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    ORC1B origin of replication complex 1B [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 826875, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ORC1B
    Official Full Name
    origin of replication complex 1B
    Primary source
    TAIR:AT4G12620
    Locus tag
    AT4G12620
    See related
    Araport:AT4G12620
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATORC1B; origin of replication complex 1B; T1P17.210; T1P17_210; UNE13; UNFERTILIZED EMBRYO SAC 13
    Summary
    Origin Recognition Complex subunit 1b. Involved in the initiation of DNA replication. Regulated transcriptionally during cell cycle, peaking at G1/S-phase. Target of E2F/DF family of transcription factors. Interacts with ORC2 and ORC5. Highly expressed in proliferating cells. Expression levels are independent of light regime.
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    Genomic context

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    See ORC1B in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    1
    Sequence:
    Chromosome: 4; NC_003075.7 (7459609..7462447, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene transcription initiation factor IIF subunit alpha RAP74 Neighboring gene B3 domain protein Neighboring gene RNA recognition motif (RRM)-containing protein Neighboring gene Endomembrane protein 70 protein family Neighboring gene Homeodomain-like superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structural Basis for the Unique Multivalent Readout of Unmodified H3 Tail by Arabidopsis ORC1b BAH-PHD Cassette. Li S, et al. Structure, 2016 Mar 1. PMID 26876097, Free PMC Article
    2. Distinct roles of Arabidopsis ORC1 proteins in DNA replication and heterochromatic H3K27me1 deposition. Vergara Z, et al. Nat Commun, 2023 Mar 7. PMID 36882445, Free PMC Article
    3. Arabidopsis ORC1 is a PHD-containing H3K4me3 effector that regulates transcription. de la Paz Sanchez M, et al. Proc Natl Acad Sci U S A, 2009 Feb 10. PMID 19171893, Free PMC Article
    4. The genes encoding Arabidopsis ORC subunits are E2F targets and the two ORC1 genes are differently expressed in proliferating and endoreplicating cells. Diaz-Trivino S, et al. Nucleic Acids Res, 2005. PMID 16179646, Free PMC Article
    5. ABAP1 is a novel plant Armadillo BTB protein involved in DNA replication and transcription. Masuda HP, et al. EMBO J, 2008 Oct 22. PMID 18818695, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Distinct roles of Arabidopsis ORC1 proteins in DNA replication and heterochromatic H3K27me1 deposition.
      Title: Distinct roles of Arabidopsis ORC1 proteins in DNA replication and heterochromatic H3K27me1 deposition.
    2. Study reports on the structure of Arabidopsis ORC1b BAH-PHD cassette in complex with an unmodified H3(1-15) peptide. The structural and biochemical data showed a unique multivalent readout of unmodified H3 tail at H3R2, H3K4, and H3T3, providing a potential link between plant DNA replication and epigenetic regulation.
      Title: Structural Basis for the Unique Multivalent Readout of Unmodified H3 Tail by Arabidopsis ORC1b BAH-PHD Cassette.
    3. ORC1a and ORC1b are regulated by the E2F/DP family of transcription factors and AtORC1b promoter is active exclusively in proliferating cells
      Title: The genes encoding Arabidopsis ORC subunits are E2F targets and the two ORC1 genes are differently expressed in proliferating and endoreplicating cells.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_117332.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chromatin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables double-stranded methylated DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA replication ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    acts_upstream_of_or_within double fertilization forming a zygote and endosperm IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    part_of origin recognition complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    origin of replication complex 1B
    NP_192999.1
    • origin of replication complex 1B (ORC1B); CONTAINS InterPro DOMAIN/s: ATPase, AAA-type, core (InterPro:IPR003959), Zinc finger, PHD-type, conserved site (InterPro:IPR019786), Zinc finger, PHD-type (InterPro:IPR001965), Origin recognition complex, subunit 1 (InterPro:IPR020793), ATPase, AAA+ type, core (InterPro:IPR003593), Bromo adjacent homology (BAH) domain (InterPro:IPR001025), Zinc finger, FYVE/PHD-type (InterPro:IPR011011), Zinc finger, PHD-finger (InterPro:IPR019787); BEST Arabidopsis thaliana protein match is: origin recognition complex 1 (TAIR:AT4G14700.1); Has 5914 Blast hits to 5512 proteins in 383 species: Archae - 477; Bacteria - 4; Metazoa - 3209; Fungi - 806; Plants - 927; Viruses - 0; Other Eukaryotes - 491 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      7459609..7462447 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_117332.3 → NP_192999.1  origin of replication complex 1B [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_192999.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9SU24
      UniProtKB/TrEMBL
      A0A178UTR9, A0A5S9XRP0, A0A654FNL7
      Conserved Domains (2) summary
      cd04718
      Location:189 → 344
      BAH_plant_2; BAH, or Bromo Adjacent Homology domain, plant-specific sub-family with unknown function. BAH domains are found in a variety of proteins playing roles in transcriptional silencing and the remodeling of chromatin. It is assumed that in most or all of these ...
      PTZ00112
      Location:424 → 727
      PTZ00112; origin recognition complex 1 protein; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SU24.1

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