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    SAM-2 S-adenosylmethionine synthetase 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 826987, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SAM-2
    Official Full Name
    S-adenosylmethionine synthetase 2
    Primary source
    TAIR:AT4G01850
    Locus tag
    AT4G01850
    See related
    Araport:AT4G01850
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtSAM2; MAT2; S-adenosylmethionine synthetase 2; S-ADENOSYLMETHIONINE SYNTHETASE 2; SAM2; T7B11.11; T7B11_11
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    Genomic context

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    See SAM-2 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    2
    Sequence:
    Chromosome: 4; NC_003075.7 (795986..798381, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene P-glycoprotein 5 Neighboring gene Ca2+ activated outward rectifying K+ channel 5 Neighboring gene Transducin family protein / WD-40 repeat family protein Neighboring gene tRNA-Phe

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. FERONIA receptor kinase interacts with S-adenosylmethionine synthetase and suppresses S-adenosylmethionine production and ethylene biosynthesis in Arabidopsis. Mao D, et al. Plant Cell Environ, 2015 Dec. PMID 25988356
    2. EXPO, an exocyst-positive organelle distinct from multivesicular endosomes and autophagosomes, mediates cytosol to cell wall exocytosis in Arabidopsis and tobacco cells. Wang J, et al. Plant Cell, 2010 Dec. PMID 21193573, Free PMC Article
    3. Proteomic survey of copper-binding proteins in Arabidopsis roots by immobilized metal affinity chromatography and mass spectrometry. Kung CC, et al. Proteomics, 2006 May. PMID 16526091
    4. Tandem affinity purification and mass spectrometric analysis of ubiquitylated proteins in Arabidopsis. Saracco SA, et al. Plant J, 2009 Jul. PMID 19292762, Free PMC Article
    5. Profiling of the Receptor for Activated C Kinase 1a (RACK1a) interaction network in Arabidopsis thaliana. Guo J, et al. Biochem Biophys Res Commun, 2019 Dec 3. PMID 31606202

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001084876.1
    NM_116415.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables copper ion binding HDA PubMed 
    enables methionine adenosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in S-adenosylmethionine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol HDA PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT located_in cytosol RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    located_in extracellular exosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus HDA PubMed 
    located_in plant-type cell wall HDA PubMed 
    located_in plasmodesma HDA PubMed 

    General protein information

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    Preferred Names
    S-adenosylmethionine synthetase 2
    NP_001078345.1
    • S-adenosylmethionine synthetase 2 (SAM-2); FUNCTIONS IN: methionine adenosyltransferase activity; INVOLVED IN: one-carbon metabolic process, S-adenosylmethionine biosynthetic process; EXPRESSED IN: 27 plant structures; EXPRESSED DURING: 16 growth stages; CONTAINS InterPro DOMAIN/s: S-adenosylmethionine synthetase (InterPro:IPR002133), S-adenosylmethionine synthetase superfamily (InterPro:IPR022636), S-adenosylmethionine synthetase, N-terminal (InterPro:IPR022628), S-adenosylmethionine synthetase, C-terminal (InterPro:IPR022630), S-adenosylmethionine synthetase, conserved site (InterPro:IPR022631), S-adenosylmethionine synthetase, central domain (InterPro:IPR022629); BEST Arabidopsis thaliana protein match is: S-adenosylmethionine synthetase 1 (TAIR:AT1G02500.2); Has 10906 Blast hits to 10898 proteins in 2898 species: Archae - 12; Bacteria - 5497; Metazoa - 373; Fungi - 167; Plants - 706; Viruses - 1; Other Eukaryotes - 4150 (source: NCBI BLink).
    NP_192094.1
    • S-adenosylmethionine synthetase 2 (SAM-2); FUNCTIONS IN: copper ion binding, methionine adenosyltransferase activity; INVOLVED IN: one-carbon metabolic process, S-adenosylmethionine biosynthetic process; LOCATED IN: nucleolus, cell wall; EXPRESSED IN: 27 plant structures; EXPRESSED DURING: 17 growth stages; CONTAINS InterPro DOMAIN/s: S-adenosylmethionine synthetase (InterPro:IPR002133), S-adenosylmethionine synthetase superfamily (InterPro:IPR022636), S-adenosylmethionine synthetase, N-terminal (InterPro:IPR022628), S-adenosylmethionine synthetase, C-terminal (InterPro:IPR022630), S-adenosylmethionine synthetase, conserved site (InterPro:IPR022631), S-adenosylmethionine synthetase, central domain (InterPro:IPR022629); BEST Arabidopsis thaliana protein match is: S-adenosylmethionine synthetase 1 (TAIR:AT1G02500.2); Has 10906 Blast hits to 10898 proteins in 2898 species: Archae - 12; Bacteria - 5497; Metazoa - 373; Fungi - 167; Plants - 706; Viruses - 1; Other Eukaryotes - 4150 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      795986..798381 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_116415.4 → NP_192094.1  S-adenosylmethionine synthetase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_192094.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P17562, Q42263
      UniProtKB/TrEMBL
      A0A178V3V9, A0A5S9XP07
      Conserved Domains (1) summary
      PLN02243
      Location:1 → 386
      PLN02243; S-adenosylmethionine synthase

    2. NM_001084876.1 → NP_001078345.1  S-adenosylmethionine synthetase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001078345.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P17562, Q42263
      UniProtKB/TrEMBL
      A0A178V3V9, A0A5S9XP07
      Conserved Domains (1) summary
      PLN02243
      Location:1 → 386
      PLN02243; S-adenosylmethionine synthase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P17562.1

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