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    CDC20.1 Transducin family protein / WD-40 repeat family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 829463, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CDC20.1
    Official Full Name
    Transducin family protein / WD-40 repeat family protein
    Primary source
    TAIR:AT4G33270
    Locus tag
    AT4G33270
    See related
    Araport:AT4G33270
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtCDC20.1; cell division cycle 20.1; F17M5.30; F17M5_30
    Summary
    Encodes a CDC20 protein that interacts with APC subunits, components of the mitochondrial checkpoint complex and mitotic cyclin substrates and is indispensable for normal plant development and fertility.
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    Genomic context

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    See CDC20.1 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    5
    Sequence:
    Chromosome: 4; NC_003075.7 (16044169..16046937, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 3K Neighboring gene Transducin family protein / WD-40 repeat family protein Neighboring gene AP2/B3-like transcriptional factor family protein Neighboring gene F-box and associated interaction domains-containing protein Neighboring gene ADR1-like 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis Cell Division Cycle 20.1 Is Required for Normal Meiotic Spindle Assembly and Chromosome Segregation. Niu B, et al. Plant Cell, 2015 Dec. PMID 26672070, Free PMC Article
    2. Centromeric cohesion is protected twice at meiosis, by SHUGOSHINs at anaphase I and by PATRONUS at interkinesis. Cromer L, et al. Curr Biol, 2013 Nov 4. PMID 24206843
    3. OSD1 promotes meiotic progression via APC/C inhibition and forms a regulatory network with TDM and CYCA1;2/TAM. Cromer L, et al. PLoS Genet, 2012. PMID 22844260, Free PMC Article
    4. GIGAS CELL1, a novel negative regulator of the anaphase-promoting complex/cyclosome, is required for proper mitotic progression and cell fate determination in Arabidopsis. Iwata E, et al. Plant Cell, 2011 Dec. PMID 22167058, Free PMC Article
    5. Specialization of CDC27 function in the Arabidopsis thaliana anaphase-promoting complex (APC/C). Pérez-Pérez JM, et al. Plant J, 2008 Jan. PMID 17944809

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CDC20.1 plays a critical role in spindle assembly checkpoint (SAC)-dependent meiotic chromosome segregation.
      Title: Arabidopsis Cell Division Cycle 20.1 Is Required for Normal Meiotic Spindle Assembly and Chromosome Segregation.
    2. conserved CDC20 functions could be assigned for AtCDC20.1 and AtCDC20.2
      Title: Conserved CDC20 cell cycle functions are carried out by two of the five isoforms in Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_119481.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables anaphase-promoting complex binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin-protein transferase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of mitotic checkpoint complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    Transducin family protein / WD-40 repeat family protein
    NP_195053.1
    • CDC20.1; CONTAINS InterPro DOMAIN/s: WD40 repeat 2 (InterPro:IPR019782), WD40 repeat-like-containing domain (InterPro:IPR011046), WD40 repeat, conserved site (InterPro:IPR019775), WD40-repeat-containing domain (InterPro:IPR017986), WD40/YVTN repeat-like-containing domain (InterPro:IPR015943), WD40 repeat (InterPro:IPR001680), WD40 repeat, subgroup (InterPro:IPR019781); BEST Arabidopsis thaliana protein match is: Transducin family protein / WD-40 repeat family protein (TAIR:AT4G33260.1); Has 49595 Blast hits to 24757 proteins in 709 species: Archae - 60; Bacteria - 7548; Metazoa - 19325; Fungi - 10981; Plants - 5978; Viruses - 0; Other Eukaryotes - 5703 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      16044169..16046937 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_119481.3 → NP_195053.1  Transducin family protein / WD-40 repeat family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_195053.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8GY38, Q9SQK2, Q9SZA4
      UniProtKB/TrEMBL
      A0A5S9XYM3, A0A654FV22
      Conserved Domains (2) summary
      COG2319
      Location:149 → 444
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:185 → 222
      7WD40; WD40 repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SZA4.1

    Gene LinkOut

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