U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    ORC2 origin recognition complex second largest subunit 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 818332, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    ORC2
    Official Full Name
    origin recognition complex second largest subunit 2
    Primary source
    TAIR:AT2G37560
    Locus tag
    AT2G37560
    See related
    Araport:AT2G37560
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATORC2; F13M22.6; F13M22_6; origin recognition complex second largest subunit 2; ORIGIN RECOGNITION COMPLEX SECOND LARGEST SUBUNIT 2
    Summary
    Origin Recognition Complex subunit 2. Involved in the initiation of DNA replication. Regulated transcriptionally during cell cycle, peaking at G1/S-phase. Target of E2F/DF family of transcription factors. Interacts strongly with all ORC subunits.
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See ORC2 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    6
    Sequence:
    Chromosome: 2; NC_003071.7 (15758601..15761262)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene forkhead box protein G1 Neighboring gene NAD(P)-binding Rossmann-fold superfamily protein Neighboring gene ARF-GAP domain 7 Neighboring gene ncRNA Neighboring gene HSP20-like chaperones superfamily protein Neighboring gene RING/U-box superfamily protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Conserved initiator proteins in eukaryotes. Gavin KA, et al. Science, 1995 Dec 8. PMID 7502077
    2. The genes encoding Arabidopsis ORC subunits are E2F targets and the two ORC1 genes are differently expressed in proliferating and endoreplicating cells. Diaz-Trivino S, et al. Nucleic Acids Res, 2005. PMID 16179646, Free PMC Article
    3. Extensive signal integration by the phytohormone protein network. Altmann M, et al. Nature, 2020 Jul. PMID 32612234
    4. Evidence for network evolution in an Arabidopsis interactome map. Arabidopsis Interactome Mapping Consortium. Science, 2011 Jul 29. PMID 21798944, Free PMC Article
    5. Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana. Lin X, et al. Nature, 1999 Dec 16. PMID 10617197

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help
    NM_129311.3
    NM_201895.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA replication origin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA replication ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    part_of origin recognition complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    origin recognition complex second largest subunit 2
    NP_181292.1
    • origin recognition complex second largest subunit 2 (ORC2); CONTAINS InterPro DOMAIN/s: Origin recognition complex, subunit 2 (InterPro:IPR007220); Has 366 Blast hits to 364 proteins in 185 species: Archae - 0; Bacteria - 0; Metazoa - 129; Fungi - 134; Plants - 46; Viruses - 0; Other Eukaryotes - 57 (source: NCBI BLink).
    NP_973624.1
    • origin recognition complex second largest subunit 2 (ORC2); CONTAINS InterPro DOMAIN/s: Origin recognition complex, subunit 2 (InterPro:IPR007220); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      15758601..15761262
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_201895.3 → NP_973624.1  origin recognition complex second largest subunit 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_973624.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9X4Z5, F4IQY6
      Conserved Domains (1) summary
      pfam04084
      Location:33 → 332
      ORC2; Origin recognition complex subunit 2

    2. NM_129311.3 → NP_181292.1  origin recognition complex second largest subunit 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_181292.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q38899
      UniProtKB/TrEMBL
      A0A178VQV8, A0A5S9X4Z5
      Conserved Domains (1) summary
      pfam04084
      Location:33 → 353
      ORC2; Origin recognition complex subunit 2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q38899.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.