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    AXS1 UDP-D-apiose/UDP-D-xylose synthase 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 817332, updated on 18-Sep-2024

    Summary

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    Official Symbol
    AXS1
    Official Full Name
    UDP-D-apiose/UDP-D-xylose synthase 1
    Primary source
    TAIR:AT2G27860
    Locus tag
    AT2G27860
    See related
    Araport:AT2G27860
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F15K20.4; F15K20_4; UDP-D-apiose/UDP-D-xylose synthase 1
    Summary
    Encodes UDP-d-apiose/UDP-d-xylose synthase that requires NAD+ for enzymatic activity and is strongly inhibited by UDP-d-galacturonate.
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    Genomic context

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    See AXS1 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    9
    Sequence:
    Chromosome: 2; NC_003071.7 (11864277..11866998, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene histone deacetylase-related / HD-like protein Neighboring gene tRNA-Gly Neighboring gene pseudo Neighboring gene Argonaute family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The biosynthesis of the branched-chain sugar d-apiose in plants: functional cloning and characterization of a UDP-d-apiose/UDP-d-xylose synthase from Arabidopsis. Mølhøj M, et al. Plant J, 2003 Sep. PMID 12969423
    2. Arabidopsis thaliana AHL family modulates hypocotyl growth redundantly by interacting with each other via the PPC/DUF296 domain. Zhao J, et al. Proc Natl Acad Sci U S A, 2013 Nov 26. PMID 24218605, Free PMC Article
    3. Protein and metabolite composition of Arabidopsis stress granules. Kosmacz M, et al. New Phytol, 2019 May. PMID 30664249
    4. Profiling of the Receptor for Activated C Kinase 1a (RACK1a) interaction network in Arabidopsis thaliana. Guo J, et al. Biochem Biophys Res Commun, 2019 Dec 3. PMID 31606202
    5. Arabidopsis G-protein interactome reveals connections to cell wall carbohydrates and morphogenesis. Klopffleisch K, et al. Mol Syst Biol, 2011 Sep 27. PMID 21952135, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_128345.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables NAD binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables UDP-glucuronate decarboxylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within nucleotide-sugar biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytoplasm NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in cytoplasmic stress granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol HDA PubMed 
    located_in peroxisome HDA PubMed 

    General protein information

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    Preferred Names
    UDP-D-apiose/UDP-D-xylose synthase 1
    NP_180353.1
    • UDP-D-apiose/UDP-D-xylose synthase 1 (AXS1); FUNCTIONS IN: NAD or NADH binding, UDP-glucuronate decarboxylase activity; INVOLVED IN: nucleotide-sugar biosynthetic process; LOCATED IN: cytoplasm; EXPRESSED IN: 9 plant structures; EXPRESSED DURING: L mature pollen stage, M germinated pollen stage, seed development stages; CONTAINS InterPro DOMAIN/s: NAD-dependent epimerase/dehydratase (InterPro:IPR001509), NAD(P)-binding domain (InterPro:IPR016040); BEST Arabidopsis thaliana protein match is: UDP-D-apiose/UDP-D-xylose synthase 2 (TAIR:AT1G08200.1); Has 19662 Blast hits to 19651 proteins in 2697 species: Archae - 540; Bacteria - 12327; Metazoa - 255; Fungi - 84; Plants - 1208; Viruses - 17; Other Eukaryotes - 5231 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      11864277..11866998 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_128345.4 → NP_180353.1  UDP-D-apiose/UDP-D-xylose synthase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_180353.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9ZUY6
      UniProtKB/TrEMBL
      A0A178VYU0, A0A5S9X1U0
      Conserved Domains (1) summary
      PLN02427
      Location:4 → 389
      PLN02427; UDP-apiose/xylose synthase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ZUY6.1

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