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    WOX5 WUSCHEL related homeobox 5 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 820297, updated on 18-Sep-2024

    Summary

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    Official Symbol
    WOX5
    Official Full Name
    WUSCHEL related homeobox 5
    Primary source
    TAIR:AT3G11260
    Locus tag
    AT3G11260
    See related
    Araport:AT3G11260
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    WOX5B; WUSCHEL related homeobox 5; WUSCHEL related homeobox 5B
    Summary
    Arabidopsis thaliana WOX5 protein mRNA
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    Genomic context

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    See WOX5 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    2
    Sequence:
    Chromosome: 3; NC_003074.8 (3527280..3528440)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene Yippee family putative zinc-binding protein Neighboring gene arginine-tRNA protein transferase 2 Neighboring gene Ribosomal protein L10 family protein Neighboring gene Mov34/MPN/PAD-1 family protein Neighboring gene Duplicated homeodomain-like superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Overexpression of Liriodenron WOX5 in Arabidopsis Leads to Ectopic Flower Formation and Altered Root Morphology. Wang D, et al. Int J Mol Sci, 2023 Jan 4. PMID 36674428, Free PMC Article
    2. A turanose-insensitive mutant suggests a role for WOX5 in auxin homeostasis in Arabidopsis thaliana. Gonzali S, et al. Plant J, 2005 Nov. PMID 16262712
    3. Induction of auxin biosynthesis and WOX5 repression mediate changes in root development in Arabidopsis exposed to chitosan. Lopez-Moya F, et al. Sci Rep, 2017 Dec 1. PMID 29196703, Free PMC Article
    4. WOX5 is Shining in the Root Stem Cell Niche. Kong X, et al. Trends Plant Sci, 2015 Oct. PMID 26440429
    5. Mathematical modelling of WOX5- and CLE40-mediated columella stem cell homeostasis in Arabidopsis. Richards S, et al. J Exp Bot, 2015 Aug. PMID 26019259, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. WUSCHEL RELATED HOMEOBOX5 and 7 maintain callus development by promoting cell division in Arabidopsis.
      Title: WUSCHEL RELATED HOMEOBOX5 and 7 maintain callus development by promoting cell division in Arabidopsis.
    2. Overexpression of Liriodenron WOX5 in Arabidopsis Leads to Ectopic Flower Formation and Altered Root Morphology.
      Title: Overexpression of Liriodenron WOX5 in Arabidopsis Leads to Ectopic Flower Formation and Altered Root Morphology.
    3. Post-Embryonic Lateral Organ Development and Adaxial-Abaxial Polarity Are Regulated by the Combined Effect of ENHANCER OF SHOOT REGENERATION 1 and WUSCHEL in Arabidopsis Shoots.
      Title: Post-Embryonic Lateral Organ Development and Adaxial-Abaxial Polarity Are Regulated by the Combined Effect of ENHANCER OF SHOOT REGENERATION 1 and WUSCHEL in Arabidopsis Shoots.
    4. Salicylic acid promotes quiescent center cell division through ROS accumulation and down-regulation of PLT1, PLT2, and WOX5.
      Title: Salicylic acid promotes quiescent center cell division through ROS accumulation and down-regulation of PLT1, PLT2, and WOX5.
    5. WUSCHEL-RELATED HOMEOBOX 5 (WOX5) is ectopically expressed in vascular cells in embryos with serk1 serk2 bak1 mutattions. The first transverse division of vascular precursors in mid-globular embryos and second asymmetric division of ground tissue stem cells in early-heart embryos are abnormally altered to a longitudinal division.
      Title: SERK Receptor-like Kinases Control Division Patterns of Vascular Precursors and Ground Tissue Stem Cells during Embryo Development in Arabidopsis.
    6. Results show that high doses of chitosan reduce WOX5 expression in the root apical meristem and arrest root growth.
      Title: Induction of auxin biosynthesis and WOX5 repression mediate changes in root development in Arabidopsis exposed to chitosan.
    7. the expression switch from WOX11/12 to WOX5/7 is critical for initiation of the root primordium during de novo root organogenesis.
      Title: Transcription Factors WOX11/12 Directly Activate WOX5/7 to Promote Root Primordia Initiation and Organogenesis.
    8. WOX5 plays a role in root stem cell niche maintenance.
      Title: WOX5 is Shining in the Root Stem Cell Niche.
    9. WOX5 signals from the quiescent centre to promote columella stem cell (CSC) fate, while CLE40 is secreted from the differentiated columella cells to promote differentiation.
      Title: Mathematical modelling of WOX5- and CLE40-mediated columella stem cell homeostasis in Arabidopsis.
    10. ROW1 is essential for quiescent centre maintenance and for stem cell niche development through the repression of WOX5 in the proximal meristem.
      Title: ROW1 maintains quiescent centre identity by confining WOX5 expression to specific cells.
    Submit: New GeneRIF Correction See all GeneRIFs (16)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_111961.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific DNA binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in maintenance of root meristem identity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to auxin IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    WUSCHEL related homeobox 5
    NP_187735.2
    • WUSCHEL related homeobox 5 (WOX5); CONTAINS InterPro DOMAIN/s: Homeobox (InterPro:IPR001356), Homeodomain-like (InterPro:IPR009057); BEST Arabidopsis thaliana protein match is: WUSCHEL related homeobox 7 (TAIR:AT5G05770.1); Has 538 Blast hits to 538 proteins in 47 species: Archae - 0; Bacteria - 0; Metazoa - 0; Fungi - 0; Plants - 538; Viruses - 0; Other Eukaryotes - 0 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      3527280..3528440
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_111961.4 → NP_187735.2  WUSCHEL related homeobox 5 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_187735.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8H1D2, Q9C775
      UniProtKB/TrEMBL
      A0A178VHH8, A0A384KT15, A0A5S9XB94, C0SVA6
      Conserved Domains (1) summary
      cl00084
      Location:24 → 82
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8H1D2.1

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