Dmrt2 doublesex and mab-3 related transcription factor 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dmrt2provided by MGI
Official Full Name: doublesex and mab-3 related transcription factor 2provided by MGI
Primary source: MGI:MGI:1330307
See related: Ensembl:ENSMUSG00000048138 AllianceGenome:MGI:1330307
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Terra
Summary: Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within embryonic skeletal system development; positive regulation of myotome development; and regulation of somitogenesis. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; branchial arch; embryo mesenchyme; genitourinary system; and long bone. Orthologous to human DMRT2 (doublesex and mab-3 related transcription factor 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in subcutaneous fat pad adult (RPKM 19.6), mammary gland adult (RPKM 12.3) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 C1; 19 20.53 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (25649758..25656355)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (25672394..25679013)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TERRA expression is regulated by the telomere-binding proteins POT-1 and POT-2 in Caenorhabditis elegans.
Title: TERRA expression is regulated by the telomere-binding proteins POT-1 and POT-2 in Caenorhabditis elegans.
Dmrt2 promotes transition of endochondral bone formation by linking Sox9 and Runx2.
Title: Dmrt2 promotes transition of endochondral bone formation by linking Sox9 and Runx2.
Dynamics of telomeric repeat-containing RNA expression in early embryonic cleavage stages with regards to maternal age.
Title: Dynamics of telomeric repeat-containing RNA expression in early embryonic cleavage stages with regards to maternal age.
TERRA expression and interactome during Primordial germ cells development are regulated in a dynamic fashion that is dependent on gestational age and sex.
Title: Characterization of telomeric repeat-containing RNA (TERRA) localization and protein interactions in primordial germ cells of the mouse†.
We show here that the unstructured hinge domain, necessary for the targeting of HP1alpha to constitutive heterochromatin, recognizes parallel G-quadruplex (G4) assemblies formed by the TElomeric Repeat-containing RNA (TERRA) transcribed from the telomere.
Title: Heterochromatin protein 1α interacts with parallel RNA and DNA G-quadruplexes.
Here, we show that TNF-alpha, which is induced by various psychological stresses, induces the p38-dependent phosphorylation of ATF7, a stress-responsive chromatin regulator, in mouse testicular germ cells. This caused a release of ATF7 from the TERRA gene promoter in the subtelomeric region, which disrupted heterochromatin and induced TERRA.
Title: Telomere shortening by transgenerational transmission of TNF-α-induced TERRA via ATF7.
Findings indicate that CCCTC-binding factor (CTCF)-driven doublesex and mab-3 related transcription factor 2 protein (TERRA) transcription acts in cis to facilitate telomere repeat replication and chromosome stability.
Title: CTCF driven TERRA transcription facilitates completion of telomere DNA replication.
the role of dmrt2 gene is not conserved during zebrafish and mouse embryonic development
Title: Left-right function of dmrt2 genes is not conserved between zebrafish and mouse.
These results reveal a novel genetic network, comprising a Pax3/Dmrt2/Myf5 regulatory cascade that operates in stem cells of the epaxial dermomyotome to initiate skeletal muscle formation.
Title: A Pax3/Dmrt2/Myf5 regulatory cascade functions at the onset of myogenesis.
Dmrt2 is associated with embryonic myogensis.
Title: Dmrt2 and Pax3 double-knockout mice show severe defects in embryonic myogenesis.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dmrt2 (e-PCR), detects polymorphism
- UniSTS:525898

MGI:3841783 (e-PCR)
- UniSTS:525899

Dmrt2 (e-PCR), detects polymorphism
- UniSTS:257210

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IC Inferred by Curator more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IMP Inferred from Mutant Phenotype more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within embryonic skeletal system development	IMP Inferred from Mutant Phenotype more info	PubMed
NOT acts_upstream_of_or_within left/right pattern formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of myotome development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of myotome development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of somitogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of somitogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in sex differentiation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: doublesex- and mab-3-related transcription factor 2

Names: doublesex-like 2 protein; terra homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_145831.3 → NP_665830.1 doublesex- and mab-3-related transcription factor 2

See identical proteins and their annotated locations for NP_665830.1

Status: VALIDATED

Source sequence(s)

AC124540, AC132140

Consensus CDS

CCDS29719.1

UniProtKB/Swiss-Prot

Q3USI4, Q3USI7, Q8BG36, Q8K185, Q9JJU0, Q9JJU3, Q9WVM0

Related

ENSMUSP00000059654.6, ENSMUST00000053068.7

Conserved Domains (1) summary

pfam00751
Location:119 → 165

DM; DM DNA binding domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000085.7 Reference GRCm39 C57BL/6J

Range

25649758..25656355

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006526983.4 → XP_006527046.1 doublesex- and mab-3-related transcription factor 2 isoform X2

Conserved Domains (1) summary

pfam00751
Location:119 → 165

DM; DM DNA binding domain
XM_036161560.1 → XP_036017453.1 doublesex- and mab-3-related transcription factor 2 isoform X1