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    CDKB1;1 cyclin-dependent kinase B1;1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 824585, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CDKB1;1
    Official Full Name
    cyclin-dependent kinase B1;1
    Primary source
    TAIR:AT3G54180
    Locus tag
    AT3G54180
    See related
    Araport:AT3G54180
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    CDC2-LIKE GENE; CDC2B; cyclin-dependent kinase B1;1; CYCLIN-DEPENDENT KINASE B1;1; P34(CDC2)-LIKE PROTEIN
    Summary
    Arabidopsis homolog of yeast cdc2, a protein kinase (cyclin-dependent kinase) that plays a central role in control of the mitotic cell cycle.
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    Genomic context

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    See CDKB1;1 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    4
    Sequence:
    Chromosome: 3; NC_003074.8 (20059671..20061488)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene RNI-like superfamily protein Neighboring gene FKBP12 interacting protein 37 Neighboring gene Transducin/WD40 repeat-like superfamily protein Neighboring gene Late embryogenesis abundant (LEA) hydroxyproline-rich glycoprotein family Neighboring gene miscRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. What if higher plants lack a CDC25 phosphatase? Boudolf V, et al. Trends Plant Sci, 2006 Oct. PMID 16949857
    2. Exon-intron organization of the Arabidopsis thaliana protein kinase genes CDC2a and CDC2b. Imajuku Y, et al. FEBS Lett, 1992 Jun 8. PMID 1618302
    3. An Arabidopsis cell cycle -dependent kinase-related gene, CDC2b, plays a role in regulating seedling growth in darkness. Yoshizumi T, et al. Plant Cell, 1999 Oct. PMID 10521519, Free PMC Article
    4. B1-type cyclin-dependent kinases are essential for the formation of stomatal complexes in Arabidopsis thaliana. Boudolf V, et al. Plant Cell, 2004 Apr. PMID 15031414, Free PMC Article
    5. A sustained CYCLINB1;1 and STM expression in the neoplastic tissues induced by Rhodococcus fascians on Arabidopsis underlies the persistence of the leafy gall structure. Dolzblasz A, et al. Plant Signal Behav, 2020 Dec 1. PMID 32897774, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A sustained CYCLINB1;1 and STM expression in the neoplastic tissues induced by Rhodococcus fascians on Arabidopsis underlies the persistence of the leafy gall structure.
      Title: A sustained CYCLINB1;1 and STM expression in the neoplastic tissues induced by Rhodococcus fascians on Arabidopsis underlies the persistence of the leafy gall structure.
    2. The authors identify the plant-specific B1-type CDKs (CDKB1s) and the class of B1-type cyclins (CYCB1s) as major regulators of homology-dependent repair in plants.
      Title: The plant-specific CDKB1-CYCB1 complex mediates homologous recombination repair in Arabidopsis.
    3. Plant separase, in addition to cleaving cohesin, regulates cyclin B1;1, with profound ramifications for morphogenesis.
      Title: A conditional mutation in Arabidopsis thaliana separase induces chromosome non-disjunction, aberrant morphogenesis and cyclin B1;1 stability.
    4. CCS52A1 participates in endocycle onset by down-regulating CDKB1;1 activity through the destruction of CYCA2;3.
      Title: CDKB1;1 forms a functional complex with CYCA2;3 to suppress endocycle onset.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_115278.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables RNA polymerase II CTD heptapeptide repeat kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cyclin-dependent protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA endoreduplication TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within cotyledon development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in guard mother cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of DNA endoreduplication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell cycle G1/S phase transition IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of stomatal complex patterning IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within stomatal complex formation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in stomatal complex formation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within stomatal complex formation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within unidimensional cell growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    cyclin-dependent kinase B1;1
    NP_190986.1
    • cyclin-dependent kinase B1;1 (CDKB1;1); CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Protein kinase, catalytic domain (InterPro:IPR000719), Serine/threonine-protein kinase domain (InterPro:IPR002290), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: cyclin-dependent kinase B1;2 (TAIR:AT2G38620.2); Has 100146 Blast hits to 99045 proteins in 2954 species: Archae - 92; Bacteria - 10121; Metazoa - 38796; Fungi - 11639; Plants - 20773; Viruses - 421; Other Eukaryotes - 18304 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      20059671..20061488
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_115278.3 → NP_190986.1  cyclin-dependent kinase B1;1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_190986.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P25859, Q147L4
      UniProtKB/TrEMBL
      A0A178VIJ9, A0A5S9XMD5
      Conserved Domains (1) summary
      cl21453
      Location:2 → 302
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P25859.2

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