Srsf6 serine and arginine-rich splicing factor 6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Srsf6provided by MGI
Official Full Name: serine and arginine-rich splicing factor 6provided by MGI
Primary source: MGI:MGI:1915246
See related: Ensembl:ENSMUSG00000016921 AllianceGenome:MGI:1915246
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Sfrs6; 1210001E11Rik
Summary: The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. [provided by RefSeq, Sep 2010]
Expression: Ubiquitous expression in adrenal adult (RPKM 167.2), CNS E11.5 (RPKM 118.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 H2; 2 83.87 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (162773428..162779041)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (162931508..162937121)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SRSF6 balances mitochondrial-driven innate immune outcomes through alternative splicing of BAX.
Title: SRSF6 balances mitochondrial-driven innate immune outcomes through alternative splicing of BAX.
DRAK2 aggravates nonalcoholic fatty liver disease progression through SRSF6-associated RNA alternative splicing.
Title: DRAK2 aggravates nonalcoholic fatty liver disease progression through SRSF6-associated RNA alternative splicing.
Nova1 isoforms exhibited differential effects on repressing the development of BAs. Moreover, overexpression of Nova1 proteins reduced the serine/arginine splicing factor 6 (SRSF6) level by enhancing the generation of intron 2-included (SRSF6(+intron 2)) transcripts
Title: RBM4-Nova1-SRSF6 splicing cascade modulates the development of brown adipocytes.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Sfrs6 (e-PCR), detects polymorphism
- UniSTS:479268

AI314910 (e-PCR)
- UniSTS:159067

NoName (e-PCR)
- UniSTS:234593

D19287 (e-PCR)
- UniSTS:124802

AW146126 (e-PCR)
- UniSTS:181230

AA874922 (e-PCR)
- UniSTS:245488

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	ISO Inferred from Sequence Orthology more info
enables RNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables pre-mRNA binding	ISO Inferred from Sequence Orthology more info
enables pre-mRNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in alternative mRNA splicing, via spliceosome	ISO Inferred from Sequence Orthology more info
involved_in alternative mRNA splicing, via spliceosome	ISS Inferred from Sequence or Structural Similarity more info
involved_in mRNA splice site recognition	ISO Inferred from Sequence Orthology more info
involved_in mRNA splice site recognition	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of keratinocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of keratinocyte differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of mRNA splicing, via spliceosome	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of mRNA splicing, via spliceosome	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of type B pancreatic cell apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of type B pancreatic cell apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of epithelial cell proliferation involved in lung morphogenesis	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within regulation of alternative mRNA splicing, via spliceosome	ISO Inferred from Sequence Orthology more info	PubMed
involved_in regulation of alternative mRNA splicing, via spliceosome	ISO Inferred from Sequence Orthology more info
involved_in regulation of alternative mRNA splicing, via spliceosome	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of keratinocyte proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of keratinocyte proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of wound healing	ISO Inferred from Sequence Orthology more info
involved_in regulation of wound healing	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to insulin	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: serine/arginine-rich splicing factor 6

Names: pre-mRNA-splicing factor SRP55; splicing factor, arginine/serine-rich 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_026499.4 → NP_080775.3 serine/arginine-rich splicing factor 6

See identical proteins and their annotated locations for NP_080775.3

Status: REVIEWED

Source sequence(s)

AK133872, AL590418, AL606473, BY783855

Consensus CDS

CCDS17002.1

UniProtKB/Swiss-Prot

Q3TWW8, Q3UJV5, Q921K3, Q9DBP1

Related

ENSMUSP00000119065.2, ENSMUST00000130411.7

Conserved Domains (2) summary

cd12766
Location:110 → 182

RRM2_SRSF6; RNA recognition motif 2 (RRM2) found found in vertebrate serine/arginine-rich splicing factor 6 (SRSF6)

cl17169
Location:1 → 72

RRM_SF; RNA recognition motif (RRM) superfamily