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    IAA12 AUX/IAA transcriptional regulator family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 839495, updated on 18-Sep-2024

    Summary

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    Official Symbol
    IAA12
    Official Full Name
    AUX/IAA transcriptional regulator family protein
    Primary source
    TAIR:AT1G04550
    Locus tag
    AT1G04550
    See related
    Araport:AT1G04550
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    BDL; BODENLOS; indole-3-acetic acid inducible 12; T1G11.20; T1G11_20
    Summary
    IAA12/BDL plays a role in auxin-mediated processes of apical-basal patterning in the embryo. bdl mutants lack a primary root meristem
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    Genomic context

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    See IAA12 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    5
    Sequence:
    Chromosome: 1; NC_003070.9 (1240294..1242157)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Tetratricopeptide repeat (TPR)-like superfamily protein Neighboring gene Calcium-dependent lipid-binding (CaLB domain) family protein Neighboring gene uncharacterized protein Neighboring gene AWPM-19-like family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The auxin-insensitive bodenlos mutation affects primary root formation and apical-basal patterning in the Arabidopsis embryo. Hamann T, et al. Development, 1999 Apr. PMID 10068632
    2. A novel, semi-dominant allele of MONOPTEROS provides insight into leaf initiation and vein pattern formation. Garrett JJ, et al. Planta, 2012 Jul. PMID 22349732
    3. The Arabidopsis BODENLOS gene encodes an auxin response protein inhibiting MONOPTEROS-mediated embryo patterning. Hamann T, et al. Genes Dev, 2002 Jul 1. PMID 12101120, Free PMC Article
    4. TOPLESS mediates auxin-dependent transcriptional repression during Arabidopsis embryogenesis. Szemenyei H, et al. Science, 2008 Mar 7. PMID 18258861
    5. Transcriptional repression of BODENLOS by HD-ZIP transcription factor HB5 in Arabidopsis thaliana. De Smet I, et al. J Exp Bot, 2013 Jul. PMID 23682118, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ARF4 regulates shoot regeneration through coordination with ARF5 and IAA12.
      Title: ARF4 regulates shoot regeneration through coordination with ARF5 and IAA12.
    2. HB5 negatively regulates BDL expression.
      Title: Transcriptional repression of BODENLOS by HD-ZIP transcription factor HB5 in Arabidopsis thaliana.
    3. TOPLESS (TPL) can interact with IAA12/BODENLOS through an ETHYLENE RESPONSE FACTOR-associated amphiphilic repression motif; study shows TPL is a transcriptional co-repressor & furthers understanding of how auxin regulates transcription during development
      Title: TOPLESS mediates auxin-dependent transcriptional repression during Arabidopsis embryogenesis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_100334.4
    NM_179258.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription cis-regulatory region binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within embryonic pattern specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to auxin IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within root development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within xylem and phloem pattern formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    AUX/IAA transcriptional regulator family protein
    NP_171949.1
    • indole-3-acetic acid inducible 12 (IAA12); FUNCTIONS IN: transcription repressor activity, sequence-specific DNA binding transcription factor activity; INVOLVED IN: xylem and phloem pattern formation, response to auxin stimulus, embryonic pattern specification, root development; LOCATED IN: nucleus; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Aux/IAA-ARF-dimerisation (InterPro:IPR011525), AUX/IAA protein (InterPro:IPR003311); BEST Arabidopsis thaliana protein match is: auxin-induced protein 13 (TAIR:AT2G33310.3); Has 2001 Blast hits to 2000 proteins in 81 species: Archae - 0; Bacteria - 0; Metazoa - 0; Fungi - 0; Plants - 2000; Viruses - 0; Other Eukaryotes - 1 (source: NCBI BLink).
    NP_849589.1
    • indole-3-acetic acid inducible 12 (IAA12); FUNCTIONS IN: transcription repressor activity, sequence-specific DNA binding transcription factor activity; INVOLVED IN: xylem and phloem pattern formation, response to auxin stimulus, embryonic pattern specification, root development; LOCATED IN: nucleus; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Aux/IAA-ARF-dimerisation (InterPro:IPR011525), AUX/IAA protein (InterPro:IPR003311); BEST Arabidopsis thaliana protein match is: auxin-induced protein 13 (TAIR:AT2G33310.3); Has 1087 Blast hits to 1087 proteins in 52 species: Archae - 0; Bacteria - 0; Metazoa - 0; Fungi - 0; Plants - 1087; Viruses - 0; Other Eukaryotes - 0 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      1240294..1242157
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_100334.4 → NP_171949.1  AUX/IAA transcriptional regulator family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_171949.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q38830, Q8LA42
      UniProtKB/TrEMBL
      A0A178WHL5
      Conserved Domains (1) summary
      pfam02309
      Location:47 → 226
      AUX_IAA; AUX/IAA family

    2. NM_179258.2 → NP_849589.1  AUX/IAA transcriptional regulator family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_849589.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1A7G0, F4I5P9
      Conserved Domains (1) summary
      pfam02309
      Location:68 → 163
      AUX_IAA; AUX/IAA family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q38830.1

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