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    Cobll1 cordon-bleu WH2 repeat protein-like 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 311088, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cobll1provided by RGD
    Official Full Name
    cordon-bleu WH2 repeat protein-like 1provided by RGD
    Primary source
    RGD:1308954
    See related
    EnsemblRapid:ENSRNOG00000027016 AllianceGenome:RGD:1308954
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable actin monomer binding activity. Orthologous to human COBLL1 (cordon-bleu WH2 repeat protein like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 210.4), Kidney (RPKM 65.5) and 6 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cobll1 in Genome Data Viewer
    Location:
    3q21
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (70161369..70324844, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (49753260..49915168, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (51137104..51298956, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene growth factor receptor bound protein 14 Neighboring gene U4 spliceosomal RNA Neighboring gene uncharacterized LOC100911508 Neighboring gene uncharacterized LOC120101557 Neighboring gene U7 small nuclear RNA Neighboring gene ribosomal protein S11, pseudogene 10 Neighboring gene uncharacterized LOC134486367 Neighboring gene solute carrier family 38, member 11

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Long non-coding RNA NORAD aggravates acute myocardial infarction by promoting fibrosis and apoptosis via miR-577/COBLL1 axis. Xiong X, et al. Environ Toxicol, 2021 Nov. PMID 34355838
    2. E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Guo Z, et al. Sci Signal, 2014 Dec 2. PMID 25468996, Free PMC Article
    3. Large-scale proteomics and phosphoproteomics of urinary exosomes. Gonzales PA, et al. J Am Soc Nephrol, 2009 Feb. PMID 19056867, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Long non-coding RNA NORAD aggravates acute myocardial infarction by promoting fibrosis and apoptosis via miR-577/COBLL1 axis.
      Title: Long non-coding RNA NORAD aggravates acute myocardial infarction by promoting fibrosis and apoptosis via miR-577/COBLL1 axis.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actin monomer binding IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cordon-bleu protein-like 1
    Names
    Cobl-like 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427223.1 → NP_001414152.1  cordon-bleu protein-like 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      Related
      ENSRNOP00000078543.2, ENSRNOT00000104492.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      70161369..70324844 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063283623.1 → XP_063139693.1  cordon-bleu protein-like 1 isoform X11

    2. XM_006234304.5 → XP_006234366.1  cordon-bleu protein-like 1 isoform X10

      UniProtKB/TrEMBL
      A0A8I5ZL13
      Conserved Domains (2) summary
      pfam09469
      Location:176 → 254
      Cobl; Cordon-bleu ubiquitin-like domain
      cl00155
      Location:92 → 161
      UBQ; Ubiquitin-like proteins

    3. XM_039106330.2 → XP_038962258.1  cordon-bleu protein-like 1 isoform X6

      Conserved Domains (5) summary
      PHA03247
      Location:887 → 1162
      PHA03247; large tegument protein UL36; Provisional
      pfam09469
      Location:176 → 254
      Cobl; Cordon-bleu ubiquitin-like domain
      cd21762
      Location:1274 → 1277
      WH2; actin-binding sequence [structural motif]
      cl28922
      Location:92 → 156
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
      cl41728
      Location:1253 → 1278
      WH2; Wiskott-Aldrich Syndrome Homology (WASP) region 2 (WH2 motif), and similar proteins

    4. XM_039106333.2 → XP_038962261.1  cordon-bleu protein-like 1 isoform X9

      Conserved Domains (5) summary
      PHA03247
      Location:860 → 1135
      PHA03247; large tegument protein UL36; Provisional
      pfam09469
      Location:176 → 252
      Cobl; Cordon-bleu ubiquitin-like domain
      cd21762
      Location:1247 → 1250
      WH2; actin-binding sequence [structural motif]
      cl28922
      Location:92 → 156
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
      cl41728
      Location:1226 → 1251
      WH2; Wiskott-Aldrich Syndrome Homology (WASP) region 2 (WH2 motif), and similar proteins

    5. XM_039106332.2 → XP_038962260.1  cordon-bleu protein-like 1 isoform X7

      UniProtKB/TrEMBL
      F1M124
      Related
      ENSRNOP00000001607.7, ENSRNOT00000001607.8
      Conserved Domains (5) summary
      PHA03247
      Location:865 → 1140
      PHA03247; large tegument protein UL36; Provisional
      pfam09469
      Location:176 → 252
      Cobl; Cordon-bleu ubiquitin-like domain
      cd21762
      Location:1252 → 1255
      WH2; actin-binding sequence [structural motif]
      cl28922
      Location:92 → 156
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
      cl41728
      Location:1231 → 1256
      WH2; Wiskott-Aldrich Syndrome Homology (WASP) region 2 (WH2 motif), and similar proteins

    6. XM_039106329.2 → XP_038962257.1  cordon-bleu protein-like 1 isoform X3

      Conserved Domains (5) summary
      PHA03247
      Location:900 → 1175
      PHA03247; large tegument protein UL36; Provisional
      pfam09469
      Location:176 → 252
      Cobl; Cordon-bleu ubiquitin-like domain
      cd21762
      Location:1287 → 1290
      WH2; actin-binding sequence [structural motif]
      cl28922
      Location:92 → 156
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
      cl41728
      Location:1266 → 1291
      WH2; Wiskott-Aldrich Syndrome Homology (WASP) region 2 (WH2 motif), and similar proteins

    7. XM_063283618.1 → XP_063139688.1  cordon-bleu protein-like 1 isoform X2

    8. XM_063283621.1 → XP_063139691.1  cordon-bleu protein-like 1 isoform X5

    9. XM_063283619.1 → XP_063139689.1  cordon-bleu protein-like 1 isoform X4

      Related
      ENSRNOP00000110145.1, ENSRNOT00000156132.1

    10. XM_063283617.1 → XP_063139687.1  cordon-bleu protein-like 1 isoform X1

    11. XM_039106337.2 → XP_038962265.1  cordon-bleu protein-like 1 isoform X12

      Conserved Domains (5) summary
      PHA03247
      Location:841 → 1116
      PHA03247; large tegument protein UL36; Provisional
      pfam09469
      Location:117 → 193
      Cobl; Cordon-bleu ubiquitin-like domain
      cd21762
      Location:1228 → 1231
      WH2; actin-binding sequence [structural motif]
      cl28922
      Location:33 → 97
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
      cl41728
      Location:1207 → 1232
      WH2; Wiskott-Aldrich Syndrome Homology (WASP) region 2 (WH2 motif), and similar proteins

    12. XM_063283622.1 → XP_063139692.1  cordon-bleu protein-like 1 isoform X8

      Related
      ENSRNOP00000109352.1, ENSRNOT00000133172.1

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001107733.1: Suppressed sequence

      Description
      NM_001107733.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from human: COBLL1 (GeneID:22837).
    Nucleotide Protein Strain
    Heading Accession and Version

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