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    Elf2 E74 like ETS transcription factor 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361944, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Elf2provided by RGD
    Official Full Name
    E74 like ETS transcription factor 2provided by RGD
    Primary source
    RGD:1310585
    See related
    EnsemblRapid:ENSRNOG00000010815 AllianceGenome:RGD:1310585
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and sequence-specific double-stranded DNA binding activity. Predicted to be involved in negative regulation of DNA-templated transcription; positive regulation of DNA-templated transcription; and regulation of transcription by RNA polymerase II. Predicted to be located in cytosol and nuclear body. Orthologous to human ELF2 (E74 like ETS transcription factor 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 97.0), Testes (RPKM 91.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Elf2 in Genome Data Viewer
    Location:
    2q26
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (137445787..137536512, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (135292291..135385942, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (140310374..140399312, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134485733 Neighboring gene nocturnin Neighboring gene transfer RNA proline (anticodon UGG) 2 Neighboring gene transfer RNA proline (anticodon AGG) 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Colocalization of oxytocin and phosphorylated form of elongation factor 2 in the rat hypothalamus. Fujisawa T, et al. Acta Med Okayama, 2007 Jun. PMID 17593952
    2. Post-transcriptional effects and interactions between chronic mild stress and acute sleep deprivation: regulation of translation factor and cytoplasmic polyadenylation element-binding protein phosphorylation. Grønli J, et al. Behav Brain Res, 2012 Dec 1. PMID 22917528
    3. Characterization of NERF, a novel transcription factor related to the Ets factor ELF-1. Oettgen P, et al. Mol Cell Biol, 1996 Sep. PMID 8756667, Free PMC Article
    4. Isoforms of the Ets transcription factor NERF/ELF-2 physically interact with AML1 and mediate opposing effects on AML1-mediated transcription of the B cell-specific blk gene. Cho JY, et al. J Biol Chem, 2004 May 7. PMID 14970218
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The eEF2 phosphorylation was elevated in all brain regions after sleep deprivation
      Title: Post-transcriptional effects and interactions between chronic mild stress and acute sleep deprivation: regulation of translation factor and cytoplasmic polyadenylation element-binding protein phosphorylation.
    2. Oxt is colocalized with the phosphorylated form of Elf2 in the hypothalamus.
      Title: Colocalization of oxytocin and phosphorylated form of elongation factor 2 in the rat hypothalamus.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ETS-related transcription factor Elf-2
    Names
    E74-like factor 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012181.2 → NP_001012181.1  ETS-related transcription factor Elf-2 isoform 2

      See identical proteins and their annotated locations for NP_001012181.1

      Status: VALIDATED

      Source sequence(s)
      BC083585, BC083598, JAXUCZ010000002
      UniProtKB/TrEMBL
      A0A8I6AGL8, A0A9K3Y6V8, G3V7H5, Q5XIS3
      Related
      ENSRNOP00000086563.1, ENSRNOT00000102166.2
      Conserved Domains (2) summary
      pfam00178
      Location:138 → 217
      Ets; Ets-domain
      pfam12310
      Location:20 → 48
      Elf-1_N; Transcription factor protein N terminal

    2. NM_001033909.1 → NP_001029081.1  ETS-related transcription factor Elf-2 isoform 1

      See identical proteins and their annotated locations for NP_001029081.1

      Status: VALIDATED

      Source sequence(s)
      BC083585
      UniProtKB/TrEMBL
      A0A8I6AGL8, A6JV53, F7FA98, Q5XIT5
      Conserved Domains (3) summary
      pfam05109
      Location:349 → 528
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam00178
      Location:209 → 289
      Ets; Ets-domain
      pfam12310
      Location:3 → 108
      Elf-1_N; Transcription factor protein N terminal

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      137445787..137536512 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063282069.1 → XP_063138139.1  ETS-related transcription factor Elf-2 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AGL8

    2. XM_006232325.5 → XP_006232387.1  ETS-related transcription factor Elf-2 isoform X1

      See identical proteins and their annotated locations for XP_006232387.1

      UniProtKB/TrEMBL
      A0A8I6AGL8, A6JV53, F7FA98, Q5XIT5
      Conserved Domains (3) summary
      pfam05109
      Location:349 → 528
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam00178
      Location:209 → 289
      Ets; Ets-domain
      pfam12310
      Location:3 → 108
      Elf-1_N; Transcription factor protein N terminal

    3. XM_063282068.1 → XP_063138138.1  ETS-related transcription factor Elf-2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AGL8, A6JV53, F7FA98, Q5XIT5

    4. XM_063282070.1 → XP_063138140.1  ETS-related transcription factor Elf-2 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AGL8

    5. XM_006232329.4 → XP_006232391.1  ETS-related transcription factor Elf-2 isoform X5

      UniProtKB/TrEMBL
      A0A8I6AGL8
      Related
      ENSRNOP00000090124.2, ENSRNOT00000110678.2
      Conserved Domains (1) summary
      pfam00178
      Location:94 → 173
      Ets; Ets-domain

    6. XM_006232328.4 → XP_006232390.1  ETS-related transcription factor Elf-2 isoform X4

      UniProtKB/TrEMBL
      A0A8I6AGL8
      Conserved Domains (1) summary
      pfam00178
      Location:106 → 185
      Ets; Ets-domain

    7. XM_039102601.2 → XP_038958529.1  ETS-related transcription factor Elf-2 isoform X6

      UniProtKB/TrEMBL
      A0A8I6AGL8
      Conserved Domains (2) summary
      pfam05109
      Location:214 → 393
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam00178
      Location:74 → 154
      Ets; Ets-domain

    8. XM_039102600.2 → XP_038958528.1  ETS-related transcription factor Elf-2 isoform X6

      UniProtKB/TrEMBL
      A0A8I6AGL8
      Conserved Domains (2) summary
      pfam05109
      Location:214 → 393
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam00178
      Location:74 → 154
      Ets; Ets-domain

    9. XM_006232327.5 → XP_006232389.1  ETS-related transcription factor Elf-2 isoform X3

      See identical proteins and their annotated locations for XP_006232389.1

      UniProtKB/TrEMBL
      A0A8I6A6H4, A6JV55
      Related
      ENSRNOP00000015067.6, ENSRNOT00000015067.9
      Conserved Domains (2) summary
      pfam00178
      Location:150 → 229
      Ets; Ets-domain
      pfam12310
      Location:20 → 48
      Elf-1_N; Transcription factor protein N terminal
    Nucleotide Protein Strain
    Heading Accession and Version

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