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    DNA-3-methyladenine glycosylase (MAG) [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 820378, updated on 18-Sep-2024

    Summary

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    Official Full Name
    DNA-3-methyladenine glycosylase (MAG)
    Primary source
    TAIR:AT3G12040
    Locus tag
    AT3G12040
    See related
    Araport:AT3G12040
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    MEC18.4
    Summary
    Encodes a 3-methyladenine-DNA glycosylase. Arabdiopsis cDNA complements the methyl methanesulfonate-sensitive phenotype of an Escherichia coli double mutant deficient in 3-methyladenine glycosylases (DNA-3-methyladenine glycosidases I and II, EC 3.2.2.20 and 3.2.2.21, respectively, encoded by tag and alkA).
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    Genomic context

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    Location:
    chromosome: 3
    Exon count:
    6
    Sequence:
    Chromosome: 3; NC_003074.8 (3835129..3836849, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene C18orf8 Neighboring gene P-loop containing nucleoside triphosphate hydrolases superfamily protein Neighboring gene transmembrane/coiled-coil protein (Protein of unknown function DUF106, transmembrane) Neighboring gene Aha1 domain-containing protein Neighboring gene trichome birefringence-like protein (DUF828) Neighboring gene RAB geranylgeranyl transferase beta subunit 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cloning of a 3-methyladenine-DNA glycosylase from Arabidopsis thaliana. Santerre A, et al. Proc Natl Acad Sci U S A, 1994 Mar 15. PMID 8134381, Free PMC Article
    2. Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana. Salanoubat M, et al. Nature, 2000 Dec 14. PMID 11130713

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    NM_001337971.1
    NM_112038.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-3-methyladenine glycosylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-3-methyladenine glycosylase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables DNA-3-methylguanine glycosylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-7-methyladenine glycosylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-7-methylguanine glycosylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in base-excision repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    DNA-3-methyladenine glycosylase (MAG)
    NP_187811.1
    • DNA-3-methyladenine glycosylase (MAG); FUNCTIONS IN: DNA binding, alkylbase DNA N-glycosylase activity, catalytic activity; INVOLVED IN: base-excision repair; LOCATED IN: cellular_component unknown; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Methylpurine-DNA glycosylase (MPG) (InterPro:IPR003180), Formyl transferase, C-terminal-like (InterPro:IPR011034); Has 2384 Blast hits to 2384 proteins in 1044 species: Archae - 26; Bacteria - 1995; Metazoa - 85; Fungi - 6; Plants - 30; Viruses - 0; Other Eukaryotes - 242 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      3835129..3836849 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_112038.3 → NP_187811.1  DNA-3-methyladenine glycosylase (MAG) [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_187811.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q39147
      UniProtKB/TrEMBL
      A0A178VCT9, A0A5S9XBJ8, Q0WSZ1
      Conserved Domains (1) summary
      TIGR00567
      Location:59 → 245
      3mg; DNA-3-methyladenine glycosylase

    2. NM_001337971.1 → NP_001326241.1  DNA-3-methyladenine glycosylase (MAG) [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1I9LNN7
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q39147.1

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