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    ECA2 ER-type Ca2+-ATPase 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 827984, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ECA2
    Official Full Name
    ER-type Ca2+-ATPase 2
    Primary source
    TAIR:AT4G00900
    Locus tag
    AT4G00900
    See related
    Araport:AT4G00900
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS THALIANA ER-TYPE CA2+-ATPASE 2; ATECA2; A_TM018A10.4; A_TM018A10_4; ER-type Ca2+-ATPase 2; T18A10.20; T18A10_20
    Summary
    Type IIA (SERCA-type) Ca2+ ATPase, catalyzes the efflux of calcium from the cytoplasm.
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    Genomic context

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    See ECA2 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    6
    Sequence:
    Chromosome: 4; NC_003075.7 (382663..386850, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene F-box/kelch-repeat protein Neighboring gene ATPase, F1 complex, OSCP/delta subunit protein Neighboring gene aluminum activated malate transporter family protein Neighboring gene NC domain-containing protein-like protein Neighboring gene COP1-interacting protein-like protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genomic comparison of P-type ATPase ion pumps in Arabidopsis and rice. Baxter I, et al. Plant Physiol, 2003 Jun. PMID 12805592, Free PMC Article
    2. Uncovering Arabidopsis membrane protein interactome enriched in transporters using mating-based split ubiquitin assays and classification models. Chen J, et al. Front Plant Sci, 2012. PMID 22737156, Free PMC Article
    3. Two additional type IIA Ca(2+)-ATPases are expressed in Arabidopsis thaliana: evidence that type IIA sub-groups exist. Pittman JK, et al. Gene, 1999 Aug 5. PMID 10433975
    4. 14-3-3 proteins fine-tune plant nutrient metabolism. Shin R, et al. FEBS Lett, 2011 Jan 3. PMID 21094157
    5. Putative glycosyltransferases and other plant Golgi apparatus proteins are revealed by LOPIT proteomics. Nikolovski N, et al. Plant Physiol, 2012 Oct. PMID 22923678, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001340276.1
    NM_116317.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables P-type calcium transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within calcium ion transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 

    General protein information

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    Preferred Names
    ER-type Ca2+-ATPase 2
    NP_191999.1
    • ER-type Ca2+-ATPase 2 (ECA2); FUNCTIONS IN: calcium-transporting ATPase activity; INVOLVED IN: calcium ion transport; LOCATED IN: integral to membrane, membrane; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: ATPase, P-type, ATPase-associated domain (InterPro:IPR008250), ATPase, P-type, calcium-transporting (InterPro:IPR005782), ATPase, P-type cation-transporter, N-terminal (InterPro:IPR004014), ATPase, P-type cation exchange, alpha subunit (InterPro:IPR006069), Haloacid dehalogenase-like hydrolase (InterPro:IPR005834), ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter (InterPro:IPR001757), ATPase, P-type phosphorylation site (InterPro:IPR018303), ATPase, P-type cation-transporter, C-terminal (InterPro:IPR006068); BEST Arabidopsis thaliana protein match is: ER-type Ca2+-ATPase 1 (TAIR:AT1G07810.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      382663..386850 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_116317.4 → NP_191999.1  ER-type Ca2+-ATPase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_191999.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O23087
      UniProtKB/TrEMBL
      A0A178UYB0
      Conserved Domains (7) summary
      COG4087
      Location:698 → 762
      COG4087; Soluble P-type ATPase [General function prediction only]
      TIGR01116
      Location:58 → 1041
      ATPase-IIA1_Ca; sarco/endoplasmic reticulum calcium-translocating P-type ATPase
      pfam00122
      Location:101 → 357
      E1-E2_ATPase; E1-E2 ATPase
      pfam00689
      Location:812 → 1039
      Cation_ATPase_C; Cation transporting ATPase, C-terminus
      pfam00690
      Location:9 → 77
      Cation_ATPase_N; Cation transporter/ATPase, N-terminus
      pfam13246
      Location:432 → 541
      Cation_ATPase; Cation transport ATPase (P-type)
      cl23717
      Location:615 → 704
      crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...

    2. NM_001340276.1 → NP_001329712.1  ER-type Ca2+-ATPase 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O23087
      UniProtKB/TrEMBL
      A0A178UYB0
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O23087.1

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