001344506.1 → NP_001331599.1  Stabilizer of iron transporter SufD / Polynucleotidyl transferase [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O49256, Q9XGW1
      UniProtKB/TrEMBL
      A0A178UP07, A0A5S9YBA6
      Conserved Domains (1) summary
      PLN03202
      Location:131 → 988
      PLN03202; protein argonaute; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9XGW1.1

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