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    Leucine-rich receptor-like protein kinase family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 843550, updated on 18-Sep-2024

    Summary

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    Official Full Name
    Leucine-rich receptor-like protein kinase family protein
    Primary source
    TAIR:AT1G72180
    Locus tag
    AT1G72180
    See related
    Araport:AT1G72180
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    C-terminally encoded peptide receptor 2; CEPR2; T9N14.3; T9N14_3
    Summary
    Encodes a leucine-rich repeat receptor kinase that functions as a receptor for CEP1 peptide. Mediates nitrate uptake signaling.
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    Genomic context

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    Location:
    chromosome: 1
    Exon count:
    4
    Sequence:
    Chromosome: 1; NC_003070.9 (27162820..27167430)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene MICOS complex subunit, putative (DUF543) Neighboring gene E3 ubiquitin-protein ligase RNF170-like protein (DUF 1232) Neighboring gene D-isomer specific 2-hydroxyacid dehydrogenase family protein Neighboring gene RING/U-box superfamily protein Neighboring gene basic helix-loop-helix (bHLH) DNA-binding superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Regulation of the stability and ABA import activity of NRT1.2/NPF4.6 by CEPR2-mediated phosphorylation in Arabidopsis. Zhang L, et al. Mol Plant, 2021 Apr 5. PMID 33453414
    2. Probing the roles of LRR RLK genes in Arabidopsis thaliana roots using a custom T-DNA insertion set. ten Hove CA, et al. Plant Mol Biol, 2011 May. PMID 21431781, Free PMC Article
    3. CEPR2 phosphorylates and accelerates the degradation of PYR/PYLs in Arabidopsis. Yu Z, et al. J Exp Bot, 2019 Oct 15. PMID 31232446, Free PMC Article
    4. Perception of root-derived peptides by shoot LRR-RKs mediates systemic N-demand signaling. Tabata R, et al. Science, 2014 Oct 17. PMID 25324386
    5. A membrane protein/signaling protein interaction network for Arabidopsis version AMPv2. Lalonde S, et al. Front Physiol, 2010. PMID 21423366, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Regulation of the stability and ABA import activity of NRT1.2/NPF4.6 by CEPR2-mediated phosphorylation in Arabidopsis.
      Title: Regulation of the stability and ABA import activity of NRT1.2/NPF4.6 by CEPR2-mediated phosphorylation in Arabidopsis.
    2. Loss of function by T-DNA insertion in C-terminally encoded peptide receptor 2 (CEPR2) together with phloem intercalated with xylem (PXY) and PXY-Like 2 (PXL2) led to abscisic acid (ABA) hypersensitivity, while CEPR2 overexpression led to ABA insensitivity compared with the wild type, indicating the redundant and negative roles of CEPR2, PXY, and PXL2 in ABA signaling.
      Title: CEPR2 phosphorylates and accelerates the degradation of PYR/PYLs in Arabidopsis.
    3. this study concluded that two LRR-RKs At5g49660 and At1g72180 function as CEP receptors and named them CEPR1 and CEPR2.
      Title: Perception of root-derived peptides by shoot LRR-RKs mediates systemic N-demand signaling.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_105877.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables peptide binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables peptide binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables peptide hormone binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables peptide receptor activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transmembrane receptor protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within nitrate import IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in nitrate import IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of root development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of shoot system development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in response to mannitol IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to nitrate starvation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in response to osmotic stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    Leucine-rich receptor-like protein kinase family protein
    NP_177363.1
    • Leucine-rich receptor-like protein kinase family protein; FUNCTIONS IN: protein serine/threonine kinase activity, kinase activity, ATP binding; INVOLVED IN: transmembrane receptor protein tyrosine kinase signaling pathway, protein amino acid phosphorylation; LOCATED IN: cellular_component unknown; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Protein kinase, catalytic domain (InterPro:IPR000719), Leucine-rich repeat-containing N-terminal domain, type 2 (InterPro:IPR013210), Leucine-rich repeat (InterPro:IPR001611), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: HAESA-like 1 (TAIR:AT1G28440.1); Has 222922 Blast hits to 143384 proteins in 4612 species: Archae - 143; Bacteria - 22250; Metazoa - 69718; Fungi - 11673; Plants - 90830; Viruses - 408; Other Eukaryotes - 27900 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      27162820..27167430
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_105877.3 → NP_177363.1  Leucine-rich receptor-like protein kinase family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_177363.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0WPH6, Q9C7T7
      UniProtKB/TrEMBL
      A0A178WLL8
      Conserved Domains (2) summary
      sd00033
      Location:100 → 123
      LRR_RI; leucine-rich repeat [structural motif]
      cl26793
      Location:19 → 961
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9C7T7.1

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