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    PAD1 20S proteasome alpha subunit PAD1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 824289, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PAD1
    Official Full Name
    20S proteasome alpha subunit PAD1
    Primary source
    TAIR:AT3G51260
    Locus tag
    AT3G51260
    See related
    Araport:AT3G51260
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    20S proteasome alpha subunit PAD1; 20S proteasome alpha subunit PAD1
    Summary
    20S proteosomal alpha subunits. Interacts with SnRK, SKP1/ASK1 during proteasomal binding of an SCF ubiquitin ligase.
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    Genomic context

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    See PAD1 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    4
    Sequence:
    Chromosome: 3; NC_003074.8 (19030926..19033134)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene flavanone 3-hydroxylase Neighboring gene Senescence/dehydration-associated protein-like protein Neighboring gene tRNA-Asp Neighboring gene protein serine/threonine kinase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. LSD1-, EDS1- and PAD4-dependent conditional correlation among salicylic acid, hydrogen peroxide, water use efficiency and seed yield in Arabidopsis thaliana. Bernacki MJ, et al. Physiol Plant, 2019 Feb. PMID 30461017
    2. SKP1-SnRK protein kinase interactions mediate proteasomal binding of a plant SCF ubiquitin ligase. Farrás R, et al. EMBO J, 2001 Jun 1. PMID 11387208, Free PMC Article
    3. Molecular organization of the 20S proteasome gene family from Arabidopsis thaliana. Fu H, et al. Genetics, 1998 Jun. PMID 9611183, Free PMC Article
    4. The 20S proteasome gene family in Arabidopsis thaliana. Parmentier Y, et al. FEBS Lett, 1997 Oct 27. PMID 9373170
    5. Structure and functional analysis of the 26S proteasome subunits from plants. Fu H, et al. Mol Biol Rep, 1999 Apr. PMID 10363660

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Salicylic acid and hydrogen peroxide are conditionally regulated by LSD1/EDS/PAD4 to govern water use efficiency, biomass accumulation and seed yield.
      Title: LSD1-, EDS1- and PAD4-dependent conditional correlation among salicylic acid, hydrogen peroxide, water use efficiency and seed yield in Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    NM_001035761.1
    NM_114985.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within ubiquitin-dependent protein catabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol HDA PubMed 
    located_in cytosolic ribosome HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in phragmoplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plant-type vacuole HDA PubMed 
    part_of proteasome complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of proteasome core complex TAS
    Traceable Author Statement
    more info
    		 PubMed 
    part_of proteasome core complex, alpha-subunit complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of proteasome core complex, alpha-subunit complex NAS
    Non-traceable Author Statement
    more info
    		  
    located_in spindle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in vacuole HDA PubMed 

    General protein information

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    Preferred Names
    20S proteasome alpha subunit PAD1
    NP_001030838.1
    • 20S proteasome alpha subunit PAD1 (PAD1); FUNCTIONS IN: peptidase activity, endopeptidase activity, threonine-type endopeptidase activity; INVOLVED IN: ubiquitin-dependent protein catabolic process; LOCATED IN: in 8 components; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Proteasome, alpha-subunit, conserved site (InterPro:IPR000426), Proteasome, subunit alpha/beta (InterPro:IPR001353); BEST Arabidopsis thaliana protein match is: proteasome alpha subunit D2 (TAIR:AT5G66140.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_190694.1
    • 20S proteasome alpha subunit PAD1 (PAD1); FUNCTIONS IN: peptidase activity, endopeptidase activity, threonine-type endopeptidase activity; INVOLVED IN: ubiquitin-dependent protein catabolic process; LOCATED IN: in 10 components; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Proteasome, alpha-subunit, conserved site (InterPro:IPR000426), Proteasome, subunit alpha/beta (InterPro:IPR001353); BEST Arabidopsis thaliana protein match is: proteasome alpha subunit D2 (TAIR:AT5G66140.1); Has 5855 Blast hits to 5853 proteins in 462 species: Archae - 847; Bacteria - 1; Metazoa - 1895; Fungi - 1451; Plants - 751; Viruses - 0; Other Eukaryotes - 910 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      19030926..19033134
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_114985.3 → NP_190694.1  20S proteasome alpha subunit PAD1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_190694.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P30186, Q41942, Q8LB36
      UniProtKB/TrEMBL
      A0A178UMI1, A0A178VPE4, A0A5S9XKK7, A0A5S9YHF6
      Conserved Domains (1) summary
      cd03755
      Location:4 → 210
      proteasome_alpha_type_7; The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on top of one another forming ...

    2. NM_001035761.1 → NP_001030838.1  20S proteasome alpha subunit PAD1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001030838.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UMI1, A0A5S9YHF6, Q2V3Q0
      Conserved Domains (2) summary
      TIGR03633
      Location:4 → 211
      arc_protsome_A; proteasome endopeptidase complex, archaeal, alpha subunit
      cd03755
      Location:4 → 210
      proteasome_alpha_type_7; proteasome_alpha_type_7. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P30186.1

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