MAPKKK9 mitogen-activated protein kinase kinase kinase 9 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: MAPKKK9
Official Full Name: mitogen-activated protein kinase kinase kinase 9
Primary source: TAIR:AT4G08480
Locus tag: AT4G08480
See related: Araport:AT4G08480
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: MAPK/ERK KINASE KINASE 2; MEKK2; mitogen-activated protein kinase kinase kinase 9; SUMM1; suppressor of mkk1 mkk2 1; T15F16.3; T15F16_3
Summary: Encodes a member of the A1 subgroup of the MEKK (MAPK/ERK kinase kinase) family. MEKK is another name for Mitogen-Activated Protein Kinase Kinase Kinase (MAPKKK or MAP3K). This subgroup has four members: At4g08500 (MEKK1, also known as ARAKIN, MAP3Kb1, MAPKKK8), At4g08480 (MEKK2, also known as MAP3Kb4, MAPKKK9), At4g08470 (MEKK3, also known as MAP3Kb3, MAPKKK10) and At4g12020 (MEKK4, also known as MAP3Kb5, MAPKKK11, WRKY19). Nomenclatures for mitogen-activated protein kinases are described in Trends in Plant Science 2002, 7(7):301.
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Genomic context

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See MAPKKK9 in Genome Data Viewer

Location:: chromosome: 4

Exon count:: 9

Sequence:: Chromosome: 4; NC_003075.7 (5387351..5391575, complement)

Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MEKK2 inhibits activation of MAP kinases in Arabidopsis.
Title: MEKK2 inhibits activation of MAP kinases in Arabidopsis.
Data indicate that MEKK2 is required for the mekk1, mkk1 mkk2, and mpk4 autoimmune phenotypes.
Title: Deletion of a tandem gene family in Arabidopsis: increased MEKK2 abundance triggers autoimmunity when the MEKK1-MKK1/2-MPK4 signaling cascade is disrupted.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

MASC_STS12345 (e-PCR)
- UniSTS:258533

NM_116917.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables MAP kinase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in regulation of defense response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to L-glutamate	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in root system development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: mitogen-activated protein kinase kinase kinase 9

NP_192588.1

mitogen-activated protein kinase kinase kinase 9 (MAPKKK9); FUNCTIONS IN: protein serine/threonine kinase activity, protein kinase activity, kinase activity, ATP binding; INVOLVED IN: protein amino acid phosphorylation; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Protein kinase, catalytic domain (InterPro:IPR000719), Serine/threonine-protein kinase domain (InterPro:IPR002290), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009); BEST Arabidopsis thaliana protein match is: MAPK/ERK kinase kinase 1 (TAIR:AT4G08500.1); Has 126354 Blast hits to 124684 proteins in 3992 species: Archae - 124; Bacteria - 13458; Metazoa - 47584; Fungi - 12553; Plants - 31595; Viruses - 535; Other Eukaryotes - 20505 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003075.7 Reference assembly

Range

5387351..5391575 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_116917.4 → NP_192588.1 mitogen-activated protein kinase kinase kinase 9 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_192588.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O81472

UniProtKB/TrEMBL

A0A654FME7

Conserved Domains (2) summary

smart00220
Location:501 → 755

S_TKc; Serine/Threonine protein kinases, catalytic domain

cl21453
Location:500 → 755

PKc_like; Protein Kinases, catalytic domain