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    Dhrs2 dehydrogenase/reductase member 2 [ Mus musculus (house mouse) ]

    Gene ID: 71412, updated on 9-Dec-2024

    Summary

    Official Symbol
    Dhrs2provided by MGI
    Official Full Name
    dehydrogenase/reductase member 2provided by MGI
    Primary source
    MGI:MGI:1918662
    See related
    Ensembl:ENSMUSG00000022209 AllianceGenome:MGI:1918662
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hep27; 5430405K24Rik
    Summary
    Predicted to enable carbonyl reductase (NADPH) activity. Predicted to be involved in several processes, including cellular response to oxidative stress; electron transport chain; and negative regulation of apoptotic process. Predicted to be located in mitochondrion; nuclear envelope; and nucleoplasm. Is expressed in lower lip and upper lip. Orthologous to human DHRS2 (dehydrogenase/reductase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
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    Genomic context

    See Dhrs2 in Genome Data Viewer
    Location:
    14 C3; 14 28.12 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (55459464..55478897)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (55222007..55241440)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr14:55780296-55780597 Neighboring gene predicted gene, 53860 Neighboring gene predicted gene, 46455 Neighboring gene predicted gene, 23596 Neighboring gene STARR-seq mESC enhancer starr_36764 Neighboring gene STARR-seq mESC enhancer starr_36766 Neighboring gene STARR-seq mESC enhancer starr_36767 Neighboring gene R3H domain containing 2 pseudogene Neighboring gene myosin light polypeptide 6 alkali smooth muscle and non-muscle protein, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1) 

    General gene information

    Clone Names

    • MGC143467

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    located_in cytoplasm  
    located_in mitochondrion  
    located_in nuclear envelope  
    located_in nucleoplasm  
    located_in nucleus  

    General protein information

    Preferred Names
    dehydrogenase/reductase SDR family member 2, mitochondrial
    Names
    SDR family member

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027790.2 → NP_082066.2  dehydrogenase/reductase SDR family member 2, mitochondrial

      See identical proteins and their annotated locations for NP_082066.2

      Status: VALIDATED

      Source sequence(s)
      AC123533, AK017274, AV291604, BC117731
      Consensus CDS
      CCDS27110.1
      UniProtKB/TrEMBL
      Q149L0, Q9D3M7
      Related
      ENSMUSP00000022820.6, ENSMUST00000022820.12
      Conserved Domains (1) summary
      cl21454
      Location:35 → 277
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      55459464..55478897
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011245200.4 → XP_011243502.1  dehydrogenase/reductase SDR family member 2, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_011243502.1

      UniProtKB/TrEMBL
      Q149L0, Q9D3M7
      Conserved Domains (1) summary
      cl21454
      Location:35 → 277
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    2. XM_006519570.3 → XP_006519633.1  dehydrogenase/reductase SDR family member 2, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_006519633.1

      UniProtKB/TrEMBL
      Q149L0, Q9D3M7
      Related
      ENSMUSP00000129115.2, ENSMUST00000165432.2
      Conserved Domains (1) summary
      cl21454
      Location:35 → 277
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
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