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    NSP4 nitrile specifier protein 4 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 820888, updated on 18-Sep-2024

    Summary

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    Official Symbol
    NSP4
    Official Full Name
    nitrile specifier protein 4
    Primary source
    TAIR:AT3G16410
    Locus tag
    AT3G16410
    See related
    Araport:AT3G16410
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    nitrile specifier protein 4; T2O4.17
    Summary
    Encodes a nitrile-specifier protein NSP4. NSP4 is one out of five (At3g16400/NSP1, At2g33070/NSP2, At3g16390/NSP3, At3g16410/NSP4 and At5g48180/NSP5) A. thaliana epithiospecifier protein (ESP) homologues that promote simple nitrile, but not epithionitrile or thiocyanate formation.
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    Genomic context

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    See NSP4 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    5
    Sequence:
    Chromosome: 3; NC_003074.8 (5571903..5574758)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene miscRNA Neighboring gene miscRNA Neighboring gene miscRNA Neighboring gene PYK10-binding protein 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The small RNA-mediated gene silencing machinery is required in Arabidopsis for stimulation of growth, systemic disease resistance, and suppression of the nitrile-specifier gene NSP4 by Trichoderma atroviride. Rebolledo-Prudencio OG, et al. Plant J, 2022 Feb. PMID 34807478
    2. Glucosinolate Content in Dormant and Germinating Arabidopsis thaliana Seeds Is Affected by Non-Functional Alleles of Classical Myrosinase and Nitrile-Specifier Protein Genes. Meier K, et al. Front Plant Sci, 2019. PMID 31850033, Free PMC Article
    3. The genetic basis of constitutive and herbivore-induced ESP-independent nitrile formation in Arabidopsis. Burow M, et al. Plant Physiol, 2009 Jan. PMID 18987211, Free PMC Article
    4. Identification of enzymes for adenosine-to-inosine editing and discovery of cytidine-to-uridine editing in nucleus-encoded transfer RNAs of Arabidopsis. Zhou W, et al. Plant Physiol, 2014 Dec. PMID 25315605, Free PMC Article
    5. Arabidopsis plasmodesmal proteome. Fernandez-Calvino L, et al. PLoS One, 2011 Apr 20. PMID 21533090, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The small RNA-mediated gene silencing machinery is required in Arabidopsis for stimulation of growth, systemic disease resistance, and suppression of the nitrile-specifier gene NSP4 by Trichoderma atroviride.
      Title: The small RNA-mediated gene silencing machinery is required in Arabidopsis for stimulation of growth, systemic disease resistance, and suppression of the nitrile-specifier gene NSP4 by Trichoderma atroviride.
    2. AtNSP4 is one out of five A. thaliana ESP homologues that promote simple nitrile, but not epithionitrile or thiocyanate formation. [AtNSP4]
      Title: The genetic basis of constitutive and herbivore-induced ESP-independent nitrile formation in Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_112512.5

    Gene Ontology Provided by TAIR

    Process Evidence Code Pubs
    acts_upstream_of_or_within glucosinolate catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within nitrile biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in seed germination IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol HDA PubMed 
    located_in plasmodesma HDA PubMed 

    General protein information

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    Preferred Names
    nitrile specifier protein 4
    NP_188262.1
    • nitrile specifier protein 4 (NSP4); CONTAINS InterPro DOMAIN/s: Galactose oxidase/kelch, beta-propeller (InterPro:IPR011043), Kelch repeat type 1 (InterPro:IPR006652), Mannose-binding lectin (InterPro:IPR001229), Kelch-type beta propeller (InterPro:IPR015915); BEST Arabidopsis thaliana protein match is: nitrile specifier protein 1 (TAIR:AT3G16400.2); Has 13279 Blast hits to 7146 proteins in 431 species: Archae - 15; Bacteria - 460; Metazoa - 7495; Fungi - 707; Plants - 3102; Viruses - 40; Other Eukaryotes - 1460 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      5571903..5574758
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_112512.5 → NP_188262.1  nitrile specifier protein 4 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_188262.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O04316
      Conserved Domains (6) summary
      PLN02193
      Location:150 → 619
      PLN02193; nitrile-specifier protein
      sd00038
      Location:370 → 414
      Kelch; KELCH repeat [structural motif]
      pfam01344
      Location:467 → 511
      Kelch_1; Kelch motif
      pfam01419
      Location:162 → 291
      Jacalin; Jacalin-like lectin domain
      pfam13415
      Location:377 → 426
      Kelch_3; Galactose oxidase, central domain
      pfam13964
      Location:315 → 355
      Kelch_6; Kelch motif
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O04316.1

    Gene LinkOut

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