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    ZF2 zinc-finger protein 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 821495, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ZF2
    Official Full Name
    zinc-finger protein 2
    Primary source
    TAIR:AT3G19580
    Locus tag
    AT3G19580
    See related
    Araport:AT3G19580
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AZF2; MMB12.27; zinc-finger protein 2
    Summary
    Encodes zinc finger protein. mRNA levels are upregulated in response to ABA, high salt, and mild dessication. The protein is localized to the nucleus and acts as a transcriptional repressor.
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    Genomic context

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    See ZF2 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    1
    Sequence:
    Chromosome: 3; NC_003074.8 (6802903..6804296, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene F-box/associated interaction domain protein Neighboring gene SNOWY COTYLEDON protein (DUF566) Neighboring gene Transducin/WD40 repeat-like superfamily protein Neighboring gene ncRNA Neighboring gene Haloacid dehalogenase-like hydrolase (HAD) superfamily protein Neighboring gene RNA polymerase II carboxy-terminal domain phosphatase-like protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis zinc-finger protein 2 is a negative regulator of ABA signaling during seed germination. Drechsel G, et al. J Plant Physiol, 2010 Nov 1. PMID 20619483
    2. Arabidopsis Cys2/His2 zinc-finger proteins AZF1 and AZF2 negatively regulate abscisic acid-repressive and auxin-inducible genes under abiotic stress conditions. Kodaira KS, et al. Plant Physiol, 2011 Oct. PMID 21852415, Free PMC Article
    3. Mitochondrial AtTrxo1 is transcriptionally regulated by AtbZIP9 and AtAZF2 and affects seed germination under saline conditions. Ortiz-Espín A, et al. J Exp Bot, 2017 Feb 1. PMID 28184497, Free PMC Article
    4. Gene network analysis and functional studies of senescence-associated genes reveal novel regulators of Arabidopsis leaf senescence. Li Z, et al. J Integr Plant Biol, 2012 Aug. PMID 22709441
    5. Expression of a subset of the Arabidopsis Cys(2)/His(2)-type zinc-finger protein gene family under water stress. Sakamoto H, et al. Gene, 2000 May 2. PMID 10806347

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Transcript regulation of AtbZIP9 and AtAFZ2 during germination was compatible with the proposed role in transcriptional regulation of AtTrxo1. Transient over-expression of AtbZIP9 and AtAZF2 in Nicotiana benthamiana leaves demonstrated an activation effect of AtbZIP9 and a repressor effect of AtAZF2 on AtTrxo1 promoter-driven reporter expression.
      Title: Mitochondrial AtTrxo1 is transcriptionally regulated by AtbZIP9 and AtAZF2 and affects seed germination under saline conditions.
    2. positive regulator of leaf senescence
      Title: Gene network analysis and functional studies of senescence-associated genes reveal novel regulators of Arabidopsis leaf senescence.
    3. AZF1 and AZF2 function as transcriptional repressors involved in the inhibition of plant growth under abiotic stress conditions.
      Title: Arabidopsis Cys2/His2 zinc-finger proteins AZF1 and AZF2 negatively regulate abscisic acid-repressive and auxin-inducible genes under abiotic stress conditions.
    4. Results indicate that AZF2 is a negative regulator of ABA signaling in seeds.
      Title: Arabidopsis zinc-finger protein 2 is a negative regulator of ABA signaling during seed germination.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001125191.1
    NM_112848.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transcription cis-regulatory region binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within embryo development ending in seed dormancy IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within hyperosmotic salinity response IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to abscisic acid IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to abscisic acid IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to water deprivation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    zinc-finger protein 2
    NP_001118663.1
    • zinc-finger protein 2 (ZF2); CONTAINS InterPro DOMAIN/s: Zinc finger, C2H2-like (InterPro:IPR015880), Zinc finger, C2H2-type (InterPro:IPR007087); BEST Arabidopsis thaliana protein match is: salt tolerance zinc finger (TAIR:AT1G27730.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
    NP_188592.1
    • zinc-finger protein 2 (ZF2); CONTAINS InterPro DOMAIN/s: Zinc finger, C2H2-like (InterPro:IPR015880), Zinc finger, C2H2-type (InterPro:IPR007087); BEST Arabidopsis thaliana protein match is: salt tolerance zinc finger (TAIR:AT1G27730.1); Has 3838 Blast hits to 3100 proteins in 116 species: Archae - 0; Bacteria - 0; Metazoa - 2857; Fungi - 6; Plants - 884; Viruses - 0; Other Eukaryotes - 91 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      6802903..6804296 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_112848.2 → NP_188592.1  zinc-finger protein 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_188592.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9SSW2
      UniProtKB/TrEMBL
      A0A178VJ97, A0A5S9XE45
      Conserved Domains (2) summary
      sd00017
      Location:108 → 128
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13912
      Location:164 → 189
      zf-C2H2_6; C2H2-type zinc finger

    2. NM_001125191.1 → NP_001118663.1  zinc-finger protein 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001118663.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9SSW2
      UniProtKB/TrEMBL
      A0A178VJ97, A0A5S9XE45
      Conserved Domains (2) summary
      sd00017
      Location:108 → 128
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13912
      Location:164 → 189
      zf-C2H2_6; C2H2-type zinc finger
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SSW2.1

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