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    BTS zinc finger protein-like protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 821357, updated on 18-Sep-2024

    Summary

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    Official Symbol
    BTS
    Official Full Name
    zinc finger protein-like protein
    Primary source
    TAIR:AT3G18290
    Locus tag
    AT3G18290
    See related
    Araport:AT3G18290
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    BRUTUS; EMB2454; embryo defective 2454
    Summary
    Encodes BRUTUS (BTS), a putative E3 ligase protein with metal ion binding and DNA binding domains, which negatively regulates the response to iron deficiency.
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    Genomic context

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    See BTS in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    14
    Sequence:
    Chromosome: 3; NC_003074.8 (6273966..6280562)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin superfamily protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene DUF1639 family protein, putative (DUF1639) Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Bacterial effector targeting of a plant iron sensor facilitates iron acquisition and pathogen colonization. Xing Y, et al. Plant Cell, 2021 Jul 19. PMID 33751120, Free PMC Article
    2. Knockdown of BTS may provide a new strategy to improve cadmium-phytoremediation efficiency by improving iron status in plants. Zhu YX, et al. J Hazard Mater, 2020 Feb 15. PMID 31676164
    3. The E3 ligase BRUTUS facilitates degradation of VOZ1/2 transcription factors. Selote D, et al. Plant Cell Environ, 2018 Oct. PMID 29878379
    4. ELONGATED HYPOCOTYL 5 regulates BRUTUS and affects iron acquisition and homeostasis in Arabidopsis thaliana. Mankotia S, et al. Plant J, 2023 Jun. PMID 36920240
    5. BRUTUS and its paralogs, BTS LIKE1 and BTS LIKE2, encode important negative regulators of the iron deficiency response in Arabidopsis thaliana. Hindt MN, et al. Metallomics, 2017 Jul 19. PMID 28620661, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ELONGATED HYPOCOTYL 5 regulates BRUTUS and affects iron acquisition and homeostasis in Arabidopsis thaliana.
      Title: ELONGATED HYPOCOTYL 5 regulates BRUTUS and affects iron acquisition and homeostasis in Arabidopsis thaliana.
    2. Bacterial effector targeting of a plant iron sensor facilitates iron acquisition and pathogen colonization.
      Title: Bacterial effector targeting of a plant iron sensor facilitates iron acquisition and pathogen colonization.
    3. Knockdown of BTS may provide a new strategy to improve cadmium-phytoremediation efficiency by improving iron status in plants.
      Title: Knockdown of BTS may provide a new strategy to improve cadmium-phytoremediation efficiency by improving iron status in plants.
    4. facilitates degradation of VOZ1/2 transcription factors
      Title: The E3 ligase BRUTUS facilitates degradation of VOZ1/2 transcription factors.
    5. the two A. thaliana BTS paralogs, BTS LIKE1 (BTSL1) and BTS LIKE2 (BTSL2) encode proteins that act redundantly as negative regulators of the Fe deficiency response.
      Title: BRUTUS and its paralogs, BTS LIKE1 and BTS LIKE2, encode important negative regulators of the iron deficiency response in Arabidopsis thaliana.
    6. mediates iron response by targeting basic helix-loop-helix transcription factors
      Title: Iron-binding E3 ligase mediates iron response in plants by targeting basic helix-loop-helix transcription factors.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_112713.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables iron ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to hypoxia HEP PubMed 
    acts_upstream_of_or_within cellular response to iron ion starvation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in cellular response to iron ion starvation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in cellular response to iron ion starvation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within embryo development ending in seed dormancy NAS
    Non-traceable Author Statement
    more info
    		  
    involved_in multicellular organismal-level iron ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein-like protein
    NP_188457.1
    • BRUTUS (BTS); FUNCTIONS IN: zinc ion binding; INVOLVED IN: cellular response to iron ion starvation, embryo development ending in seed dormancy; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Zinc finger, CTCHY-type (InterPro:IPR017921), Zinc finger, CHY-type (InterPro:IPR008913), Zinc finger, RING-type (InterPro:IPR001841), Haemerythrin/HHE cation-binding motif (InterPro:IPR012312); BEST Arabidopsis thaliana protein match is: zinc ion binding (TAIR:AT1G74770.1); Has 1787 Blast hits to 1677 proteins in 200 species: Archae - 0; Bacteria - 15; Metazoa - 641; Fungi - 164; Plants - 725; Viruses - 2; Other Eukaryotes - 240 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      6273966..6280562
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_112713.4 → NP_188457.1  zinc finger protein-like protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_188457.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0WL18, Q8LPQ5, Q9LJQ1
      UniProtKB/TrEMBL
      A0A178V605, A0A654F8D7
      Conserved Domains (4) summary
      cd12108
      Location:57 → 183
      Hr-like; Hemerythrin-like domain
      cd16464
      Location:1134 → 1176
      RING-H2_Pirh2; RING finger, H2 subclass, found in p53-induced RING-H2 protein (Pirh2) and similar proteins
      pfam05495
      Location:1006 → 1082
      zf-CHY; CHY zinc finger
      pfam14599
      Location:1181 → 1239
      zinc_ribbon_6; Zinc-ribbon
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8LPQ5.1

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