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    Fes feline sarcoma oncogene [ Mus musculus (house mouse) ]

    Gene ID: 14159, updated on 9-Dec-2024

    Summary

    Official Symbol
    Fesprovided by MGI
    Official Full Name
    feline sarcoma oncogeneprovided by MGI
    Primary source
    MGI:MGI:95514
    See related
    Ensembl:ENSMUSG00000053158 AllianceGenome:MGI:95514
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    FPS; c-fes
    Summary
    Enables microtubule binding activity and protein kinase activity. Acts upstream of or within centrosome cycle and microtubule bundle formation. Located in microtubule cytoskeleton. Is expressed in central nervous system and retina. Human ortholog(s) of this gene implicated in esophagus squamous cell carcinoma; hepatocellular carcinoma; and lung adenocarcinoma. Orthologous to human FES (FES proto-oncogene, tyrosine kinase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in spleen adult (RPKM 20.4), lung adult (RPKM 18.5) and 26 other tissues See more
    Orthologs
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    Genomic context

    See Fes in Genome Data Viewer
    Location:
    7 D2; 7 45.65 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (80027506..80037702, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (80377758..80387954, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene HD domain containing 3 Neighboring gene high mobility group box 2 pseudogene Neighboring gene mannosidase 2, alpha 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:87520664-87520847 Neighboring gene furin, paired basic amino acid cleaving enzyme Neighboring gene predicted gene 44851 Neighboring gene serine hydroxymethyltransferase 2 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (6)  1 citation

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding  
    enables histone H2AXY142 kinase activity  
    enables histone H3Y41 kinase activity  
    enables immunoglobulin receptor binding  
    enables immunoglobulin receptor binding  
    enables microtubule binding PubMed 
    enables non-membrane spanning protein tyrosine kinase activity  
    enables non-membrane spanning protein tyrosine kinase activity  
    enables phosphatidylinositol binding  
    enables phosphatidylinositol binding  
    enables protein binding PubMed 
    enables protein kinase activity PubMed 
    enables protein tyrosine kinase activity  
    enables protein tyrosine kinase activity PubMed 
    enables protein tyrosine kinase activity  
    enables protein tyrosine kinase activity  
    Items 1 - 25 of 32
    Process Evidence Code Pubs
    involved_in cardiac muscle cell proliferation  
    involved_in cell adhesion  
    involved_in cellular response to vitamin D  
    involved_in cellular response to vitamin D  
    acts_upstream_of_or_within centrosome cycle PubMed 
    involved_in chemotaxis  
    involved_in chromatin remodeling  
    acts_upstream_of_or_within microtubule bundle formation PubMed 
    involved_in myoblast proliferation  
    involved_in peptidyl-tyrosine phosphorylation  
    involved_in peptidyl-tyrosine phosphorylation  
    involved_in positive regulation of microtubule polymerization  
    involved_in positive regulation of microtubule polymerization  
    involved_in positive regulation of monocyte differentiation  
    involved_in positive regulation of monocyte differentiation  
    involved_in positive regulation of myeloid cell differentiation  
    involved_in positive regulation of myeloid cell differentiation  
    involved_in positive regulation of neuron projection development  
    involved_in positive regulation of neuron projection development  
    involved_in protein autophosphorylation  
    involved_in regulation of cell adhesion  
    involved_in regulation of cell adhesion  
    involved_in regulation of cell differentiation  
    involved_in regulation of cell differentiation  
    involved_in regulation of cell motility  
    involved_in regulation of cell motility  
    involved_in regulation of cell population proliferation  
    involved_in regulation of cell population proliferation  
    involved_in regulation of cell shape  
    involved_in regulation of cell shape  
    involved_in regulation of mast cell degranulation  
    involved_in regulation of mast cell degranulation  
    Items 1 - 25 of 32
    Component Evidence Code Pubs
    located_in Golgi apparatus  
    located_in cytoplasm  
    located_in cytoplasm  
    located_in cytoplasmic side of plasma membrane  
    located_in cytoplasmic side of plasma membrane  
    colocalizes_with cytoplasmic vesicle  
    colocalizes_with cytoplasmic vesicle  
    located_in cytosol  
    located_in focal adhesion  
    located_in focal adhesion  
    located_in microtubule cytoskeleton PubMed 
    located_in microtubule cytoskeleton  
    located_in microtubule cytoskeleton  
    is_active_in plasma membrane  

    General protein information

    Preferred Names
    tyrosine-protein kinase Fes/Fps
    Names
    proto-oncogene c-Fes
    proto-oncogene tyrosine-protein kinase Fes/Fps
    tyrosine kinase Fps/Fes
    NP_034324.2
    XP_006540667.1
    XP_036008562.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010194.2NP_034324.2  tyrosine-protein kinase Fes/Fps

      See identical proteins and their annotated locations for NP_034324.2

      Status: VALIDATED

      Source sequence(s)
      AC136740, AK143639, BC038130
      Consensus CDS
      CCDS39999.1
      UniProtKB/Swiss-Prot
      P16879, Q3TD20, Q62122, Q8CG02
      UniProtKB/TrEMBL
      A0A0U1RPM2
      Related
      ENSMUSP00000079733.7, ENSMUST00000080932.8
      Conserved Domains (3) summary
      cd07685
      Location:7239
      F-BAR_Fes; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Fes (feline sarcoma) tyrosine kinase
      cd10361
      Location:453537
      SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins
      cl21453
      Location:564814
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      80027506..80037702 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006540604.5XP_006540667.1  tyrosine-protein kinase Fes/Fps isoform X1

      See identical proteins and their annotated locations for XP_006540667.1

      UniProtKB/Swiss-Prot
      P16879, Q3TD20, Q62122, Q8CG02
      UniProtKB/TrEMBL
      A0A0U1RPM2
      Related
      ENSMUSP00000146041.2, ENSMUST00000206728.2
      Conserved Domains (3) summary
      cd07685
      Location:7239
      F-BAR_Fes; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Fes (feline sarcoma) tyrosine kinase
      cd10361
      Location:453537
      SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins
      cl21453
      Location:564814
      PKc_like; Protein Kinases, catalytic domain
    2. XM_036152669.1XP_036008562.1  tyrosine-protein kinase Fes/Fps isoform X2

      Conserved Domains (2) summary
      cd10361
      Location:453537
      SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins
      cl12013
      Location:7239
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    RNA

    1. XR_003946388.1 RNA Sequence

      Related
      ENSMUST00000206744.2
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