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    CDC6 cell division control 6 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 817518, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CDC6
    Official Full Name
    cell division control 6
    Primary source
    TAIR:AT2G29680
    Locus tag
    AT2G29680
    See related
    Araport:AT2G29680
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATCDC6; cell division control 6; T27A16.22; T27A16_22
    Summary
    Encodes cell division control protein 6 (CDC6).
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    Genomic context

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    See CDC6 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    16
    Sequence:
    Chromosome: 2; NC_003071.7 (12689171..12693121)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene zinc finger (C2H2 type) family protein Neighboring gene Tetratricopeptide repeat (TPR)-like superfamily protein Neighboring gene uncharacterized protein Neighboring gene anthranilate synthase 2 Neighboring gene pleckstrin homologue 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Expression and stability of Arabidopsis CDC6 are associated with endoreplication. Castellano MM, et al. Plant Cell, 2001 Dec. PMID 11752380, Free PMC Article
    2. DNA replication licensing affects cell proliferation or endoreplication in a cell type-specific manner. Castellano Mdel M, et al. Plant Cell, 2004 Sep. PMID 15316110, Free PMC Article
    3. Identification of kinase substrates by bimolecular complementation assays. Pusch S, et al. Plant J, 2012 Apr. PMID 22098373
    4. Targeted interactomics reveals a complex core cell cycle machinery in Arabidopsis thaliana. Van Leene J, et al. Mol Syst Biol, 2010 Aug 10. PMID 20706207, Free PMC Article
    5. Advanced proteomic analyses yield a deep catalog of ubiquitylation targets in Arabidopsis. Kim DY, et al. Plant Cell, 2013 May. PMID 23667124, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_128522.1
    NM_179806.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA endoreduplication TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in DNA replication initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    cell division control 6
    NP_565686.1
    • cell division control 6 (CDC6); INVOLVED IN: regulation of cell cycle, DNA replication; LOCATED IN: chloroplast; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: CDC6, C-terminal (InterPro:IPR015163), Cell division control, Cdc6 (InterPro:IPR016314); BEST Arabidopsis thaliana protein match is: Cell division control, Cdc6 (TAIR:AT1G07270.1); Has 1212 Blast hits to 1203 proteins in 331 species: Archae - 284; Bacteria - 0; Metazoa - 344; Fungi - 285; Plants - 98; Viruses - 0; Other Eukaryotes - 201 (source: NCBI BLink).
    NP_850137.1
    • cell division control 6 (CDC6); FUNCTIONS IN: ATP binding; INVOLVED IN: regulation of cell cycle, DNA replication; LOCATED IN: chloroplast; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: ATPase, AAA-type, core (InterPro:IPR003959), CDC6, C-terminal (InterPro:IPR015163), Cell division control, Cdc6 (InterPro:IPR016314); BEST Arabidopsis thaliana protein match is: Cell division control, Cdc6 (TAIR:AT1G07270.1); Has 1385 Blast hits to 1377 proteins in 339 species: Archae - 397; Bacteria - 0; Metazoa - 348; Fungi - 289; Plants - 116; Viruses - 0; Other Eukaryotes - 235 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      12689171..12693121
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_179806.2 → NP_850137.1  cell division control 6 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_850137.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9X2I3
      Conserved Domains (3) summary
      cd08768
      Location:411 → 493
      Cdc6_C; Winged-helix domain of essential DNA replication protein Cell division control protein (Cdc6), which mediates DNA binding
      COG1474
      Location:117 → 500
      CDC6; Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair]
      pfam13401
      Location:152 → 287
      AAA_22; AAA domain

    2. NM_128522.1 → NP_565686.1  cell division control 6 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_565686.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O82387, Q94CM2, Q94G54
      UniProtKB/TrEMBL
      A0A5S9X2I3
      Conserved Domains (3) summary
      cd08768
      Location:442 → 524
      Cdc6_C; Winged-helix domain of essential DNA replication protein Cell division control protein (Cdc6), which mediates DNA binding
      COG1474
      Location:117 → 531
      CDC6; Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair]
      pfam13401
      Location:152 → 281
      AAA_22; AAA domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O82387.2

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