AXR3 AUX/IAA transcriptional regulator family protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: AXR3
Official Full Name: AUX/IAA transcriptional regulator family protein
Primary source: TAIR:AT1G04250
Locus tag: AT1G04250
See related: Araport:AT1G04250
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: AtIAA17; AUXIN RESISTANT 3; F19P19.31; F19P19_31; IAA17; indole-3-acetic acid inducible 17
Summary: Transcription regulator acting as repressor of auxin-inducible gene expression. Auxin-inducible AUX/IAA gene. Short-lived nuclear protein with four conserved domains. Domain III has homology to beta alpha alpha dimerization and DNA binding domains. Involved in auxin signaling. Auxin induces the degradation of the protein in a dosage-dependent manner in a process mediated by AtRac1. Auxin induced the relocalization of the protein within the nucleus from a diffused nucleoplasmic pattern to a discrete particulated pattern named nuclear protein bodies or NPB in a process also mediated by Rac1. Colocalizes with SCF, CSN and 26S proteasome components.
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Genomic context

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See AXR3 in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 5

Sequence:: Chromosome: 1; NC_003070.9 (1136078..1138663)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Auxin co-receptor IAA17/AXR3 controls cell elongation in Arabidopsis thaliana root solely by modulation of nuclear auxin pathway.
Title: Auxin co-receptor IAA17/AXR3 controls cell elongation in Arabidopsis thaliana root solely by modulation of nuclear auxin pathway.
SUMO E3 ligase AtMMS21-dependent SUMOylation of AUXIN/INDOLE-3-ACETIC ACID 17 regulates auxin signaling.
Title: SUMO E3 ligase AtMMS21-dependent SUMOylation of AUXIN/INDOLE-3-ACETIC ACID 17 regulates auxin signaling.
Determinants of PB1 Domain Interactions in Auxin Response Factor ARF5 and Repressor IAA17.
Title: Determinants of PB1 Domain Interactions in Auxin Response Factor ARF5 and Repressor IAA17.
the identification of INDETERMINATE DOMAIN15 (IDD15) and INDOLE-3-ACETIC ACID 17 (IAA17) in Arabidopsis that interacted with ZAT6 in vivo provided new insight of ZAT6-mediated auxin signaling. Further investigation showed that ZAT6 repressed the transcription activation of IDD15 on the YUC2 promoter
Title: Zinc finger of Arabidopsis thaliana 6 is involved in melatonin-mediated auxin signaling through interacting INDETERMINATE DOMAIN15 and INDOLE-3-ACETIC ACID 17.
the results indicate that AtIAA17 is a positive modulator of natural leaf senescence and provides direct link between melatonin and AtIAA17 in the process of natural leaf senescence in Arabidopsis
Title: INDOLE-3-ACETIC ACID INDUCIBLE 17 positively modulates natural leaf senescence through melatonin-mediated pathway in Arabidopsis.
IAA17 and ARF5 associate to form homo- or hetero-oligomers using a common scaffold and binding interfaces, but their affinities vary significantly
Title: Structural basis for the auxin-induced transcriptional regulation by Aux/IAA17.
WOX5-IAA17 feedback circuit is essential for the maintenance of auxin gradient in the root tip.
Title: WOX5-IAA17 feedback circuit-mediated cellular auxin response is crucial for the patterning of root stem cell niches in Arabidopsis.
icu6 is a novel mutant allele of AXR3 that causes severe leaf incurvature, as well as enhanced responsiveness to auxin and growth defects in the adaxial domain of leaves.
Title: A role for AUXIN RESISTANT3 in the coordination of leaf growth.
AXR3/IAA17 might be involved in the brassinosteroid (BR) signaling pathway, suggesting an intersection node of BR-auxin signaling in root development
Title: Brassinosteroid signals control expression of the AXR3/IAA17 gene in the cross-talk point with auxin in root development.
PAX1 influences auxin response via its effects on AXR3 expression.
Title: pax1-1 partially suppresses gain-of-function mutations in Arabidopsis AXR3/IAA17.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_100306.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables DNA-binding transcription factor activity	NAS Non-traceable Author Statement more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within auxin-activated signaling pathway	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within positive regulation of leaf senescence	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to auxin	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to auxin	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to auxin	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: AUX/IAA transcriptional regulator family protein

NP_171921.1

AUXIN RESISTANT 3 (AXR3); CONTAINS InterPro DOMAIN/s: Aux/IAA-ARF-dimerisation (InterPro:IPR011525), AUX/IAA protein (InterPro:IPR003311); BEST Arabidopsis thaliana protein match is: indole-3-acetic acid inducible 14 (TAIR:AT4G14550.1); Has 1763 Blast hits to 1762 proteins in 78 species: Archae - 0; Bacteria - 0; Metazoa - 0; Fungi - 0; Plants - 1762; Viruses - 0; Other Eukaryotes - 1 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003070.9 Reference assembly

Range

1136078..1138663

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_100306.4 → NP_171921.1 AUX/IAA transcriptional regulator family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_171921.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O49162, P93830

UniProtKB/TrEMBL

A0A178WIK9, A0A5S9SIX8

Conserved Domains (1) summary

pfam02309
Location:11 → 220

AUX_IAA; AUX/IAA family