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    KAT5 peroxisomal 3-keto-acyl-CoA thiolase 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 834946, updated on 18-Sep-2024

    Summary

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    Official Symbol
    KAT5
    Official Full Name
    peroxisomal 3-keto-acyl-CoA thiolase 2
    Primary source
    TAIR:AT5G48880
    Locus tag
    AT5G48880
    See related
    Araport:AT5G48880
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    3-KETO-ACYL-COA THIOLASE; 3-KETO-ACYL-COENZYME A THIOLASE 5; K24G6.22; K24G6_22; peroxisomal 3-keto-acyl-CoA thiolase 2; PEROXISOMAL 3-KETO-ACYL-COA THIOLASE 2; PEROXISOMAL-3-KETO-ACYL-COA THIOLASE 1; PKT1; PKT2
    Summary
    Encodes a peroxisomal 3-keto-acyl-CoA thiolase 2 precursor. EC2.3.1.16 thiolases. AT5G48880.1 is named PKT1 and AT5G48880.2 is named PKT2.
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    Genomic context

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    See KAT5 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    14
    Sequence:
    Chromosome: 5; NC_003076.8 (19814395..19817955, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene Tetratricopeptide repeat (TPR)-like superfamily protein Neighboring gene uncharacterized protein Neighboring gene Small nuclear ribonucleoprotein family protein Neighboring gene C2H2-like zinc finger protein Neighboring gene Pectin lyase-like superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Peroxisomal plant 3-ketoacyl-CoA thiolase structure and activity are regulated by a sensitive redox switch. Pye VE, et al. J Biol Chem, 2010 Jul 30. PMID 20463027, Free PMC Article
    2. Knockout of the two evolutionarily conserved peroxisomal 3-ketoacyl-CoA thiolases in Arabidopsis recapitulates the abnormal inflorescence meristem 1 phenotype. Wiszniewski AA, et al. J Exp Bot, 2014 Dec. PMID 25297549, Free PMC Article
    3. Proteome analysis of Arabidopsis leaf peroxisomes reveals novel targeting peptides, metabolic pathways, and defense mechanisms. Reumann S, et al. Plant Cell, 2007 Oct. PMID 17951448, Free PMC Article
    4. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Peroxisomal KAT2 and KAT5 have partially redundant functions and operate downstream of AIM1 to provide beta-oxidation functions essential for inflorescence development and fertility.
      Title: Knockout of the two evolutionarily conserved peroxisomal 3-ketoacyl-CoA thiolases in Arabidopsis recapitulates the abnormal inflorescence meristem 1 phenotype.
    2. Peroxisomal plant 3-ketoacyl-CoA thiolase structure and activity are regulated by a sensitive redox swit
      Title: Peroxisomal plant 3-ketoacyl-CoA thiolase structure and activity are regulated by a sensitive redox switch.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    NM_001036960.2
    NM_001344808.1
    NM_124265.5
    NM_180826.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables acetyl-CoA C-acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within fatty acid oxidation TAS
    Traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in peroxisome HDA PubMed 

