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    BAC2 Mitochondrial substrate carrier family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 844329, updated on 18-Sep-2024

    Summary

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    Official Symbol
    BAC2
    Official Full Name
    Mitochondrial substrate carrier family protein
    Primary source
    TAIR:AT1G79900
    Locus tag
    AT1G79900
    See related
    Araport:AT1G79900
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS MITOCHONDRIAL BASIC AMINO ACID CARRIER 2; ATMBAC2; F19K16.14; F19K16_14; RABIDOPSIS MITOCHONDRIAL BASIC AMINO ACID CARRIER 2
    Summary
    encodes a mitochondrial ornithine transporter that exports ornithine from the mitochondria to the cytosol
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    Genomic context

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    See BAC2 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    2
    Sequence:
    Chromosome: 1; NC_003070.9 (30051955..30053936, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene RHO guanyl-nucleotide exchange factor 12 Neighboring gene D-isomer specific 2-hydroxyacid dehydrogenase family protein Neighboring gene RNA recognition motif (RRM)-containing protein Neighboring gene RAD3-like DNA-binding helicase protein Neighboring gene Regulator of Vps4 activity in the MVB pathway protein Neighboring gene Putative methyltransferase family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mutations in the hyperosmotic stress-responsive mitochondrial BASIC AMINO ACID CARRIER2 enhance proline accumulation in Arabidopsis. Toka I, et al. Plant Physiol, 2010 Apr. PMID 20172963, Free PMC Article
    2. Arabidopsis mitochondria have two basic amino acid transporters with partially overlapping specificities and differential expression in seedling development. Palmieri L, et al. Biochim Biophys Acta, 2006 Sep-Oct. PMID 16730327
    3. Expression pattern of a nuclear encoded mitochondrial arginine-ornithine translocator gene from Arabidopsis. Catoni E, et al. BMC Plant Biol, 2003 Jan 7. PMID 12517306, Free PMC Article
    4. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. data suggest that BAC2 is a hyperosmotic stress-inducible transporter of basic amino acids that contributes to proline accumulation in response to hyperosmotic stress in Arabidopsis
      Title: Mutations in the hyperosmotic stress-responsive mitochondrial BASIC AMINO ACID CARRIER2 enhance proline accumulation in Arabidopsis.
    2. BAC1 and BAC2 displayed highest affinity for arginine with similar Km and Vmax. However, BAC2 transported citrulline for which BAC1 had little or no affinity. Furthermore, BAC2 was less stereospecific than BAC1.[BAC2]
      Title: Arabidopsis mitochondria have two basic amino acid transporters with partially overlapping specificities and differential expression in seedling development.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    NM_106639.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables L-arginine transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables L-histidine transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables L-lysine transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables L-ornithine transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables L-ornithine transmembrane transporter activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables carnitine:acyl carnitine antiporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within hyperosmotic response IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within proline biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    Mitochondrial substrate carrier family protein
    NP_178108.1
    • BAC2; CONTAINS InterPro DOMAIN/s: Mitochondrial carrier protein (InterPro:IPR002067), Mitochondrial substrate carrier (InterPro:IPR001993), Mitochondrial substrate/solute carrier (InterPro:IPR018108); BEST Arabidopsis thaliana protein match is: Mitochondrial substrate carrier family protein (TAIR:AT5G46800.1); Has 25782 Blast hits to 14100 proteins in 457 species: Archae - 0; Bacteria - 6; Metazoa - 10775; Fungi - 7497; Plants - 4679; Viruses - 6; Other Eukaryotes - 2819 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      30051955..30053936 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_106639.5 → NP_178108.1  Mitochondrial substrate carrier family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_178108.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D5LRV2, D5LRV3, Q8LB35, Q9CA93
      UniProtKB/TrEMBL
      A0A178W6T8, A0A5S9WVW3, A0A654EQI2
      Conserved Domains (1) summary
      pfam00153
      Location:204 → 285
      Mito_carr; Mitochondrial carrier protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CA93.1

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