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    FH4 formin homologue 4 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 839028, updated on 18-Sep-2024

    Summary

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    Official Symbol
    FH4
    Official Full Name
    formin homologue 4
    Primary source
    TAIR:AT1G24150
    Locus tag
    AT1G24150
    See related
    Araport:AT1G24150
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATFH4; F3I6.8; F3I6_8; formin homologue 4; FORMIN HOMOLOGUE 4
    Summary
    Encodes a group I formin. Localized to cell junctions. Polymerizes actin. Binds profilin.
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    Genomic context

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    See FH4 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    2
    Sequence:
    Chromosome: 1; NC_003070.9 (8549191..8552086)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Interleukin-1 receptor-associated kinase 4 protein Neighboring gene triadin Neighboring gene Nucleotide-diphospho-sugar transferases superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An Immune-Responsive Cytoskeletal-Plasma Membrane Feedback Loop in Plants. Sassmann S, et al. Curr Biol, 2018 Jul 9. PMID 29937351, Free PMC Article
    2. The plant formin AtFH4 interacts with both actin and microtubules, and contains a newly identified microtubule-binding domain. Deeks MJ, et al. J Cell Sci, 2010 Apr 15. PMID 20332108
    3. Arabidopsis group Ie formins localize to specific cell membrane domains, interact with actin-binding proteins and cause defects in cell expansion upon aberrant expression. Deeks MJ, et al. New Phytol, 2005 Dec. PMID 16313636
    4. Formin homology 2 domains occur in multiple contexts in angiosperms. Cvrcková F, et al. BMC Genomics, 2004 Jul 15. PMID 15256004, Free PMC Article
    5. Formins: intermediates in signal-transduction cascades that affect cytoskeletal reorganization. Deeks MJ, et al. Trends Plant Sci, 2002 Nov. PMID 12417149

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001332639.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables actin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables actin filament binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within actin filament polymerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in actin nucleation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within defense response by cell wall thickening IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within defense response to fungus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in extracellular region ISM
    Inferred from Sequence Model
    more info
    		  
    colocalizes_with haustorium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    colocalizes_with plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasmodesma IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    formin homologue 4
    NP_001319073.1
    • formin homologue 4 (FH4); FUNCTIONS IN: actin binding, protein binding; INVOLVED IN: actin filament polymerization; LOCATED IN: cell-cell junction, plasma membrane; EXPRESSED IN: 19 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Actin-binding FH2/DRF autoregulatory (InterPro:IPR003104), Actin-binding FH2 (InterPro:IPR015425); BEST Arabidopsis thaliana protein match is: formin 8 (TAIR:AT1G70140.1); Has 28239 Blast hits to 15205 proteins in 945 species: Archae - 44; Bacteria - 3418; Metazoa - 10057; Fungi - 3019; Plants - 7022; Viruses - 1317; Other Eukaryotes - 3362 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      8549191..8552086
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001332640.1 → NP_001321805.1  formin homologue 4 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8AS15

    2. NM_001332639.1 → NP_001319073.1  formin homologue 4 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4I956, O48682
    Nucleotide Protein
    Heading Accession and Version

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