RVE8 Homeodomain-like superfamily protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: RVE8
Official Full Name: Homeodomain-like superfamily protein
Primary source: TAIR:AT3G09600
Locus tag: AT3G09600
See related: Araport:AT3G09600
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: AT3G09610; LCL5; LHY-CCA1-LIKE5; REVEILLE 8
Summary: Encodes a MYB-like transcription factor similar to CIRCADIAN CLOCK-ASSOCIATED1 (CCA1) and ELONGATED HYPOCOTYL (LHY). Involved in the regulation of circadian clock by modulating the pattern of histone 3 (H3) acetylation.
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Genomic context

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See RVE8 in Genome Data Viewer

Location:: chromosome: 3

Exon count:: 8

Sequence:: Chromosome: 3; NC_003074.8 (2946239..2949017)

Chromosome 3 - NC_003074.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

REVEILLE clock genes rve3 4 5 6 8 mutants are much larger than wild-type plants, with both increased leaf area and biomass.
Title: The REVEILLE Clock Genes Inhibit Growth of Juvenile and Adult Plants by Control of Cell Size.
This study defines a switch in the regulatory activity of RVE8-LNK interaction, from a synergic coactivating role of evening-expressed clock genes to a repressive antagonistic function modulating anthocyanin biosynthesis around midday.
Title: Time-dependent sequestration of RVE8 by LNK proteins shapes the diurnal oscillation of anthocyanin biosynthesis.
RVE8 affects Global Circadian-regulated transcription. Long-period mutant in Arabidopsis, rve8-1, has a global alteration in phase of all clock-controlled genes. [RVE8]
Title: Circadian phase has profound effects on differential expression analysis.
RVE8/LCL5 binds to the promoter of key clock component TOC1 (Timing of CAB expression 1) and regulates its circadian expression.
Title: Histone acetylation and the circadian clock: a role for the MYB transcription factor RVE8/LCL5.
RVE8 is a new component of the plant circadian oscillator that takes part in a novel transcriptional feedback loop. [REVEILLE 8] [RVE8].
Title: REVEILLE8 and PSEUDO-REPONSE REGULATOR5 form a negative feedback loop within the Arabidopsis circadian clock.
RVE8/LCL5 expression shows a rhythmic oscillation that is controlled by the circadian clock. Alteration of RVE8/LCL5 expression affects the photoperiodic regulation of flowering time.
Title: Functional implication of the MYB transcription factor RVE8/LCL5 in the circadian control of histone acetylation.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_001035585.4

Supported by ESTs:

NM_001337830.1

Supported by ESTs:

NM_001337831.1

Supported by ESTs:

NM_001337832.1

Supported by ESTs:

NM_001337833.1

Supported by ESTs:

NM_001337834.1

Supported by ESTs:

NM_111794.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within circadian regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within photoperiodism, flowering	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of circadian rhythm	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within regulation of circadian rhythm	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: Homeodomain-like superfamily protein

NP_001030662.1

Homeodomain-like superfamily protein; FUNCTIONS IN: DNA binding, sequence-specific DNA binding transcription factor activity; INVOLVED IN: in 9 processes; LOCATED IN: chloroplast; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: SANT, DNA-binding (InterPro:IPR001005), Homeodomain-like (InterPro:IPR009057), Myb, DNA-binding (InterPro:IPR014778), HTH transcriptional regulator, Myb-type, DNA-binding (InterPro:IPR017930), Myb-like DNA-binding domain, SHAQKYF class (InterPro:IPR006447); BEST Arabidopsis thaliana protein match is: LHY/CCA1-like 1 (TAIR:AT5G02840.2); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

NP_187571.2

Homeodomain-like superfamily protein; FUNCTIONS IN: DNA binding, sequence-specific DNA binding transcription factor activity; INVOLVED IN: in 9 processes; LOCATED IN: chloroplast; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: SANT, DNA-binding (InterPro:IPR001005), Homeodomain-like (InterPro:IPR009057), Myb, DNA-binding (InterPro:IPR014778), HTH transcriptional regulator, Myb-type, DNA-binding (InterPro:IPR017930), Myb-like DNA-binding domain, SHAQKYF class (InterPro:IPR006447); BEST Arabidopsis thaliana protein match is: LHY/CCA1-like 1 (TAIR:AT5G02840.3); Has 1480 Blast hits to 1470 proteins in 124 species: Archae - 0; Bacteria - 0; Metazoa - 145; Fungi - 6; Plants - 1120; Viruses - 0; Other Eukaryotes - 209 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003074.8 Reference assembly

Range

2946239..2949017

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001337828.1 → NP_001327347.1 Homeodomain-like superfamily protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A178VMH4, A0A1I9LS11

Conserved Domains (1) summary

cl21498
Location:10 → 35

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
NM_001337829.1 → NP_001327351.1 Homeodomain-like superfamily protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1I9LS15, A0A7G2EH30

Conserved Domains (2) summary

TIGR01557
Location:41 → 91

myb_SHAQKYF; myb-like DNA-binding domain, SHAQKYF class

COG5114
Location:44 → 150

COG5114; Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics]
NM_001035585.4 → NP_001030662.1 Homeodomain-like superfamily protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001030662.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A7G2EH30

Conserved Domains (2) summary

TIGR01557
Location:41 → 91

myb_SHAQKYF; myb-like DNA-binding domain, SHAQKYF class

COG5114
Location:44 → 150

COG5114; Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics]
NM_111794.4 → NP_187571.2 Homeodomain-like superfamily protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_187571.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q6QAC9, Q8RWU3, Q9SF43

UniProtKB/TrEMBL

A0A5S9XAT1, A0A654F5H0, A0A7G2EH30

Conserved Domains (2) summary

TIGR01557
Location:41 → 91

myb_SHAQKYF; myb-like DNA-binding domain, SHAQKYF class

COG5114
Location:44 → 150

COG5114; Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics]
NM_001337830.1 → NP_001327350.1 Homeodomain-like superfamily protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A178VMH4, A0A1I9LS14

Conserved Domains (1) summary

cl21498
Location:10 → 35

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
NM_001337831.1 → NP_001327349.1 Homeodomain-like superfamily protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A7G2EH30

Conserved Domains (2) summary

TIGR01557
Location:41 → 91

myb_SHAQKYF; myb-like DNA-binding domain, SHAQKYF class

COG5114
Location:44 → 150

COG5114; Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics]
NM_001337832.1 → NP_001327348.1 Homeodomain-like superfamily protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q6QAC9, Q8RWU3, Q9SF43

UniProtKB/TrEMBL

A0A5S9XAT1, A0A654F5H0, A0A7G2EH30

Conserved Domains (2) summary

TIGR01557
Location:41 → 91

myb_SHAQKYF; myb-like DNA-binding domain, SHAQKYF class

COG5114
Location:44 → 150

COG5114; Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics]
NM_001337833.1 → NP_001327346.1 Homeodomain-like superfamily protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A178VMH4, A0A1I9LS11

Conserved Domains (1) summary

cl21498
Location:10 → 35

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
NM_001337834.1 → NP_001327345.1 Homeodomain-like superfamily protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A178VMH4, A0A1I9LS14

Conserved Domains (1) summary

cl21498
Location:10 → 35

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...