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    SEC22 Synaptobrevin family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 837737, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SEC22
    Official Full Name
    Synaptobrevin family protein
    Primary source
    TAIR:AT1G11890
    Locus tag
    AT1G11890
    See related
    Araport:AT1G11890
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATSEC22; F12F1.27; F12F1_27; SECRETION 22
    Summary
    member of SEC22 Gene Family
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    Genomic context

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    See SEC22 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    6
    Sequence:
    Chromosome: 1; NC_003070.9 (4010757..4013104)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene miscRNA Neighboring gene transferases, transferring hexosyl groups Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Tetratricopeptide repeat (TPR)-like superfamily protein Neighboring gene ncRNA Neighboring gene B-cell receptor-associated protein 31-like protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis SNARE protein SEC22 is essential for gametophyte development and maintenance of Golgi-stack integrity. El-Kasmi F, et al. Plant J, 2011 Apr. PMID 21205036
    2. Sec22 and Memb11 are v-SNAREs of the anterograde endoplasmic reticulum-Golgi pathway in tobacco leaf epidermal cells. Chatre L, et al. Plant Physiol, 2005 Nov. PMID 16244155, Free PMC Article
    3. Caesium accumulation in yeast and plants is selectively repressed by loss of the SNARE Sec22p/SEC22. Dräxl S, et al. Nat Commun, 2013. PMID 23817436
    4. Endomembrane trafficking protein SEC24A regulates cell size patterning in Arabidopsis. Qu X, et al. Plant Physiol, 2014 Dec. PMID 25315606, Free PMC Article
    5. The transport signal on Sec22 for packaging into COPII-coated vesicles is a conformational epitope. Mancias JD, et al. Mol Cell, 2007 May 11. PMID 17499046

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The SNARE protein Sec22p/SEC22 specifically impacts Cesium(+) accumulation in yeast and in plants.
      Title: Caesium accumulation in yeast and plants is selectively repressed by loss of the SNARE Sec22p/SEC22.
    2. Loss of SEC22 function causes defects in gametophyte development. SEC22 is needed for the maintenance of Golgi-stack integrity.
      Title: Arabidopsis SNARE protein SEC22 is essential for gametophyte development and maintenance of Golgi-stack integrity.
    3. Our studies suggest that Sec22 and Memb11 are involved in anterograde protein trafficking at the ER-Golgi interface.
      Title: Sec22 and Memb11 are v-SNAREs of the anterograde endoplasmic reticulum-Golgi pathway in tobacco leaf epidermal cells.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_101060.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables SNAP receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Golgi organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within embryo sac development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endoplasmic reticulum organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within gametophyte development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within pollen development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region HDA PubMed 
    located_in plasma membrane HDA PubMed 

    General protein information

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    Preferred Names
    Synaptobrevin family protein
    NP_172653.1
    • SECRETION 22 (SEC22); FUNCTIONS IN: transporter activity; INVOLVED IN: transport, vesicle-mediated transport; LOCATED IN: Golgi apparatus, endoplasmic reticulum, plasma membrane, membrane; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Longin (InterPro:IPR010908), Longin-like (InterPro:IPR011012), Synaptobrevin (InterPro:IPR001388); BEST Arabidopsis thaliana protein match is: SNARE-like superfamily protein (TAIR:AT5G52270.1); Has 1577 Blast hits to 1577 proteins in 232 species: Archae - 0; Bacteria - 0; Metazoa - 548; Fungi - 342; Plants - 449; Viruses - 0; Other Eukaryotes - 238 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      4010757..4013104
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_101060.4 → NP_172653.1  Synaptobrevin family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_172653.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O65393, Q94AU2
      UniProtKB/TrEMBL
      A0A178WBU4, A0A5S9TWL2
      Conserved Domains (2) summary
      cd15866
      Location:133 → 196
      R-SNARE_SEC22; SNARE motif of SEC22
      cd14824
      Location:3 → 127
      Longin; longin domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q94AU2.1

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