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    RPA1A replication protein A 1A [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 815209, updated on 18-Sep-2024

    Summary

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    Official Symbol
    RPA1A
    Official Full Name
    replication protein A 1A
    Primary source
    TAIR:AT2G06510
    Locus tag
    AT2G06510
    See related
    Araport:AT2G06510
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS THALIANA REPLICATION PROTEIN A 1A; ARABIDOPSIS THALIANA RPA70-KDA SUBUNIT A; ATRPA1A; ATRPA70A; replication protein A 1A; RPA70-KDA SUBUNIT A; RPA70A; T12H3.6; T12H3_6
    Summary
    Encodes a homolog of Replication Protein A that is involved in meiosis I in pollen mother cells. rpa1a mutants have a reduced number of class I crossovers. The protein is located in chromatin-associated foci in early leptotene and can be detected in these foci until late pachytene of meiosis I.
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    Genomic context

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    See RPA1A in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    3
    Sequence:
    Chromosome: 2; NC_003071.7 (2584984..2587686)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene PttA/En/Spm family plant transposase Neighboring gene pseudo Neighboring gene hAT family dimerization domain-containing protein Neighboring gene photosystem II subunit X Neighboring gene SNF7 family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. HEI10 is subject to phase separation and mediates RPA1a degradation during meiotic interference-sensitive crossover formation. Wang T, et al. Proc Natl Acad Sci U S A, 2023 Dec 26. PMID 38134200, Free PMC Article
    2. Chromatin remodeling factor CHR18 interacts with replication protein RPA1A to regulate the DNA replication stress response in Arabidopsis. Han JJ, et al. New Phytol, 2018 Oct. PMID 29974976
    3. Arabidopsis replication protein A 70a is required for DNA damage response and telomere length homeostasis. Takashi Y, et al. Plant Cell Physiol, 2009 Nov. PMID 19812063
    4. Replication protein A (AtRPA1a) is required for class I crossover formation but is dispensable for meiotic DNA break repair. Osman K, et al. EMBO J, 2009 Feb 18. PMID 19153602, Free PMC Article
    5. Targeted interactomics reveals a complex core cell cycle machinery in Arabidopsis thaliana. Van Leene J, et al. Mol Syst Biol, 2010 Aug 10. PMID 20706207, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. HEI10 is subject to phase separation and mediates RPA1a degradation during meiotic interference-sensitive crossover formation.
      Title: HEI10 is subject to phase separation and mediates RPA1a degradation during meiotic interference-sensitive crossover formation.
    2. during DNA synthesis in plants, RPA1A interacts with CHR18 and recruits CHR18 to nuclear foci to resolve DNA replication stress.
      Title: Chromatin remodeling factor CHR18 interacts with replication protein RPA1A to regulate the DNA replication stress response in Arabidopsis.
    3. AtRPA70a plays an essential role in the DNA damage response as well as in telomere length regulation.
      Title: Arabidopsis replication protein A 70a is required for DNA damage response and telomere length homeostasis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_126648.4
    NM_201704.2

    Gene Ontology Provided by TAIR

    Process Evidence Code Pubs
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within chiasma assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within male gamete generation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within male meiosis I IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within pollen development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within reciprocal meiotic recombination IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    replication protein A 1A
    NP_178690.1
    • replication protein A 1A (RPA1A); FUNCTIONS IN: DNA binding, nucleic acid binding; INVOLVED IN: in 6 processes; LOCATED IN: nuclear chromatin; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Replication factor-a protein 1 Rpa1 (InterPro:IPR004591), Nucleic acid-binding, OB-fold-like (InterPro:IPR016027), Nucleic acid-binding, OB-fold (InterPro:IPR012340), Nucleic acid binding, OB-fold, tRNA/helicase-type (InterPro:IPR004365), Replication factor A, C-terminal (InterPro:IPR013955), Replication factor-A protein 1, N-terminal (InterPro:IPR007199); BEST Arabidopsis thaliana protein match is: Replication factor-A protein 1-related (TAIR:AT4G19130.1); Has 932 Blast hits to 912 proteins in 229 species: Archae - 16; Bacteria - 0; Metazoa - 191; Fungi - 147; Plants - 421; Viruses - 0; Other Eukaryotes - 157 (source: NCBI BLink).
    NP_973433.1
    • replication protein A 1A (RPA1A); FUNCTIONS IN: DNA binding, nucleic acid binding; INVOLVED IN: in 6 processes; LOCATED IN: nuclear chromatin; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Replication factor-a protein 1 Rpa1 (InterPro:IPR004591), Nucleic acid-binding, OB-fold-like (InterPro:IPR016027), Nucleic acid-binding, OB-fold (InterPro:IPR012340), Nucleic acid binding, OB-fold, tRNA/helicase-type (InterPro:IPR004365), Replication factor A, C-terminal (InterPro:IPR013955), Replication factor-A protein 1, N-terminal (InterPro:IPR007199); BEST Arabidopsis thaliana protein match is: Replication factor-A protein 1-related (TAIR:AT4G19130.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      2584984..2587686
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_126648.4 → NP_178690.1  replication protein A 1A [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_178690.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9SKI4
      UniProtKB/TrEMBL
      A0A178VXG3, A0A5S9WXI6, A0A654ETT6
      Conserved Domains (1) summary
      TIGR00617
      Location:3 → 638
      rpa1; replication factor-a protein 1 (rpa1)

    2. NM_201704.2 → NP_973433.1  replication protein A 1A [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_973433.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VXG3, F4IJA6
      Conserved Domains (5) summary
      cd04474
      Location:176 → 279
      RPA1_DBD_A; RPA1_DBD_A: A subfamily of OB folds corresponding to the second OB fold, the ssDNA-binding domain (DBD)-A, of human RPA1 (also called RPA70). RPA1 is the large subunit of Replication protein A (RPA). RPA is a nuclear ssDNA-binding protein (SSB) which ...
      TIGR00617
      Location:3 → 615
      rpa1; replication factor-a protein 1 (rpa1)
      pfam08646
      Location:460 → 611
      Rep_fac-A_C; Replication factor-A C terminal domain
      pfam16900
      Location:297 → 401
      REPA_OB_2; Replication protein A OB domain
      cl09930
      Location:3 → 80
      RPA_2b-aaRSs_OBF_like; Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SKI4.1

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