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    LYK4 protein kinase family protein / peptidoglycan-binding LysM domain-containing protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 816909, updated on 18-Sep-2024

    Summary

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    Official Symbol
    LYK4
    Official Full Name
    protein kinase family protein / peptidoglycan-binding LysM domain-containing protein
    Primary source
    TAIR:AT2G23770
    Locus tag
    AT2G23770
    See related
    Araport:AT2G23770
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtLYK4; F27L4.5; F27L4_5; LysM-containing receptor-like kinase 4
    Summary
    Encodes a LysM-containing receptor-like kinase LYK4. Shares overlapping function with LYK5 in mediating chitin-triggered immune responses.
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    Genomic context

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    See LYK4 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    1
    Sequence:
    Chromosome: 2; NC_003071.7 (10119973..10122479, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene histone-lysine N-methyltransferase SUVR5 Neighboring gene transmembrane family 220 helix protein Neighboring gene BEL1-like homeodomain 4 Neighboring gene RING/U-box superfamily protein Neighboring gene calcium uniporter (DUF607)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. LYK4 is a component of a tripartite chitin receptor complex in Arabidopsis thaliana. Xue DX, et al. J Exp Bot, 2019 Oct 15. PMID 31270545
    2. The kinase LYK5 is a major chitin receptor in Arabidopsis and forms a chitin-induced complex with related kinase CERK1. Cao Y, et al. Elife, 2014 Oct 23. PMID 25340959, Free PMC Article
    3. LYK4, a lysin motif receptor-like kinase, is important for chitin signaling and plant innate immunity in Arabidopsis. Wan J, et al. Plant Physiol, 2012 Sep. PMID 22744984, Free PMC Article
    4. Novel Aquaporin Regulatory Mechanisms Revealed by Interactomics. Bellati J, et al. Mol Cell Proteomics, 2016 Nov. PMID 27609422, Free PMC Article
    5. Border control--a membrane-linked interactome of Arabidopsis. Jones AM, et al. Science, 2014 May 16. PMID 24833385

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LYK4 functions as a LYK5-associated co-receptor or scaffold protein that enhances chitin-induced signaling in Arabidopsis.
      Title: LYK4 is a component of a tripartite chitin receptor complex in Arabidopsis thaliana.
    2. LYK4 may play a role in the chitin recognition receptor complex to assist chitin signal transduction and plant innate immunity.
      Title: LYK4, a lysin motif receptor-like kinase, is important for chitin signaling and plant innate immunity in Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_127940.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables chitin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to chitin IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in cellular response to molecule of bacterial origin IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within innate immune response IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein kinase family protein / peptidoglycan-binding LysM domain-containing protein
    NP_179957.1
    • protein kinase family protein / peptidoglycan-binding LysM domain-containing protein; FUNCTIONS IN: kinase activity; INVOLVED IN: protein amino acid phosphorylation, cell wall macromolecule catabolic process; LOCATED IN: endomembrane system; EXPRESSED IN: stem, leaf whorl, root, leaf; EXPRESSED DURING: LP.06 six leaves visible, LP.12 twelve leaves visible; CONTAINS InterPro DOMAIN/s: Peptidoglycan-binding lysin domain (InterPro:IPR018392), Immunoglobulin-like (InterPro:IPR007110), Protein kinase, catalytic domain (InterPro:IPR000719), Peptidoglycan-binding Lysin subgroup (InterPro:IPR002482), Serine-threonine/tyrosine-protein kinase (InterPro:IPR001245), Protein kinase-like domain (InterPro:IPR011009); BEST Arabidopsis thaliana protein match is: Protein kinase superfamily protein (TAIR:AT2G33580.1); Has 93408 Blast hits to 92552 proteins in 3130 species: Archae - 75; Bacteria - 9623; Metazoa - 34895; Fungi - 6839; Plants - 28747; Viruses - 328; Other Eukaryotes - 12901 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      10119973..10122479 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_127940.2 → NP_179957.1  protein kinase family protein / peptidoglycan-binding LysM domain-containing protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_179957.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O64825
      UniProtKB/TrEMBL
      A0A5S9X0U1
      Conserved Domains (2) summary
      pfam01476
      Location:121 → 166
      LysM; LysM domain
      cl21453
      Location:378 → 597
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O64825.1

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