    General protein information

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    Preferred Names
    peroxisomal 3-keto-acyl-CoA thiolase 2
    NP_001032037.1
    • peroxisomal 3-keto-acyl-CoA thiolase 2; FUNCTIONS IN: transferase activity, transferring acyl groups other than amino-acyl groups, catalytic activity, acetyl-CoA C-acyltransferase activity; INVOLVED IN: fatty acid oxidation; LOCATED IN: peroxisome; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Thiolase (InterPro:IPR002155), Thiolase, active site (InterPro:IPR020610), Thiolase, N-terminal (InterPro:IPR020616), Thiolase, conserved site (InterPro:IPR020613), Thiolase, C-terminal (InterPro:IPR020617), Thiolase-like, subgroup (InterPro:IPR016038), Thiolase-like (InterPro:IPR016039), Thiolase, acyl-enzyme intermediate active site (InterPro:IPR020615); BEST Arabidopsis thaliana protein match is: peroxisomal 3-ketoacyl-CoA thiolase 3 (TAIR:AT2G33150.1); Has 22215 Blast hits to 22197 proteins in 2240 species: Archae - 413; Bacteria - 13972; Metazoa - 985; Fungi - 661; Plants - 288; Viruses - 0; Other Eukaryotes - 5896 (source: NCBI BLink).
    NP_568704.2
    • peroxisomal 3-keto-acyl-CoA thiolase 2 (PKT2); FUNCTIONS IN: transferase activity, transferring acyl groups other than amino-acyl groups, catalytic activity, acetyl-CoA C-acyltransferase activity; INVOLVED IN: fatty acid oxidation; LOCATED IN: peroxisome; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Thiolase (InterPro:IPR002155), Thiolase, active site (InterPro:IPR020610), Thiolase, N-terminal (InterPro:IPR020616), Thiolase, conserved site (InterPro:IPR020613), Thiolase, C-terminal (InterPro:IPR020617), Thiolase-like, subgroup (InterPro:IPR016038), Thiolase-like (InterPro:IPR016039), Thiolase, acyl-enzyme intermediate active site (InterPro:IPR020615); BEST Arabidopsis thaliana protein match is: peroxisomal 3-ketoacyl-CoA thiolase 3 (TAIR:AT2G33150.1); Has 22215 Blast hits to 22197 proteins in 2240 species: Archae - 413; Bacteria - 13972; Metazoa - 985; Fungi - 661; Plants - 288; Viruses - 0; Other Eukaryotes - 5896 (source: NCBI BLink).
    NP_851157.1
    • PEROXISOMAL-3-KETO-ACYL-COA THIOLASE 1 (PKT1); FUNCTIONS IN: transferase activity, transferring acyl groups other than amino-acyl groups, catalytic activity, acetyl-CoA C-acyltransferase activity; INVOLVED IN: fatty acid oxidation; LOCATED IN: peroxisome; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Thiolase (InterPro:IPR002155), Thiolase, active site (InterPro:IPR020610), Thiolase, N-terminal (InterPro:IPR020616), Thiolase, conserved site (InterPro:IPR020613), Thiolase, C-terminal (InterPro:IPR020617), Thiolase-like, subgroup (InterPro:IPR016038), Thiolase-like (InterPro:IPR016039), Thiolase, acyl-enzyme intermediate active site (InterPro:IPR020615); BEST Arabidopsis thaliana protein match is: peroxisomal 3-ketoacyl-CoA thiolase 4 (TAIR:AT1G04710.1); Has 22254 Blast hits to 22236 proteins in 2248 species: Archae - 414; Bacteria - 14009; Metazoa - 985; Fungi - 662; Plants - 288; Viruses - 0; Other Eukaryotes - 5896 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      19814395..19817955 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_180826.4 → NP_851157.1  peroxisomal 3-keto-acyl-CoA thiolase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_851157.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UD50, Q0WLJ0
      Conserved Domains (2) summary
      PLN02287
      Location:1 → 414
      PLN02287; 3-ketoacyl-CoA thiolase
      cd00751
      Location:9 → 396
      thiolase; Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and ...

    2. NM_124265.5 → NP_568704.2  peroxisomal 3-keto-acyl-CoA thiolase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_568704.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O65339, Q570C8, Q9S774
      UniProtKB/TrEMBL
      A0A178UEC0, A0A5S9YCB1, A0A654G9U6
      Conserved Domains (1) summary
      PLN02287
      Location:1 → 457
      PLN02287; 3-ketoacyl-CoA thiolase

    3. NM_001036960.2 → NP_001032037.1  peroxisomal 3-keto-acyl-CoA thiolase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001032037.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O65339, Q570C8, Q9S774
      UniProtKB/TrEMBL
      A0A178UEC0, A0A5S9YCB1, A0A654G9U6
      Conserved Domains (1) summary
      PLN02287
      Location:1 → 457
      PLN02287; 3-ketoacyl-CoA thiolase

    4. NM_001344808.1 → NP_001331840.1  peroxisomal 3-keto-acyl-CoA thiolase 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O65339, Q570C8, Q9S774
      UniProtKB/TrEMBL
      A0A178UEC0, A0A5S9YCB1, A0A654G9U6
      Conserved Domains (1) summary
      PLN02287
      Location:1 → 457
      PLN02287; 3-ketoacyl-CoA thiolase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q570C8.2

    Gene LinkOut

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