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    MBD1 methyl-CPG-binding domain 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 828371, updated on 18-Sep-2024

    Summary

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    Official Symbol
    MBD1
    Official Full Name
    methyl-CPG-binding domain 1
    Primary source
    TAIR:AT4G22745
    Locus tag
    AT4G22745
    See related
    Araport:AT4G22745
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    methyl-CPG-binding domain 1
    Summary
    Protein containing methyl-CpG-binding domain.
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    Genomic context

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    See MBD1 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    3
    Sequence:
    Chromosome: 4; NC_003075.7 (11947210..11948804, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene Leucine-rich repeat protein kinase family protein Neighboring gene ncRNA Neighboring gene glycine-rich protein Neighboring gene DHHC-type zinc finger protein Neighboring gene methylsterol monooxygenase 1-3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Methylated DNA-binding proteins from Arabidopsis. Ito M, et al. Plant Physiol, 2003 Dec. PMID 14605234, Free PMC Article
    2. Characterization of Arabidopsis thaliana methyl-CpG-binding domain (MBD) proteins. Zemach A, et al. Plant J, 2003 Jun. PMID 12787239
    3. Arabidopsis RPD3-like histone deacetylases form multiple complexes involved in stress response. Feng C, et al. J Genet Genomics, 2021 May 20. PMID 34144927
    4. Extensive signal integration by the phytohormone protein network. Altmann M, et al. Nature, 2020 Jul. PMID 32612234
    5. CrY2H-seq: a massively multiplexed assay for deep-coverage interactome mapping. Wanamaker SA, et al. Nat Methods, 2017 Aug. PMID 28650476, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_118401.6

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    NOT enables cytosine C-5 DNA demethylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables methyl-CpG binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    part_of histone deacetylase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    methyl-CPG-binding domain 1
    NP_567667.2
    • methyl-CPG-binding domain 1 (MBD1); FUNCTIONS IN: methyl-CpG binding, DNA binding; INVOLVED IN: biological_process unknown; LOCATED IN: nucleus; CONTAINS InterPro DOMAIN/s: DNA-binding, integrase-type (InterPro:IPR016177), Methyl-CpG DNA binding (InterPro:IPR001739), Zinc finger, CW-type (InterPro:IPR011124); BEST Arabidopsis thaliana protein match is: methyl-CPG-binding domain 4 (TAIR:AT3G63030.1); Has 113 Blast hits to 113 proteins in 19 species: Archae - 0; Bacteria - 0; Metazoa - 4; Fungi - 0; Plants - 109; Viruses - 0; Other Eukaryotes - 0 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      11947210..11948804 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_118401.6 → NP_567667.2  methyl-CPG-binding domain 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_567667.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O49655, Q5XEN5
      UniProtKB/TrEMBL
      A0A178UWM3, A0A654FRX8
      Conserved Domains (2) summary
      cd01396
      Location:114 → 189
      MeCP2_MBD; MeCP2, MBD1, MBD2, MBD3, and MBD4 are members of a protein family that share the methyl-CpG-binding domain (MBD). The MBD, consists of about 70 residues and is defined as the minimal region required for binding to methylated DNA by a methyl-CpG-binding ...
      pfam07496
      Location:55 → 98
      zf-CW; CW-type Zinc Finger
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5XEN5.1

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