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    ADR1 Disease resistance protein (CC-NBS-LRR class) family [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 840250, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ADR1
    Official Full Name
    Disease resistance protein (CC-NBS-LRR class) family
    Primary source
    TAIR:AT1G33560
    Locus tag
    AT1G33560
    See related
    Araport:AT1G33560
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ACTIVATED DISEASE RESISTANCE 1; F10C21.19
    Summary
    Encodes a NBS-LRR disease resistance protein that possesses N-terminal kinase subdomains. Activation tagged mutant of ADR1 showed elevated levels of SA and reactive oxygen species in addition to number of defense gene transcripts. Exhibits resistance to number of microbial pathogens.
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    Genomic context

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    See ADR1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    5
    Sequence:
    Chromosome: 1; NC_003070.9 (12168768..12172119)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene serine carboxypeptidase-like 18 Neighboring gene pseudo Neighboring gene pseudo Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis ADR1 helper NLR immune receptors localize and function at the plasma membrane in a phospholipid dependent manner. Saile SC, et al. New Phytol, 2021 Dec. PMID 34628646
    2. Genetic requirements for signaling from an autoactive plant NB-LRR intracellular innate immune receptor. Roberts M, et al. PLoS Genet, 2013. PMID 23633962, Free PMC Article
    3. Drought tolerance established by enhanced expression of the CC-NBS-LRR gene, ADR1, requires salicylic acid, EDS1 and ABI1. Chini A, et al. Plant J, 2004 Jun. PMID 15144382
    4. Targeted activation tagging of the Arabidopsis NBS-LRR gene, ADR1, conveys resistance to virulent pathogens. Grant JJ, et al. Mol Plant Microbe Interact, 2003 Aug. PMID 12906111
    5. The truncated TNL receptor TN2-mediated immune responses require ADR1 function. Wang W, et al. Plant J, 2021 Nov. PMID 34396631

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The EDS1-PAD4-ADR1 node mediates Arabidopsis pattern-triggered immunity.
      Title: The EDS1-PAD4-ADR1 node mediates Arabidopsis pattern-triggered immunity.
    2. The truncated TNL receptor TN2-mediated immune responses require ADR1 function.
      Title: The truncated TNL receptor TN2-mediated immune responses require ADR1 function.
    3. Arabidopsis ADR1 helper NLR immune receptors localize and function at the plasma membrane in a phospholipid dependent manner.
      Title: Arabidopsis ADR1 helper NLR immune receptors localize and function at the plasma membrane in a phospholipid dependent manner.
    4. Loss of the common immune coreceptor BAK1 leads to NLR-dependent cell death.
      Title: Loss of the common immune coreceptor BAK1 leads to NLR-dependent cell death.
    5. These data allows us to propose a genetic model that provides insight into an SA-dependent feedback regulation loop, which, surprisingly, includes ADR1-L2
      Title: Genetic requirements for signaling from an autoactive plant NB-LRR intracellular innate immune receptor.
    Submit: New GeneRIF Correction

    General gene information

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    NM_103079.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ADP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within defense response to bacterium IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in defense response to fungus IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to other organism IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to water deprivation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    Disease resistance protein (CC-NBS-LRR class) family
    NP_174620.2
    • ACTIVATED DISEASE RESISTANCE 1 (ADR1); FUNCTIONS IN: kinase activity; INVOLVED IN: response to water deprivation, response to karrikin, response to other organism, defense response; LOCATED IN: endomembrane system; EXPRESSED IN: 21 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: NB-ARC (InterPro:IPR002182), Powdery mildew resistance protein, RPW8 domain (InterPro:IPR008808), Disease resistance protein (InterPro:IPR000767); BEST Arabidopsis thaliana protein match is: ADR1-like 2 (TAIR:AT5G04720.1); Has 17381 Blast hits to 12089 proteins in 491 species: Archae - 20; Bacteria - 813; Metazoa - 875; Fungi - 81; Plants - 15224; Viruses - 0; Other Eukaryotes - 368 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      12168768..12172119
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_103079.4 → NP_174620.2  Disease resistance protein (CC-NBS-LRR class) family [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_174620.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9FW44
      UniProtKB/TrEMBL
      Q0WQR8
      Conserved Domains (3) summary
      sd00033
      Location:602 → 632
      LRR_RI; leucine-rich repeat [structural motif]
      pfam00931
      Location:173 → 414
      NB-ARC; NB-ARC domain
      pfam05659
      Location:10 → 117
      RPW8; Arabidopsis broad-spectrum mildew resistance protein RPW8
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FW44.2

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