SPA4 SPA1-related 4 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: SPA4
Official Full Name: SPA1-related 4
Primary source: TAIR:AT1G53090
Locus tag: AT1G53090
See related: Araport:AT1G53090
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: F8L10.5; F8L10_5; SPA1-related 4
Summary: Encodes a member of the SPA (suppressor of phyA-105) protein family (SPA1-SPA4). SPA proteins contain an N-terminal serine/threonine kinase-like motif followed by a coiled-coil structure and a C-terminal WD-repeat domain. SPA proteins function redundantly in suppressing photomorphogenesis in dark- and light-grown seedlings. SPA4 (and SPA3) predominantly regulates elongation growth in adult plants.
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Genomic context

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See SPA4 in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 8

Sequence:: Chromosome: 1; NC_003070.9 (19783185..19786902)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SPA proteins have a dual role: (1) they are required for light-responsiveness of COP1 subcellular localization, and (2) they promote COP1 activity in darkness in a fashion that is independent of the nuclear import/nuclear retention of COP1.
Title: SPA Proteins Affect the Subcellular Localization of COP1 in the COP1/SPA Ubiquitin Ligase Complex during Photomorphogenesis.
COP1/SPA activity, via LONG HYPOCOTYL IN FR LIGHT1, is required for shade-induced modulation of the auxin biosynthesis pathway and thereby enhances cell elongation in low red:far red.
Title: Arabidopsis COP1 and SPA genes are essential for plant elongation but not for acceleration of flowering time in response to a low red light to far-red light ratio.
SPA4 protein can self-associate or interact with each other, forming stable heterogeneous group of SPA-COP1 complexes regardless of light conditions but exhibit distinct expression profiles in different tissues and light conditions.
Title: Biochemical characterization of Arabidopsis complexes containing CONSTITUTIVELY PHOTOMORPHOGENIC1 and SUPPRESSOR OF PHYA proteins in light control of plant development.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_001333576.1

Supported by ESTs:

NM_001333577.1

Supported by ESTs:

NM_001333578.1

Supported by ESTs:

NM_104188.4

Supported by ESTs:

NM_179471.2

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in photomorphogenesis	IEA Inferred from Electronic Annotation more info
involved_in response to blue light	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of Cul4-RING E3 ubiquitin ligase complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in chloroplast	ISM Inferred from Sequence Model more info
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: SPA1-related 4

NP_175717.1

SPA1-related 4 (SPA4); FUNCTIONS IN: protein binding, signal transducer activity; INVOLVED IN: protein amino acid phosphorylation; LOCATED IN: CUL4 RING ubiquitin ligase complex, heterotrimeric G-protein complex; EXPRESSED IN: 19 plant structures; EXPRESSED DURING: 11 growth stages; CONTAINS InterPro DOMAIN/s: WD40 repeat 2 (InterPro:IPR019782), WD40 repeat, conserved site (InterPro:IPR019775), WD40 repeat (InterPro:IPR001680), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), G-protein beta WD-40 repeat, region (InterPro:IPR020472), WD40 repeat-like-containing domain (InterPro:IPR011046), Protein kinase, catalytic domain (InterPro:IPR000719), WD40-repeat-containing domain (InterPro:IPR017986), WD40/YVTN repeat-like-containing domain (InterPro:IPR015943), WD40 repeat, subgroup (InterPro:IPR019781); BEST Arabidopsis thaliana protein match is: SPA1-related 3 (TAIR:AT3G15354.1); Has 39467 Blast hits to 23259 proteins in 713 species: Archae - 38; Bacteria - 5854; Metazoa - 15099; Fungi - 8579; Plants - 4750; Viruses - 0; Other Eukaryotes - 5147 (source: NCBI BLink).

NP_849802.1

SPA1-related 4 (SPA4); FUNCTIONS IN: protein binding, signal transducer activity; INVOLVED IN: protein amino acid phosphorylation; LOCATED IN: CUL4 RING ubiquitin ligase complex, heterotrimeric G-protein complex; EXPRESSED IN: 19 plant structures; EXPRESSED DURING: 11 growth stages; CONTAINS InterPro DOMAIN/s: WD40 repeat 2 (InterPro:IPR019782), WD40 repeat, conserved site (InterPro:IPR019775), WD40 repeat (InterPro:IPR001680), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), G-protein beta WD-40 repeat, region (InterPro:IPR020472), WD40 repeat-like-containing domain (InterPro:IPR011046), Protein kinase, catalytic domain (InterPro:IPR000719), WD40-repeat-containing domain (InterPro:IPR017986), WD40/YVTN repeat-like-containing domain (InterPro:IPR015943), WD40 repeat, subgroup (InterPro:IPR019781); BEST Arabidopsis thaliana protein match is: SPA1-related 3 (TAIR:AT3G15354.1); Has 39467 Blast hits to 23259 proteins in 713 species: Archae - 38; Bacteria - 5854; Metazoa - 15099; Fungi - 8579; Plants - 4750; Viruses - 0; Other Eukaryotes - 5147 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003070.9 Reference assembly

Range

19783185..19786902

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_104188.4 → NP_175717.1 SPA1-related 4 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_175717.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q94BM7, Q9LNN4

UniProtKB/TrEMBL

A0A178WBA0, A0A5S9WPG8

Conserved Domains (2) summary

PLN00181
Location:1 → 794

PLN00181; protein SPA1-RELATED; Provisional

sd00039
Location:487 → 529

7WD40; WD40 repeat [structural motif]
NM_001333576.1 → NP_001321533.1 SPA1-related 4 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q94BM7, Q9LNN4

UniProtKB/TrEMBL

A0A178WBA0, A0A5S9WPG8

Conserved Domains (2) summary

PLN00181
Location:1 → 794

PLN00181; protein SPA1-RELATED; Provisional

sd00039
Location:487 → 529

7WD40; WD40 repeat [structural motif]
NM_179471.2 → NP_849802.1 SPA1-related 4 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_849802.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q94BM7, Q9LNN4

UniProtKB/TrEMBL

A0A178WBA0, A0A5S9WPG8

Conserved Domains (2) summary

PLN00181
Location:1 → 794

PLN00181; protein SPA1-RELATED; Provisional

sd00039
Location:487 → 529

7WD40; WD40 repeat [structural motif]
NM_001333577.1 → NP_001321532.1 SPA1-related 4 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1P8AR67

Conserved Domains (2) summary

PLN00181
Location:1 → 573

PLN00181; protein SPA1-RELATED; Provisional

sd00039
Location:266 → 308

7WD40; WD40 repeat [structural motif]
NM_001333578.1 → NP_001321534.1 SPA1-related 4 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1P8ARD3