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    ETFALPHA electron transfer flavoprotein alpha [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 841516, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ETFALPHA
    Official Full Name
    electron transfer flavoprotein alpha
    Primary source
    TAIR:AT1G50940
    Locus tag
    AT1G50940
    See related
    Araport:AT1G50940
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    electron transfer flavoprotein alpha; F8A12.16; F8A12_16
    Summary
    Encodes the electron transfer flavoprotein ETF alpha, a putative subunit of the mitochondrial electron transfer flavoprotein complex (ETF beta is At5g43430.1) in Arabidopsis. Mutations of the ETF beta gene results in accelerated senescence and early death compared to wild-type during extended darkness.
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    Genomic context

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    See ETFALPHA in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    8
    Sequence:
    Chromosome: 1; NC_003070.9 (18877812..18880012, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene Nucleolar GTP-binding protein Neighboring gene Serine/Threonine-kinase Neighboring gene ncRNA Neighboring gene protein disulfide-isomerase 5-like protein (DUF1692) Neighboring gene ncRNA Neighboring gene gibberellin 2-oxidase 7

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The mitochondrial electron transfer flavoprotein complex is essential for survival of Arabidopsis in extended darkness. Ishizaki K, et al. Plant J, 2006 Sep. PMID 16923016
    2. Lipoic acid-dependent oxidative catabolism of alpha-keto acids in mitochondria provides evidence for branched-chain amino acid catabolism in Arabidopsis. Taylor NL, et al. Plant Physiol, 2004 Feb. PMID 14764908, Free PMC Article
    3. Divalent metal ions in plant mitochondria and their role in interactions with proteins and oxidative stress-induced damage to respiratory function. Tan YF, et al. Plant Physiol, 2010 Feb. PMID 20018591, Free PMC Article
    4. Experimental analysis of the Arabidopsis mitochondrial proteome highlights signaling and regulatory components, provides assessment of targeting prediction programs, and indicates plant-specific mitochondrial proteins. Heazlewood JL, et al. Plant Cell, 2004 Jan. PMID 14671022, Free PMC Article
    5. A Pan-plant Protein Complex Map Reveals Deep Conservation and Novel Assemblies. McWhite CD, et al. Cell, 2020 Apr 16. PMID 32191846, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_103974.6

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables copper ion binding HDA PubMed 
    enables electron transfer activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    electron transfer flavoprotein alpha
    NP_175507.1
    • electron transfer flavoprotein alpha (ETFALPHA); FUNCTIONS IN: copper ion binding; LOCATED IN: mitochondrion; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Electron transfer flavoprotein, alpha subunit, C-terminal (InterPro:IPR014731), Rossmann-like alpha/beta/alpha sandwich fold (InterPro:IPR014729), Electron transfer flavoprotein, alpha/beta-subunit, N-terminal (InterPro:IPR014730), Electron transfer flavoprotein, alpha subunit (InterPro:IPR001308), Electron transfer flavoprotein, alpha subunit, C-terminal, conserved site (InterPro:IPR018206); Has 7540 Blast hits to 7533 proteins in 1658 species: Archae - 158; Bacteria - 4517; Metazoa - 162; Fungi - 143; Plants - 45; Viruses - 0; Other Eukaryotes - 2515 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      18877812..18880012 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_103974.6 → NP_175507.1  electron transfer flavoprotein alpha [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_175507.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9C6I6
      UniProtKB/TrEMBL
      A0A178WJP1, A0A5S9WL74
      Conserved Domains (1) summary
      PLN00022
      Location:11 → 363
      PLN00022; electron transfer flavoprotein subunit alpha; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9C6I6.1

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