St6galnac1 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: St6galnac1provided by MGI
Official Full Name: ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1provided by MGI
Primary source: MGI:MGI:1341826
See related: Ensembl:ENSMUSG00000009588 AllianceGenome:MGI:1341826
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Siat7a
Summary: Enables alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity. Involved in host-mediated regulation of intestinal microbiota composition. Acts upstream of or within oligosaccharide biosynthetic process. Predicted to be located in membrane. Predicted to be active in Golgi membrane. Is expressed in colon; mammary gland; and salivary gland. Used to study inflammatory bowel disease. Orthologous to human ST6GALNAC1 (ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in colon adult (RPKM 3.7), thymus adult (RPKM 2.2) and 8 other tissues See more
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Genomic context

Location:: 11 E2; 11 81.49 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (116655851..116666333, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (116765025..116775507, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results suggest a role of ST6GalNAc I in promoting the growth and invasion of hepatocarcinoma cells through regulating PI3K/AKT/NF-kappa B signaling, and ST6GalNAc I might be a marker for the prognosis and therapy of hepatocarcinoma.
Title: Silencing of ST6GalNAc I suppresses the proliferation, migration and invasion of hepatocarcinoma cells through PI3K/AKT/NF-κB pathway.
It was confirmed that MUC1 carries sialyl Tn also in human advanced gastric cancer tissues
Title: Enhancement of metastatic ability by ectopic expression of ST6GalNAcI on a gastric cancer cell line in a mouse model.
ST6GalNAc I has a role in O-glycosylation of the integrin beta1 chain and integrin beta 1-mediated signalling
Title: Expression of sialyl-Tn epitopes on beta1 integrin alters epithelial cell phenotype, proliferation and haptotaxis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation

General gene information

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Markers

Siat7a (e-PCR), detects polymorphism
- UniSTS:261917

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within ganglioside biosynthetic process	TAS Traceable Author Statement more info	PubMed
involved_in host-mediated regulation of intestinal microbiota composition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in modulation by host of symbiont process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oligosaccharide biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within oligosaccharide biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in protein glycosylation	IEA Inferred from Electronic Annotation more info
involved_in protein glycosylation	ISO Inferred from Sequence Orthology more info
involved_in protein glycosylation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in Golgi membrane	ISO Inferred from Sequence Orthology more info
is_active_in Golgi membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1

Names: SIAT7-A; ST6GalNAc I; ST6GalNAcI; sialyltransferase 7 ((alpha-N-acetylneuraminyl 2,3-beta-galactosyl-1,3)-N-acetyl galactosaminde alpha-2,6-sialyltransferase) A; sialyltransferase 7A

NP_035501.2

EC 2.4.3.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011371.2 → NP_035501.2 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1

See identical proteins and their annotated locations for NP_035501.2

Status: VALIDATED

Source sequence(s)

AL645542, BE847090, Y11274

Consensus CDS

CCDS36380.1

UniProtKB/Swiss-Prot

A2AA23, Q9JJP5, Q9QZ39

UniProtKB/TrEMBL

B7ZNQ3

Related

ENSMUSP00000009732.8, ENSMUST00000009732.8

Conserved Domains (2) summary

pfam00777
Location:231 → 517

Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

pfam05466
Location:45 → 169

BASP1; Brain acid soluble protein 1 (BASP1 protein)