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    TOC64-III translocon at the outer membrane of chloroplasts 64-III [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 819660, updated on 18-Sep-2024

    Summary

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    Official Symbol
    TOC64-III
    Official Full Name
    translocon at the outer membrane of chloroplasts 64-III
    Primary source
    TAIR:AT3G17970
    Locus tag
    AT3G17970
    See related
    Araport:AT3G17970
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AT3G17960; atToc64-III; translocon at the outer membrane of chloroplasts 64-III
    Summary
    Integral chloroplast outer membrane protein. Belongs to one of the 36 carboxylate clamp (CC)-tetratricopeptide repeat (TPR) proteins (Prasad 2010, Pubmed ID: 20856808) with potential to interact with Hsp90/Hsp70 as co-chaperones.
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    Genomic context

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    See TOC64-III in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    13
    Sequence:
    Chromosome: 3; NC_003074.8 (6147906..6152082)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene Galactose mutarotase-like superfamily protein Neighboring gene uncharacterized protein Neighboring gene Calcium-dependent lipid-binding (CaLB domain) family protein Neighboring gene S-adenosyl-L-methionine-dependent methyltransferases superfamily protein Neighboring gene WUSCHEL related homeobox 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ligand recognition by the TPR domain of the import factor Toc64 from Arabidopsis thaliana. Panigrahi R, et al. PLoS One, 2013. PMID 24391770, Free PMC Article
    2. Evolutionarily evolved discriminators in the 3-TPR domain of the Toc64 family involved in protein translocation at the outer membrane of chloroplasts and mitochondria. Mirus O, et al. J Mol Model, 2009 Aug. PMID 19198901
    3. Toc64--a preprotein-receptor at the outer membrane with bipartide function. Qbadou S, et al. J Mol Biol, 2007 Apr 13. PMID 17306301
    4. Exploring ligand recognition, selectivity and dynamics of TPR domains of chloroplast Toc64 and mitochondria Om64 from Arabidopsis thaliana. Panigrahi R, et al. J Mol Recognit, 2014 Jun. PMID 24700626
    5. Toc33 and Toc64-III cooperate in precursor protein import into the chloroplasts of Arabidopsis thaliana. Sommer M, et al. Plant Cell Environ, 2013 May. PMID 23131143

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Our findings suggest that the TPR domain from AtToc64 has higher affinity towards C-terminal residues of Hsp70.
      Title: Exploring ligand recognition, selectivity and dynamics of TPR domains of chloroplast Toc64 and mitochondria Om64 from Arabidopsis thaliana.
    2. mode of recognition of the C-termini of Hsp70 and Hsp90 chaperones by the Tetratricopeptide Repeat (TPR) domain of the chloroplast import receptor Toc64
      Title: Ligand recognition by the TPR domain of the import factor Toc64 from Arabidopsis thaliana.
    3. Toc64 participates in chloroplast protein import and cooperates in part with Toc33.
      Title: Toc33 and Toc64-III cooperate in precursor protein import into the chloroplasts of Arabidopsis thaliana.
    4. Data built homology models of the 3-TPR domain of chloroplastic Toc64 from different species.
      Title: Evolutionarily evolved discriminators in the 3-TPR domain of the Toc64 family involved in protein translocation at the outer membrane of chloroplasts and mitochondria.
    5. Toc64 is involved in preprotein translocation across the outer envelope at both sites of the membrane.
      Title: Toc64--a preprotein-receptor at the outer membrane with bipartide function.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001338317.1
    NM_112678.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast envelope HDA PubMed 
    located_in chloroplast outer membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol HDA PubMed 
    located_in plastid HDA PubMed 

    General protein information

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    Preferred Names
    translocon at the outer membrane of chloroplasts 64-III
    NP_188424.2
    • translocon at the outer membrane of chloroplasts 64-III (TOC64-III); FUNCTIONS IN: binding, carbon-nitrogen ligase activity, with glutamine as amido-N-donor; LOCATED IN: integral to chloroplast outer membrane, chloroplast; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Tetratricopeptide TPR-1 (InterPro:IPR001440), Tetratricopeptide-like helical (InterPro:IPR011990), Amidase (InterPro:IPR000120), Tetratricopeptide repeat-containing (InterPro:IPR013026), Tetratricopeptide repeat (InterPro:IPR019734); BEST Arabidopsis thaliana protein match is: translocon at the outer membrane of chloroplasts 64-V (TAIR:AT5G09420.1); Has 32911 Blast hits to 27744 proteins in 2680 species: Archae - 530; Bacteria - 15888; Metazoa - 4120; Fungi - 2515; Plants - 2100; Viruses - 0; Other Eukaryotes - 7758 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      6147906..6152082
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_112678.4 → NP_188424.2  translocon at the outer membrane of chloroplasts 64-III [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_188424.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9LVH5
      UniProtKB/TrEMBL
      A0A178V5L5, A0A5S9XD70
      Conserved Domains (3) summary
      TIGR00990
      Location:463 → 588
      3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
      sd00006
      Location:474 → 502
      TPR; TPR repeat [structural motif]
      cl18951
      Location:33 → 451
      Amidase

    2. NM_001338317.1 → NP_001325422.1  translocon at the outer membrane of chloroplasts 64-III [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178V5L5, A0A1I9LL70
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LVH5.1

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