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    ENDO4 endonuclease 4 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 828244, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ENDO4
    Official Full Name
    endonuclease 4
    Primary source
    TAIR:AT4G21585
    Locus tag
    AT4G21585
    See related
    Araport:AT4G21585
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    endonuclease 4
    Summary
    Encodes a putative endonuclease but no demonstrable endonuclease activity, either towards single stranded DNA or mismatches, has been seen in vitro.
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    Genomic context

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    See ENDO4 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    7
    Sequence:
    Chromosome: 4; NC_003075.7 (11477814..11480179)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene VP1/ABI3-like 3 Neighboring gene vacuolar protein sorting-associated protein-like protein Neighboring gene organic solute transporter ostalpha protein (DUF300) Neighboring gene oxidoreductase, zinc-binding dehydrogenase family protein Neighboring gene endonuclease 3 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The plant s1-like nuclease family has evolved a highly diverse range of catalytic capabilities. Lesniewicz K, et al. Plant Cell Physiol, 2013 Jul. PMID 23620482
    2. Characterization of Arabidopsis thaliana mismatch specific endonucleases: application to mutation discovery by TILLING in pea. Triques K, et al. Plant J, 2007 Sep. PMID 17651368
    3. Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana. Mayer K, et al. Nature, 1999 Dec 16. PMID 10617198

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data indicate that five S1-like nucleases have been named as ENDO1 (BFN1, AT1G11190), ENDO2 (AT1G68290), ENDO3 (AT4G21590), ENDO4 (AT4G21585) and ENDO5 (AT4G21600).
      Title: The plant s1-like nuclease family has evolved a highly diverse range of catalytic capabilities.
    2. ENDO4 is a Ca2+-dependent and Zn2+-sensitive nuclease active at neutral pH
      Title: The plant s1-like nuclease family has evolved a highly diverse range of catalytic capabilities.
    Submit: New GeneRIF Correction

    General gene information

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    NM_001341502.1
    NM_001341503.1
    NM_001341504.1
    NM_001341505.1
    NM_148368.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables RNA endonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT enables T/G mismatch-specific endonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables endonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT enables single-stranded DNA endodeoxyribonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables single-stranded DNA endodeoxyribonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    endonuclease 4
    NP_680734.1
    • endonuclease 4 (ENDO4); FUNCTIONS IN: endonuclease activity, nucleic acid binding; INVOLVED IN: DNA catabolic process; LOCATED IN: endomembrane system; CONTAINS InterPro DOMAIN/s: Phospholipase C/P1 nuclease, core (InterPro:IPR008947), S1/P1 nuclease (InterPro:IPR003154); BEST Arabidopsis thaliana protein match is: endonuclease 5 (TAIR:AT4G21600.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      11477814..11480179
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001341501.1 → NP_001328108.1  endonuclease 4 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UV58, A0A1P8B3N0

    2. NM_148368.2 → NP_680734.1  endonuclease 4 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_680734.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4JJL0
      UniProtKB/TrEMBL
      A0A5S9XUZ3, A0A654FRG3
      Conserved Domains (1) summary
      pfam02265
      Location:25 → 291
      S1-P1_nuclease; S1/P1 Nuclease

    3. NM_001341502.1 → NP_001328109.1  endonuclease 4 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B3M9, A0A5S9XUZ3

    4. NM_001341503.1 → NP_001328107.1  endonuclease 4 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4JJL0
      UniProtKB/TrEMBL
      A0A5S9XUZ3, A0A654FRG3
      Conserved Domains (1) summary
      pfam02265
      Location:25 → 291
      S1-P1_nuclease; S1/P1 Nuclease

    5. NM_001341504.1 → NP_001328110.1  endonuclease 4 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UV58, A0A1P8B3N0

    6. NM_001341505.1 → NP_001328111.1  endonuclease 4 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B3Q3, A0A5S9XUZ3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F4JJL0.1

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