APC3 Mitochondrial substrate carrier family protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: APC3
Official Full Name: Mitochondrial substrate carrier family protein
Primary source: TAIR:AT5G07320
Locus tag: AT5G07320
See related: Araport:AT5G07320
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATP/phosphate carrier 3; T2I1.30; T2I1_30
Summary: Encodes a mitochondrial ATP-Mg/Pi transporter. Binds to calcium.
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Genomic context

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See APC3 in Genome Data Viewer

Location:: chromosome: 5

Exon count:: 4

Sequence:: Chromosome: 5; NC_003076.8 (2309863..2312346)

Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

direct measurements of Mg(2+), Mn(2+), Fe(2+), Zn(2+) and Cu(2+) showed that they are cotransported with ATP by both hAPCs and AtAPCs. It is likely that in vivo APCs transport free ATP and ATP-Mg complex to different degrees, and probably trace amounts of other Metals(2+) in complex with ATP. [APC3]
Title: Mitochondrial ATP-Mg/phosphate carriers transport divalent inorganic cations in complex with ATP.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_120814.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables ADP transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables AMP transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables ATP transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables calcium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables calcium ion transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables phosphate transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within ADP transport	IDA Inferred from Direct Assay more info	PubMed
involved_in ADP transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within AMP transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within ATP transport	IDA Inferred from Direct Assay more info	PubMed
involved_in ATP transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within ATP transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in calcium ion transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within monoatomic anion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within monoatomic cation transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within nucleotide transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within phosphate ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in phosphate ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within xenobiotic transmembrane transport	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in chloroplast	ISM Inferred from Sequence Model more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Mitochondrial substrate carrier family protein

NP_196349.1

Mitochondrial substrate carrier family protein; FUNCTIONS IN: binding, calcium ion binding; INVOLVED IN: transport, transmembrane transport; LOCATED IN: mitochondrial inner membrane, membrane; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: EF-Hand 1, calcium-binding site (InterPro:IPR018247), Mitochondrial substrate carrier (InterPro:IPR001993), EF-hand-like domain (InterPro:IPR011992), Calcium-binding EF-hand (InterPro:IPR002048), Mitochondrial carrier protein (InterPro:IPR002067), EF-HAND 2 (InterPro:IPR018249), Mitochondrial substrate/solute carrier (InterPro:IPR018108); BEST Arabidopsis thaliana protein match is: Mitochondrial substrate carrier family protein (TAIR:AT5G61810.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003076.8 Reference assembly

Range

2309863..2312346

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_120814.3 → NP_196349.1 Mitochondrial substrate carrier family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_196349.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9LY28

UniProtKB/TrEMBL

A0A178U8U1, A0A5S9Y2I6

Conserved Domains (3) summary

COG5126
Location:31 → 169

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

PTZ00169
Location:218 → 476

PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional

pfam00153
Location:292 → 381

Mito_carr; Mitochondrial carrier protein