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    ARGAH2 Arginase/deacetylase superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 826458, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ARGAH2
    Official Full Name
    Arginase/deacetylase superfamily protein
    Primary source
    TAIR:AT4G08870
    Locus tag
    AT4G08870
    See related
    Araport:AT4G08870
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    arginine amidohydrolase 2; T3H13.10; T3H13_10
    Summary
    Encodes one of the two arginase in the genome. Gene expression is enhanced by methyl jasmonate treatment. It is involved in the defense response to B.cinerea.
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    Genomic context

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    See ARGAH2 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    6
    Sequence:
    Chromosome: 4; NC_003075.7 (5646395..5648868, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene Leucine-rich repeat receptor-like protein kinase family protein Neighboring gene pseudo Neighboring gene ncRNA Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Overexpression of arginase in Arabidopsis thaliana influences defence responses against Botrytis cinerea. Brauc S, et al. Plant Biol (Stuttg), 2012 Mar. PMID 22188168
    2. Dual functioning of plant arginases provides a third route for putrescine synthesis. Patel J, et al. Plant Sci, 2017 Sep. PMID 28716421
    3. Manipulation of arginase expression modulates abiotic stress tolerance in Arabidopsis: effect on arginine metabolism and ROS accumulation. Shi H, et al. J Exp Bot, 2013 Mar. PMID 23378380, Free PMC Article
    4. Analysis of Arabidopsis arginase gene transcription patterns indicates specific biological functions for recently diverged paralogs. Brownfield DL, et al. Plant Mol Biol, 2008 Jul. PMID 18425591
    5. Arginase-negative mutants of Arabidopsis exhibit increased nitric oxide signaling in root development. Flores T, et al. Plant Physiol, 2008 Aug. PMID 18567826, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. AtARGAHs negatively regulate many abiotic stress tolerances, at least partially, attribute to their roles in modulating arginine metabolism and reactive oxygen species accumulation. [AtARGAH2]
      Title: Manipulation of arginase expression modulates abiotic stress tolerance in Arabidopsis: effect on arginine metabolism and ROS accumulation.
    2. Gene mutations within ARGAH1 or ARGAH2 are associated with increased nitric oxide signaling in root development. [ARGAH2]
      Title: Arginase-negative mutants of Arabidopsis exhibit increased nitric oxide signaling in root development.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001036522.3
    NM_116956.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables agmatinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables arginase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables arginase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables cobalt ion binding HDA PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within defense response to fungus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within ornithine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within proline metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within putrescine biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within putrescine biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in putrescine biosynthetic process from arginine, using agmatinase IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within putrescine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within tyrosine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in urea cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chloroplast stroma IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol HDA PubMed 
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    Arginase/deacetylase superfamily protein
    NP_001031599.1
    • Arginase/deacetylase superfamily protein; FUNCTIONS IN: arginase activity, cobalt ion binding, agmatinase activity; INVOLVED IN: response to jasmonic acid stimulus, polyamine metabolic process; LOCATED IN: mitochondrion; EXPRESSED IN: sepal vascular system, cotyledon vascular system, root vascular system, style, leaf; EXPRESSED DURING: seedling growth; CONTAINS InterPro DOMAIN/s: Ureohydrolase (InterPro:IPR006035); BEST Arabidopsis thaliana protein match is: arginase (TAIR:AT4G08900.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_192626.1
    • Arginase/deacetylase superfamily protein; FUNCTIONS IN: arginase activity, cobalt ion binding, agmatinase activity; INVOLVED IN: response to jasmonic acid stimulus, polyamine metabolic process; LOCATED IN: mitochondrion, chloroplast; EXPRESSED IN: sepal vascular system, cotyledon vascular system, root vascular system, style, leaf; EXPRESSED DURING: seedling growth; CONTAINS InterPro DOMAIN/s: Ureohydrolase (InterPro:IPR006035); BEST Arabidopsis thaliana protein match is: arginase (TAIR:AT4G08900.1); Has 8845 Blast hits to 8843 proteins in 1673 species: Archae - 297; Bacteria - 4692; Metazoa - 410; Fungi - 370; Plants - 72; Viruses - 0; Other Eukaryotes - 3004 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      5646395..5648868 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_116956.4 → NP_192626.1  Arginase/deacetylase superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_192626.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9ZPF5
      UniProtKB/TrEMBL
      A0A178V1K8, A0A654FMG0
      Conserved Domains (1) summary
      PLN02615
      Location:1 → 344
      PLN02615; arginase

    2. NM_001036522.3 → NP_001031599.1  Arginase/deacetylase superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001031599.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B9DFC0
      Conserved Domains (1) summary
      cl17011
      Location:1 → 258
      Arginase_HDAC; Arginase-like and histone-like hydrolases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ZPF5.1

    Gene LinkOut

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